Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

(2022) Kebria Hezaveh et al.   IMMUNITY

Harnessing cytokines and chemokines for cancer therapy

(2022) David J. Propper et al.   Nature Reviews Clinical Oncology

Tertiary lymphoid structures in cancer

(2022) Ton N. Schumacher et al.   SCIENCE

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Prognosis and tumor biology of pancreatic cancer patients with isolated lung metastases: translational results from the German multicenter AIO-YMO-PAK-0515 study

(2022) S.F. Kruger et al.   ESMO Open

Risk Factors for Pancreatic Cancer: Emerging Role of Viral Hepatitis

(2022) Gina Gheorghe et al.   Journal of Personalized Medicine

Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer

(2022) Emma Kurz et al.   CANCER CELL

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

(2022) Huocong Huang et al.   CANCER CELL

Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

(2022) Yi Liu et al.   Nature Communications

Ipilimumab/Nivolumab Therapy in Patients With Metastatic Pancreatic or Biliary Cancer With Homologous Recombination Deficiency Pathogenic Germline Variants

(2022) Gretel Terrero et al.   JAMA Oncology

Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

(2022) Yang Chen et al.   CANCER CELL

Niraparib plus nivolumab or niraparib plus ipilimumab in patients with platinum-sensitive advanced pancreatic cancer: a randomised, phase 1b/2 trial

(2022) Kim A Reiss et al.   LANCET ONCOLOGY

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

(2022) William L. Hwang et al.   NATURE GENETICS

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial

(2022) Lacey J. Padrón et al.   NATURE MEDICINE

A cancer cell-intrinsic GOT2-PPARd axis suppresses antitumor immunity

(2022) Jaime Abrego et al.   Cancer Discovery

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

(2022) Daniel Cui Zhou et al.   NATURE GENETICS

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

(2021) Xu Wang et al.   Nature Communications

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

KRAS drives immune evasion in a genetic model of pancreatic cancer

(2021) Irene Ischenko et al.   Nature Communications

Tumor cell heterogeneity and its transcriptional bases in pancreatic cancer: a tale of two cell types and their many variants

(2021) Marta Milan et al.   EMBO JOURNAL

Chemokines and the immune response to cancer

(2021) Aleksandra J. Ozga et al.   IMMUNITY

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

(2021) Alison P. Klein   Nature Reviews Gastroenterology & Hepatology

Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

(2021) Shannon M. Liudahl et al.   Cancer Discovery

Estimated Projection of US Cancer Incidence and Death to 2040

(2021) Lola Rahib et al.   JAMA Network Open

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

(2021) Colin Hutton et al.   CANCER CELL

The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

(2021) William A. Freed-Pastor et al.   CANCER CELL

MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

(2021) Bastian Krenz et al.   CANCER RESEARCH

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

(2021) Kazuhiro Koikawa et al.   CELL

Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies

(2021) Jaewon J. Lee et al.   CLINICAL CANCER RESEARCH

Clinical and therapeutic relevance of cancer-associated fibroblasts

(2021) Yang Chen et al.   Nature Reviews Clinical Oncology

Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies

(2021) Ryan J. Sullivan et al.   NATURE REVIEWS DRUG DISCOVERY

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

(2021) Edoardo Del Poggetto et al.   SCIENCE

MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma

(2021) Ravikanth Maddipati et al.   Cancer Discovery

The Cancer Microbiome: Recent Highlights and Knowledge Gaps

(2021) Reece J. Knippel et al.   Cancer Discovery

Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer

(2021) Wei Guo et al.   Communications Biology

Spatially confined sub-tumor microenvironments in pancreatic cancer

(2021) Barbara T. Grünwald et al.   CELL

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

(2021) Srivatsan Raghavan et al.   CELL

Human immune diversity: from evolution to modernity

(2021) Adrian Liston et al.   NATURE IMMUNOLOGY

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

(2020) Michelle Chan-Seng-Yue et al.   NATURE GENETICS

Myc instructs and maintains pancreatic adenocarcinoma phenotype

(2020) Nicole M Sodir et al.   Cancer Discovery

Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment

(2020) Prasenjit Dey et al.   Cancer Discovery

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

(2020) Yaqing Zhang et al.   Cancer Discovery

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy

(2020) Daniel R Principe et al.   CANCER RESEARCH

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

Dietary modifications for enhanced cancer therapy

(2020) Naama Kanarek et al.   NATURE

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Systemic dysfunction and plasticity of the immune macroenvironment in cancer models

(2020) Breanna M. Allen et al.   NATURE MEDICINE

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma

(2020) Nathiya Muthalagu et al.   Cancer Discovery

Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk

(2020) Fangcheng Yuan et al.   CANCER RESEARCH

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix

(2020) Honglin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

(2020) Teresa Manzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

(2020) Valeria Orrù et al.   NATURE GENETICS

Regulation and modulation of antitumor immunity in pancreatic cancer

(2020) Joshua Leinwand et al.   NATURE IMMUNOLOGY

Methylation of immune-regulatory cytokine genes and pancreatic cancer outcomes

(2020) Brian Z Huang et al.   Epigenomics

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study

(2020) Mark H O'Hara et al.   LANCET ONCOLOGY

Molecular subtypes of pancreatic cancer

(2019) Eric A. Collisson et al.   Nature Reviews Gastroenterology & Hepatology

The microbiome, cancer, and cancer therapy

(2019) Beth A. Helmink et al.   NATURE MEDICINE

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma

(2019) Marcus Noel et al.   INVESTIGATIONAL NEW DRUGS

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

(2019) Erick Riquelme et al.   CELL

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

(2019) Aurelien Marabelle et al.   JOURNAL OF CLINICAL ONCOLOGY

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

(2019) Berk Aykut et al.   NATURE

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Integrated genomic and immunophenotypic classification of pancreatic cancer reveals three distinct subtypes with prognostic/predictive significance

(2018) Martin Wartenberg et al.   CLINICAL CANCER RESEARCH

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas

(2018) Alexis Desrichard et al.   JNCI-Journal of the National Cancer Institute

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

CSF1R + Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

(2018) Juliana B. Candido et al.   Cell Reports

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas

(2018) Alexis Desrichard et al.   JNCI-Journal of the National Cancer Institute

Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas

(2018) Isidoro Cobo et al.   NATURE

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

(2018) Sebastian Mueller et al.   NATURE

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

(2018) Ujjwal Mukund Mahajan et al.   GASTROENTEROLOGY

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features

(2018) Francesco Puleo et al.   GASTROENTEROLOGY

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

(2017) Julienne L. Carstens et al.   Nature Communications

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

(2017) Jung-Eun Jang et al.   Cell Reports

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

Key role of pancreatic stellate cells in pancreatic cancer

(2016) Srinivasa P. Pothula et al.   CANCER LETTERS

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Pancreatic cancer microenvironment, to target or not to target?

(2016) R. M. Carr et al.   EMBO Molecular Medicine

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

(2016) Lena Seifert et al.   GASTROENTEROLOGY

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer

(2016) Thomas A Mace et al.   GUT

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Low Stromal Area and High Stromal Microvessel Density Predict Poor Prognosis in Pancreatic Cancer

(2016) Takahiro Nishida et al.   PANCREAS

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

(2016) Francesco Di Maggio et al.   PANCREATOLOGY

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Mutational signatures associated with tobacco smoking in human cancer

(2016) L. B. Alexandrov et al.   SCIENCE

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

(2016) J. Incio et al.   Cancer Discovery

Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer

(2015) N Hiraoka et al.   BRITISH JOURNAL OF CANCER

Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

(2015) S. Takeuchi et al.   CANCER RESEARCH

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

(2015) Gregory L. Beatty et al.   GASTROENTEROLOGY

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study

(2015) Manuela Quaresma et al.   LANCET

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Neural plasticity in pancreatitis and pancreatic cancer

(2015) Ihsan Ekin Demir et al.   Nature Reviews Gastroenterology & Hepatology

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

(2015) R. Winograd et al.   Cancer Immunology Research

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

(2015) Giovanni Francesco Castino et al.   OncoImmunology

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages

(2014) S Kumar et al.   ONCOGENE

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD40 immunotherapy for pancreatic cancer

(2013) Robert H. Vonderheide et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

(2013) D. E. Sanford et al.   CLINICAL CANCER RESEARCH

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

(2013) Ilya Gukovsky et al.   GASTROENTEROLOGY

TGF- : Guardian of T Cell Function

(2013) S. A. Oh et al.   JOURNAL OF IMMUNOLOGY

Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes

(2013) Jehan J. El-Jawhari et al.   MOLECULAR IMMUNOLOGY

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

(2013) M. J. Selby et al.   Cancer Immunology Research

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth

(2012) Matthew R. Porembka et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: A Current Perspective

(2012) D. T. Le et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer

(2012) Donghui Li et al.   CARCINOGENESIS

MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells

(2012) Atsuo Ochi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through  1-Integrin Signaling

(2011) T. S. Mantoni et al.   CANCER RESEARCH

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Acute Pancreatitis Accelerates Initiation and Progression to Pancreatic Cancer in Mice Expressing Oncogenic Kras in the Nestin Cell Lineage

(2011) Catherine Carrière et al.   PLoS One

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Selective Depletion of CD4+CD25+Foxp3+Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels

(2010) Jie Zhao et al.   CANCER RESEARCH

Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer

(2009) A. Blackford et al.   CANCER RESEARCH

Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer

(2009) Andrew V. Biankin et al.   GASTROENTEROLOGY

DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

(2009) Christine A. Iacobuzio-Donahue et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE