Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Authors
Keywords
-
Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-05-13
DOI
10.1038/s41467-022-30392-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice
- (2021) Filippo Veglia et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Early detection of pancreatic cancer using DNA-based molecular approaches
- (2021) Aatur D. Singhi et al. Nature Reviews Gastroenterology & Hepatology
- Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer
- (2020) Pingping Hou et al. Cancer Discovery
- Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study
- (2019) Fabio Grizzi et al. Journal of Translational Medicine
- PPARD and Interferon gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice
- (2019) Xiangsheng Zuo et al. GASTROENTEROLOGY
- Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion
- (2019) Yi Liu et al. CANCER RESEARCH
- Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet
- (2019) Yongde Luo et al. GASTROENTEROLOGY
- Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor
- (2019) Bao-Hua Li et al. MOLECULAR IMMUNOLOGY
- CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
- (2019) Joseph A. Flores-Toro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dietary Fat Stimulates Pancreatic Cancer Growth and Promotes Fibrosis of the Tumor Microenvironment through the Cholecystokinin Receptor
- (2018) Sandeep Nadella et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans
- (2018) Mami Takahashi et al. CANCER SCIENCE
- The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor
- (2018) Yi Liu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia
- (2017) Yoko Matsuda et al. PANCREAS
- Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
- (2017) Hui-Hua Chang et al. PLoS One
- KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis
- (2016) Daoyan Wei et al. CANCER CELL
- Genetics and biology of pancreatic ductal adenocarcinoma
- (2016) Haoqiang Ying et al. GENES & DEVELOPMENT
- Pancreatic cancer
- (2016) Terumi Kamisawa et al. LANCET
- Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
- (2016) Anna-Maria Georgoudaki et al. Cell Reports
- 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway
- (2015) Fei Mao et al. FASEB JOURNAL
- Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
- (2014) Ingunn M Stromnes et al. GUT
- Peroxisome proliferator-activated receptor promotes colonic inflammation and tumor growth
- (2014) D. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model
- (2013) D. W. Dawson et al. Cancer Prevention Research
- Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
- (2013) Y. Zhang et al. CANCER RESEARCH
- Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
- (2013) D. E. Sanford et al. CLINICAL CANCER RESEARCH
- A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice
- (2013) Bincy Philip et al. GASTROENTEROLOGY
- Roles for KRAS in Pancreatic Tumor Development and Progression
- (2013) Marina Pasca di Magliano et al. GASTROENTEROLOGY
- Oncogenic K-Ras requires activation for enhanced activity
- (2013) H Huang et al. ONCOGENE
- Role of Peroxisome Proliferator-Activated Receptorβ/δand B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells
- (2013) Jeffrey D. Coleman et al. PPAR Research
- Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
- (2012) Lauren J. Bayne et al. CANCER CELL
- Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
- (2012) J. B. Mitchem et al. CANCER RESEARCH
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
- (2012) Haoqiang Ying et al. CELL
- Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
- (2012) Mitsuro Kanda et al. GASTROENTEROLOGY
- Activation of Nuclear Factor-κB in Acinar Cells Increases the Severity of Pancreatitis in Mice
- (2012) Haojie Huang et al. GASTROENTEROLOGY
- An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice
- (2012) Jaroslaw Daniluk et al. JOURNAL OF CLINICAL INVESTIGATION
- Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion
- (2012) T Adhikary et al. ONCOGENE
- Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia
- (2011) Yun-Jung Choi et al. ATHEROSCLEROSIS
- STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
- (2011) R. B. Corcoran et al. CANCER RESEARCH
- Enhancement of Carcinogenesis and Fatty Infiltration in the Pancreas in N-Nitrosobis(2-Oxopropyl)Amine-Treated Hamsters by High-Fat Diet
- (2011) Mika Hori et al. PANCREAS
- Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist
- (2011) Chu-Biao Xue et al. ACS Medicinal Chemistry Letters
- Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
- (2010) K. Movahedi et al. CANCER RESEARCH
- Ras Activity Levels Control the Development of Pancreatic Diseases
- (2009) Baoan Ji et al. GASTROENTEROLOGY
- Mutated K-rasAsp12promotes tumourigenesis inApcMinmice more in the large than the small intestines, with synergistic effects between K-rasandWntpathways
- (2009) Feijun Luo et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Dietary Fatty Acids and Pancreatic Cancer in the NIH-AARP Diet and Health Study
- (2009) Anne C. M. Thiébaut et al. JNCI-Journal of the National Cancer Institute
- Inflammation and mitochondrial fatty acid -oxidation link obesity to early tumor promotion
- (2009) J. Khasawneh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peroxisome Proliferator–Activated Receptor β/δ Expression and Activation in Lung Cancer
- (2008) Tetyana V. Pedchenko et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now