Article
Oncology
Yan Zou, Yunyan Du, Cheng Cheng, Xueqiang Deng, Zimin Shi, Xiongbing Lu, Honglin Hu, Jun Qiu, Weifan Jiang
Summary: FAT10 and HK2 proteins are significantly elevated in bladder cancer tissues compared to normal adjacent tissues, and FAT10 promotes bladder cancer progression by positively regulating HK2 levels.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Liliang Shen, Junfeng Zhang, Zongtai Zheng, Fuhan Yang, Shenghua Liu, Yuan Wu, Yifan Chen, Tianyuan Xu, Shiyu Mao, Yang Yan, Wei Li, Wentao Zhang, Xudong Yao
Summary: The study revealed that PHGDH upregulates SLC7A11 expression via interaction with PCBP2, inhibiting ferroptosis and promoting malignant progression of BCa. The findings suggest that NCT-502 could be a potential therapeutic strategy for BCa.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Chuanming Tong, Chuan Wang, Yajie Wang, Xiongsheng Xiao
Summary: TNRC6C-AS1 regulates the expression of LPAR5 by competitively adsorbing miR-513c-5p, impacting the progression of thyroid cancer. This novel signaling pathway may serve as a potential target for cancer therapy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Haodong Wang, Huaiping Cui, Xinjun Yang, Lipan Peng
Summary: This study revealed the mechanism of how TUBA1C promotes malignant progression of gastric cancer, that is, by accelerating the progression of the cell cycle and activating the expression of oncogenes. TUBA1C was proved to be a direct target of EGFR-AS1 and it could serve as a potential biomarker and therapeutic target for gastric cancer.
Article
Cell Biology
Qun Lu, Haoli Yin, Yongming Deng, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Yao Fu, Wenjing Mo, Xiaoqing Chen, Qing Zhang, Xiaozhi Zhao, Hongqian Guo
Summary: This study reveals the regulatory mechanism of circDHTKD1 in lymphangiogenesis and lymph node metastasis in bladder cancer. By interacting with miR-149-5p and regulating CXCL5 expression, circDHTKD1 promotes lymphangiogenesis and recruits and activates neutrophils, contributing to lymph node metastasis in bladder cancer.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao, Chao Zhang
Summary: This study found that in colorectal cancer (CRC), the expression of FOXS1 is upregulated and is positively correlated with poor survival. FOXS1 promotes malignant behavior of CRC cells, including proliferation, invasion, and angiogenesis, both in vitro and in vivo. Mechanistically, FOXS1 upregulates the transcriptional level of CXCL8 to regulate tumor growth and metastasis. These findings suggest that the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yong-Sheng Chen, Yong-Peng Xu, Wen-Hua Liu, De-Chao Li, Huan Wang, Chang-Fu Li
Summary: In this study, we identified the elevated expression of KCNMB2-AS1 in bladder cancer for the first time and demonstrated that KCNMB2-AS1 mediated bladder cancer progression by regulating the miR-3194-3p/SAMD5 signaling pathway. These findings provide a novel target for bladder cancer research.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Liping Luo, Pingping Miao, Yao Ming, Jie Tao, Hongchun Shen
Summary: In this study, it was found that the expression of circZFR was upregulated in bladder cancer patients and positively correlated with patient survival rates. Inhibiting circZFR expression suppressed the proliferation, migration, and invasion of BCa cells. Additionally, circZFR was shown to promote BCa progression by upregulating WNT5A expression through sponging miR-545 and miR-1270.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Piao Li, Lingling Li, Zhou Li, Shennan Wang, Ruichao Li, Weiheng Zhao, Yanqi Feng, Shanshan Huang, Lu Li, Hong Qiu, Shu Xia
Summary: The study found that the high expression of ANXA1 in bladder cancer is closely associated with disease progression and prognosis. Silencing ANXA1 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of bladder cancer cells, and suppresses the growth of xenografted bladder tumors. ANXA1 promotes the proliferation and migration of bladder cancer by activating the EGFR signaling pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu, Tao Liu
Summary: This study identified MINDY1 as a deubiquitinating enzyme of YAP in bladder cancer, demonstrating its role in interacting with, deubiquitinating, and stabilizing YAP. Depletion of MINDY1 led to decreased cell proliferation in bladder cancer, which could be rescued by YAP overexpression, affecting the expression of YAP and its target genes.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Feng Guo, Yingke Zhou, Hui Guo, Dianyun Ren, Xin Jin, Heshui Wu
Summary: NR5A2 acts as a negative prognostic biomarker in pancreatic ductal adenocarcinoma (PDAC), being transcriptionally upregulated by BRD4 and promoting pancreatic cancer progression through inducing the transcription of GDF15.
CELL DEATH DISCOVERY
(2021)
Article
Biotechnology & Applied Microbiology
Yang Bai, Chenchen Ren, Baojin Wang, Jingge Xue, Feiyan Li, Jiaxi Liu, Li Yang
Summary: Recent studies have shown that MAFG-AS1 stimulates the malignant progression of OC by upregulating NFKB1-mediated IGF1 via miR-339-5p, highlighting a potential novel therapeutic target against OC.
CANCER GENE THERAPY
(2022)
Article
Oncology
Xingxing Zhang, Xiaojun Zhao, Lihua Chang, Fang Liu, Chunjuan Li, Peng Ge
Summary: This study reveals that FOXD3-AS1 is significantly upregulated in breast cancer and is associated with poor prognosis. The knockdown of FOXD3-AS1 suppresses cell proliferation and metastasis in vitro, as well as tumor growth in vivo. Mechanistically, FOXD3-AS1 functions as a competing endogenous RNA to upregulate ARF6 expression by targeting miR-127-3p. The findings suggest that FOXD3-AS1 plays a crucial role in breast cancer progression.
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
