Disturbances in Cholesterol Homeostasis and Non-alcoholic Fatty Liver Diseases

Volixibat in adults with non-alcoholic steatohepatitis: 24-week interim analysis from a randomized, phase II study

(2020) Philip N. Newsome et al.   JOURNAL OF HEPATOLOGY

The utility of ezetimibe therapy in nonalcoholic fatty liver disease

(2019) Baek Gyu Jun et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice

(2019) Kanita Salic et al.   PLoS One

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Statins: An Under-Appreciated Asset for the Prevention and the Treatment of NAFLD or NASH and the Related Cardiovascular Risk

(2018) Vasilios G. Athyros et al.   Current Vascular Pharmacology

Hypoxic Signaling and Cholesterol Lipotoxicity in Fatty Liver Disease Progression

(2018) Oren Tirosh   Oxidative Medicine and Cellular Longevity

Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis

(2018) Hyo Young Lee et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Statins: Old drugs as new therapy for liver diseases?

(2018) Elisa Pose et al.   JOURNAL OF HEPATOLOGY

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

(2017) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Statins improve NASH via inhibition of RhoA and Ras

(2016) Robert Schierwagen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cardiovascular Disease and Myocardial Abnormalities in Nonalcoholic Fatty Liver Disease

(2016) Alessandro Mantovani et al.   DIGESTIVE DISEASES AND SCIENCES

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

(2016) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

(2016) Anuradha Rao et al.   Science Translational Medicine

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells

(2015) Lee-Won Chong et al.   BMC GASTROENTEROLOGY

Achievement of Dual Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Targets More Frequent With the Addition of Ezetimibe to Simvastatin and Associated With Better Outcomes in IMPROVE-ITCLINICAL PERSPECTIVES

(2015) Erin A. Bohula et al.   CIRCULATION

Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)

(2015) Rohit Loomba et al.   HEPATOLOGY

Statin use and non-alcoholic steatohepatitis in at risk individuals

(2015) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

Proof That Lower Is Better — LDL Cholesterol and IMPROVE-IT

(2015) John A. Jarcho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine

(2015) Jianglin Fan et al.   PHARMACOLOGY & THERAPEUTICS

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

(2015) Robert Schierwagen et al.   Scientific Reports

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

(2014) Yumie Takeshita et al.   DIABETOLOGIA

The functional role of microRNAs in alcoholic liver injury

(2014) Kelly McDaniel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells

(2014) Kengo Tomita et al.   JOURNAL OF HEPATOLOGY

Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation

(2014) Eung Ju Kim et al.   PLoS One

Simvastatin maintains function and viability of steatotic rat livers procured for transplantation

(2013) Jordi Gracia-Sancho et al.   JOURNAL OF HEPATOLOGY

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice

(2012) Veerle Bieghs et al.   GASTROENTEROLOGY

Cholesterol and nonalcoholic fatty liver disease: Renewed focus on an old villain

(2012) Thomas A. Kerr et al.   HEPATOLOGY

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Dyslipidemia in Patients with Nonalcoholic Fatty Liver Disease

(2012) Hemant Chatrath et al.   SEMINARS IN LIVER DISEASE

The Role of MicroRNAs in Cholesterol Efflux and Hepatic Lipid Metabolism

(2011) Kathryn J. Moore et al.   Annual Review of Nutrition

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis

(2011) Lei Zhao et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

SREBP-2: A link between insulin resistance, hepatic cholesterol, and inflammation in NASH

(2011) Derrick M Van Rooyen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

(2011) Savitha Subramanian et al.   JOURNAL OF LIPID RESEARCH

MicroRNAs and liver disease

(2011) Thomas A. Kerr et al.   Translational Research

Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity

(2010) Piia Simonen et al.   JOURNAL OF HEPATOLOGY

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

(2010) André J. Tremblay et al.   JOURNAL OF LIPID RESEARCH

Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet

(2010) Tomonori Muraoka et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A comprehensive definition for metabolic syndrome

(2009) P. L. Huang   Disease Models & Mechanisms

Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine

(2009) Lydia Lee et al.   HEPATOLOGY

Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the united states population

(2009) George N. Ioannou et al.   HEPATOLOGY

Down-Regulation of Hepatic HNF4α Gene Expression during Hyperinsulinemia via SREBPs

(2009) Xuefen Xie et al.   MOLECULAR ENDOCRINOLOGY

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia

(2008) John J.P. Kastelein et al.   NEW ENGLAND JOURNAL OF MEDICINE