Review
Oncology
Ruchi Shah, Puja G. Khaitan, Tej K. Pandita, Adnan Rafiq, Deepak Abrol, Jyotsna Suri, Sandeep Kaul, Rakesh Kumar, Swarkar Sharma
Summary: Gastric carcinoma is a common malignancy with a heterogeneous nature, and its incidence is particularly high in the northeastern region and Kashmir Valley of India, possibly due to genetic factors.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Upasana Ray, Deok-Beom Jung, Ling Jin, Yinan Xiao, Subramanyam Dasari, Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Julie K. Staub, Debarshi Roy, Bhaskar Roy, S. John Weroha, Xiaonan Hou, James W. Purcell, Jamie N. Bakkum-Gamez, Scott H. Kaufmann, Nagarajan Kannan, Anirban K. Mitra, Viji Shridhar
Summary: This study identifies the role of LRRC15 in promoting ovarian cancer metastasis and demonstrates that the LRRC15-targeted antibody-drug conjugate can suppress ovarian cancer metastasis.
Article
Multidisciplinary Sciences
Hua Ma, Zhihui He, Jing Chen, Xu Zhang, Pingping Song
Summary: This study identified 11 hub genes associated with gastric cancer, with functions enriched in cellular senescence, cell cycle, viral carcinogenesis, and the p53 signaling pathway. Ten of these genes were found to be related to overall survival in GC patients, and seven were significantly correlated with GC, potentially serving as prognostic biomarkers.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Upasana Ray, Christopher L. Pathoulas, Prabhu Thirusangu, James W. Purcell, Nagarajan Kannan, Viji Shridhar
Summary: Abundant fibrotic stroma is a common feature in solid tumors, and targeting the tumor stroma, including the overexpressed LRRC15 protein, has become a promising therapeutic strategy. Effective LRRC15-targeted therapy may improve outcomes for patients with LRRC15-positive tumors, offering personalized clinical benefits and predictive biomarkers for preclinical assessment.
Article
Oncology
Cheng Xu, Yulin Chen, Feiwu Long, Junman Ye, Xue Li, Qiaorong Huang, Dejiao Yao, Xiaoli Wang, Jin Zhao, Wentong Meng, Xianming Mo, Ran Lu, Chuanwen Fan, Tao Zhang
Summary: In this study, it was found that LRRN4 is highly expressed in colorectal cancer and is positively correlated with clinical outcomes. LRRN4 plays an important role in promoting cell proliferation, DNA synthesis, cell migration, and inhibiting apoptosis.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Tomofumi Ando, Ikue Tai-Nagara, Yuki Sugiura, Dai Kusumoto, Koji Okabayashi, Yasuaki Kido, Kohji Sato, Hideyuki Saya, Sutip Navankasattusas, Dean Y. Li, Makoto Suematsu, Yuko Kitagawa, Elena Seiradake, Satoru Yamagishi, Yoshiaki Kubota
Summary: Blood vessel abnormalities in cancer can be targeted therapeutically to suppress cancer progression, according to a study. Researchers found that a molecule called fibronectin leucine-rich transmembrane protein 2 (FLRT2) is expressed in abnormal blood vessels of advanced colorectal cancers in humans. Deleting FLRT2 in endothelial cells selectively pruned abnormal blood vessels and suppressed tumor metastasis. Additionally, FLRT2 deletion increased the number of mature vessels, enhancing the antitumor effects of immune checkpoint blockers. The study suggests that targeting tumor-specific interendothelial adhesions could be a safe and effective therapeutic option.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Oncology
Ryota Ando, Akihiro Sakai, Tadashi Iida, Kunio Kataoka, Yasuyuki Mizutani, Atsushi Enomoto
Summary: Recent research has shown that cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC) have diverse states and plasticity, which can either suppress or promote cancer progression. These heterogeneous CAFs also affect the sensitivity of PDAC to anticancer therapeutics. Further studies are needed to understand the roles of CAFs in disease progression and to develop therapeutics that modulate the tumor microenvironment in PDAC.
Article
Oncology
Gh. Rasool Bhat, Rajeshwer Singh Jamwal, Itty Sethi, Amrita Bhat, Ruchi Shah, Sonali Verma, Minerva Sharma, Hana Q. Sadida, Sara K. Al-Marzooqi, Tariq Masoodi, Sameer Mirza, Mohammad Haris, Muzafar A. Macha, Ammira S. Alshabeeb Akil, Ajaz A. Bhat, Rakesh Kumar
Summary: This study highlights the important relationship between genetic variation in telomere maintenance genes, telomere attrition, and NSCLC risk in the population of Jammu and Kashmir, North India. The study found significant associations between specific variants in TERT and POT1 genes and NSCLC risk, as well as significantly shorter telomere lengths in NSCLC patients. These findings suggest that TERT and POT1 gene variants, along with telomere length, may serve as potential biomarkers and therapeutic targets for NSCLC in this population.
Article
Oncology
Rajeshwer Singh Jamwal, Nikita Mahajan, Gh Rasool Bhat, Amrita Bhat, Ruchi Shah, Sonali Verma, Minerva Sharma, Bhawani Sharma, Raies A. Qadri, Rakesh Kumar, Audesh Bhat
Summary: This study identified a significant association between REV3L gene polymorphisms and the risk of non-small cell lung cancer (NSCLC) in the North Indian population, suggesting a potential role of these variants in increasing the risk for NSCLC development. These findings support the use of these variants as potential genetic predisposition markers for NSCLC.
CANCER EPIDEMIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jihee Lee, Kyoungwha Pang, Junil Kim, Eunji Hong, Jeeyun Lee, Hee Jin Cho, Jinah Park, Minjung Son, Sihyun Park, Minjung Lee, Akira Ooshima, Kyung-Soon Park, Han-Kwang Yang, Kyung-Min Yang, Seong-Jin Kim
Summary: The epithelial and mesenchymal isoform switches of LRRFIP2, regulated by ESRP1, are closely related to the metastatic potential of gastric cancer cells. The epithelial isoform of LRRFIP2 inhibits the oncogenic function of CARM1, while the mesenchymal isoform promotes liver metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Bhanu Sharma, Shabab Angurana, Ruchi Shah, Sonali Verma, Amrita Bhat, Divya Bakshi, Rajeshwer Singh Jamwal, Mukesh Tanwar, Supinder Singh, Audesh Bhat, Samantha Vaishnavi, Rakesh Kumar
Summary: The study aimed to investigate the association of the rs10740055 variant of the ARID5B gene with CRC in the population of J&K, showing that the rs10740055 variant increases the risk of colorectal cancer, and a larger sample size is needed for further validation.
GENES & GENETIC SYSTEMS
(2021)
Review
Chemistry, Multidisciplinary
Udeep Chawla, Deepak Chopra
Summary: The structural advancement in Shoc2 protein suggests that it may exhibit a dimer or higher order oligomer structure during its scaffolding activity, providing a new perspective for drug development in treating cancer and other diseases.
Article
Medicine, Research & Experimental
Fang Liang, Hao Zhang, Duo Cheng, Hui Gao, Junyong Wang, Junmin Yue, Nan Zhang, Jingjing Wang, Zhaoyang Wang, Beibei Zhao
Summary: The study suggests that LGR4 plays an important regulatory role in radiation sensitivity in prostate cancer cells, with its expression being influenced by radiation treatment and affecting cell proliferation, apoptosis, and DNA damage repair gene expression. Additionally, LGR4 knockdown also impacts androgen receptor and cyclic AMP response-element binding protein expression.
Article
Oncology
Lei Meng, Yu-Ting Hu, A-Man Xu
Summary: This study found that FBXL6 expression is increased in gastric cancer tissues and positively correlated with clinicopathological characteristics. Experimental results showed that silencing FBXL6 inhibited proliferation and migration of gastric cancer cells, and affected the epithelial-mesenchymal transition pathway through the expression of related proteins. Therefore, FBXL6 may serve as a potential target for diagnosis and targeted therapy of gastric cancer.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Samah Abdulaali Alharbi, Dmitry A. Ovchinnikov, Ernst Wolvetang
Summary: Colon cancer cell lines contain tumor stem cells with properties similar to normal intestinal stem cells, and the identification and isolation of these stem cells can aid in drug screening and understanding tumor development. The existence of different stem cell compartments in colon cancer cell lines underscores the importance of considering this heterogeneity in research and drug screening.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Urology & Nephrology
Harshit Garg, Prabhjot Singh, Brusabhanu Nayak, Rishi Nayyar, Seema Kaushal, Rajeev Kumar, Amlesh Seth
Summary: Cystitis cystica et glandularis is a rare clinic pathological entity that often mimics bladder tumors. It is more common in men and presents with lower urinary tract symptoms. Transurethral resection is the main treatment method, but it is often associated with upper tract hydronephrosis. Close surveillance is necessary due to its controversial premalignant nature, recurrence, and risk of upper tract deterioration.
JOURNAL OF CLINICAL UROLOGY
(2023)
Article
Horticulture
Rohan Kumar Raman, Dhiraj Kumar Singh, Sudip Sarkar, Jaspreet Singh, Abhay Kumar, Ujjwal Kumar, Rakesh Kumar, Akram Ahmed, Anirban Mukharjee, Surajit Mondal, Ashutosh Upadhyaya, P. S. Brahmanand
Summary: This study analyzed the production trends of major fruit crops in Bihar and found a significant increasing trend in banana production. Zone I and IIIB in Bihar produced significantly more fruit than other zones. The study results can help researchers and policy makers identify low productivity areas and improve productivity to support sustainable income for farmers in flood-prone areas.
Editorial Material
Pharmacology & Pharmacy
Aditya Prakash Sharma, Rajeev Kumar
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Engineering, Electrical & Electronic
Atish Kumar Sharma, Nitesh K. Chourasia, Prakash Kumar Jha, Rakesh Kumar, Manish Kumar, Ritesh Kumar Chourasia
Summary: Organic solar cells are gaining research interest due to their lower pollution compared to traditional solar cells. In this study, the parameters of the PTB7:PC71BM active layer were optimized, and graphene oxide and PFN:Br were used as the hole and electron transport layers respectively. The highest power conversion efficiency of 15.31% was achieved at an active layer electron affinity of 3.9eV. The effects of electron and hole mobility, as well as series and shunt resistance, were analyzed.
JOURNAL OF ELECTRONIC MATERIALS
(2023)
Article
Mathematics, Applied
Rupali Kaushal, Garima Gupta, Rashmi Sachdeva, Rakesh Kumar
Summary: This paper studies conformal slant Riemannian maps and umbilical conformal slant Riemannian maps from nearly Kaehler manifolds to Riemannian manifolds, and derives necessary and sufficient conditions for such maps to be harmonic. Later, it studies conformal slant Riemannian maps with totally umbilical fibers. Finally, it presents some non-trivial examples of conformal slant Riemannian maps from non-Kaehlerian nearly Kaehler manifold S6 to Riemannian manifolds.
MEDITERRANEAN JOURNAL OF MATHEMATICS
(2023)
Editorial Material
Endocrinology & Metabolism
Audesh Bhat, Arti Dhar, Kaushik Desai
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Bei Zhou, Weiguang He, Jasmine Kaur, Qingxia Cai, Audesh Bhat, Qiang Liu
Summary: This meta-analysis evaluates the accuracy of abbreviated magnetic resonance imaging (ABB-MRI) in the diagnosis of breast cancer. The results show that ABB-MRI has high sensitivity and specificity in detecting breast cancer, making it a useful tool for the accurate detection of malignant lesions in high-risk women that cannot be detected by mammography or ultrasound.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Azmi Khan, Ashutosh Singh, Pratika Singh, Rakesh Kumar, Krishna Kumar Ojha, Vijay Kumar Singh, Amrita Srivastava
Summary: Microorganisms produce siderophores to acquire iron, while the mammalian immune system produces lipocalins to sequester these siderophores from invading bacterial pathogens. Lipocalins can also transport siderophore-bound iron to host cells. However, the binding of fungal siderophores with human lipocalins is still not fully understood. This study investigates the expression of human lipocalin and its binding with fungal siderophore, as well as the potential mechanism of siderophore-mediated cell death in hepatocellular carcinoma.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Engineering, Electrical & Electronic
Prakash Kumar Jha, Nitesh K. K. Chourasia, Ankita Srivastava, Atish Kumar Sharma, Rakesh Kumar, Subhash Sharma, Manish Kumar, Ritesh Kumar Chourasia
Summary: This research proposes a lead-free hybrid solar cell with CH3NH3SnI3 as the absorber layer, Cu2O as the hole transport layer, TiO2 as the electron transport layer, and FTO as the transparent conducting oxide layer. Simulation studies show that a temperature of 305 K and a Gaussian peak defect density of 1.079 x 10(16) cm(-3) in the absorber layer can achieve the best performance. The results suggest that this analysis may open up new possibilities for clean energy.
JOURNAL OF ELECTRONIC MATERIALS
(2023)
Article
Optics
Rakesh Ranjan Kumar, Lars Nielsen, Nicolas Volet, Martijn J. R. Heck
Summary: We present a study on the intra-cavity coherent combining of two DBR lasers on an InP platform, achieving a combining efficiency of 84%. The combined DBR lasers exhibit an on-chip power of 9.5 mW at an injection current of 42 mA in both gain sections simultaneously. This monolithic approach enables the operation of compact and high-power lasers in a single-mode regime with a side-mode suppression ratio of 38 dB, providing a promising direction for integrated photonic technologies.
Article
Agronomy
Swati Walia, Pawan Kumar, Dinesh Kumar, Rakesh Kumar
Summary: This study investigates the growth characteristics and ginsenoside content in the roots of Panax ginseng cultivated in Lahaul & Spiti, Himachal Pradesh, India. The results show that plant growth parameters increase with crop age and reach maximum maturity at five years, along with increased production of seeds and roots. The HPLC analysis reveals 14 compounds representing a total ginsenoside content of 31.81 +/- 2.89 mg/g, with Rb1, Rg2, and Re identified as major ginsenosides. The soil and climate of the Lahaul and Spiti district in Himachal Pradesh are found to be suitable for cultivating P. ginseng with high ginsenoside content in five-year-old roots.
PLANT SOIL AND ENVIRONMENT
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Kunal Ramesh Chandekar, Swayamjeet Satapathy, Sridhar Panaiyadiyan, Rakesh Kumar
Summary: PSMA PET/CT is increasingly used for evaluating prostate cancer. We present a case of a 50-year-old man with high-risk PCa, in which Ga-68-PSMA-11 PET/CT identified multiple active perirenal fascia metastases, in addition to prostatic primary, nodal, and skeletal metastases. This case highlights the uncommon metastatic site of perirenal fascia in PCa.
NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Ankit Sachan, Prashant Singh, Seema Kaushal, Rajeev Kumar
Summary: A man in his 50s presented with shortness of breath and was found to have a large paracaval mass, which was further evaluated using CT scan and showed a large heterogeneously enhancing mass lesion adjacent to the right renal hilum. Ga-68-DOTATATE positron emission tomography/CT revealed avidity in the lesion with a maximum standardised uptake value of 16.5. Surgical excision of the mass with nephrectomy was performed and histopathological examination confirmed the diagnosis of hyaline vascular Castleman disease.
Article
Biochemistry & Molecular Biology
Jegadheeswari Venkadakrishnan, Ganesh Lahane, Arti Dhar, Wei Xiao, Krishna Moorthi Bhat, Tej K. Pandita, Audesh Bhat
Summary: DNA damage tolerance (DDT) pathway suppresses replication fork arrest-induced DNA double strand breaks (DSBs) through translesion DNA synthesis (TLS) and homology-directed DDT mechanisms, with TLS polymerases playing a crucial role. Defects in TLS pathway can lead to various diseases. Apart from their role in DDT pathway, noncanonical functions of TLS polymerases are also important for maintaining genomic stability.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Review
Oncology
Minerva, Amrita Bhat, Sonali Verma, Gresh Chander, Rajeshwer Singh Jamwal, Bhawani Sharma, Audesh Bhat, Taruna Katyal, Rakesh Kumar, Ruchi Shah
Summary: Cisplatin is a drug commonly used for the treatment of solid tumors and malignancies, but it comes with adverse effects and drug resistance. Combination drug therapy has been considered as a solution to overcome these issues.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
