Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
Authors
Keywords
pancreatic cancer, immunology, T cell, exercise, immunotherapy, IL-15, super-agonist, checkpoint blockade, PD-1
Journal
CANCER CELL
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2022-06-02
DOI
10.1016/j.ccell.2022.05.006
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models
- (2021) Siqi Guo et al. Frontiers in Immunology
- Exercise Training Improves Tumor Control by Increasing CD8+ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade
- (2021) Igor L. Gomes-Santos et al. Cancer Immunology Research
- Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy
- (2021) Seo Rin Kim et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
- (2021) Chaobao Liu et al. Nature Communications
- Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer
- (2020) Shipra Das et al. CANCER RESEARCH
- Combining microenvironment normalization strategies to improve cancer immunotherapy
- (2020) Fotios Mpekris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exercise reduces immune suppression and breast cancer progression in a preclinical model
- (2020) Erik Wennerberg et al. Oncotarget
- Alterations in the innate immune system due to exhausting exercise in intensively trained rats
- (2020) Sheila Estruel-Amades et al. Scientific Reports
- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
- (2020) Jean-Christophe Beltra et al. IMMUNITY
- Phase I study of SEA-CD40, gemcitabine, nab-paclitaxel, and pembrolizumab in patients with metastatic pancreatic ductal adenocarcinoma (PDAC).
- (2020) Andrew L. Coveler et al. JOURNAL OF CLINICAL ONCOLOGY
- Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
- (2020) Breanna M. Allen et al. NATURE MEDICINE
- Open-label, Phase I Study of Nivolumab Combined with nab-Paclitaxel Plus Gemcitabine in Advanced Pancreatic Cancer
- (2020) Zev A. Wainberg et al. CLINICAL CANCER RESEARCH
- Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis
- (2020) Jeffrey H. Lin et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Generalizing RNA velocity to transient cell states through dynamical modeling
- (2020) Volker Bergen et al. NATURE BIOTECHNOLOGY
- Physical activity delays accumulation of immunosuppressive myeloid-derived suppressor cells
- (2020) Jacob Garritson et al. PLoS One
- Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion
- (2020) Jingxia Wu et al. Science Advances
- Challenges and Opportunities for Pancreatic Cancer Immunotherapy
- (2020) Adham S. Bear et al. CANCER CELL
- Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
- (2020) Helene Rundqvist et al. eLife
- Mechanisms of T-Cell Exhaustion in Pancreatic Cancer
- (2020) Didem Saka et al. Cancers
- Broadening the impact of immunotherapy to pancreatic cancer: Challenges and opportunities
- (2019) Vinod P. Balachandran et al. GASTROENTEROLOGY
- Chronic virus infection compromises memory bystander T cell function in an IL-6/STAT1-dependent manner
- (2019) Isabel Barnstorf et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer
- (2019) Lei Wang et al. NATURE IMMUNOLOGY
- Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma
- (2019) Eileen M. O’Reilly et al. JAMA Oncology
- Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
- (2019) Erick Riquelme et al. CELL
- Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2019) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3
- (2019) Xiaoqing Han et al. Cell Death & Disease
- Blockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy
- (2019) Clara Daher et al. Cancer Immunology Research
- TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
- (2019) Zeyu Chen et al. IMMUNITY
- Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
- (2019) Vanessa Frodermann et al. NATURE MEDICINE
- Exercise during preoperative therapy increases tumor vascularity in pancreatic tumor patients
- (2019) Claudia Alvarez Florez Bedoya et al. Scientific Reports
- Increased regulatory B cells are involved in immune evasion in patients with gastric cancer
- (2019) Yuki Murakami et al. Scientific Reports
- Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches
- (2019) Anita Thyagarajan et al. Cancers
- Better Together: B7S1 Checkpoint Blockade Synergizes with anti-PD1
- (2018) Melissa A. Meyer et al. IMMUNITY
- ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial
- (2018) John M Wrangle et al. LANCET ONCOLOGY
- Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
- (2018) Melissa A. Meyer et al. Nature Communications
- Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
- (2018) Annan Yang et al. Cancer Discovery
- Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment
- (2018) Etienne D. Foucher et al. Frontiers in Immunology
- RNA velocity of single cells
- (2018) Gioele La Manno et al. NATURE
- The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent
- (2018) Chloé Grasselly et al. Frontiers in Immunology
- Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
- (2017) Alberto Yáñez et al. IMMUNITY
- Home-based exercise during preoperative therapy for pancreatic cancer
- (2017) An Ngo-Huang et al. LANGENBECKS ARCHIVES OF SURGERY
- Single-cell mRNA quantification and differential analysis with Census
- (2017) Xiaojie Qiu et al. NATURE METHODS
- Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- (2017) V. Gopalakrishnan et al. SCIENCE
- Identification and causes of metabonomic difference between orthotopic and subcutaneous xenograft of pancreatic cancer
- (2017) Bohan Zhan et al. Oncotarget
- The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade
- (2017) Howard Y. Li et al. Cancer Immunology Research
- A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer
- (2016) B. H. O'Neil et al. ANNALS OF ONCOLOGY
- Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data
- (2016) Kathleen A. Ashcraft et al. CANCER RESEARCH
- Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution
- (2016) Line Pedersen et al. Cell Metabolism
- IL-15Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists
- (2016) Mélanie Desbois et al. JOURNAL OF IMMUNOLOGY
- The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
- (2016) Vinit Kumar et al. TRENDS IN IMMUNOLOGY
- Exercise-Dependent Regulation of NK Cells in Cancer Protection
- (2016) Manja Idorn et al. TRENDS IN MOLECULAR MEDICINE
- Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy
- (2016) Keri L. Schadler et al. Oncotarget
- How Do Cytotoxic Lymphocytes Kill Cancer Cells?
- (2015) L. Martinez-Lostao et al. CLINICAL CANCER RESEARCH
- A map of the distribution of sphingosine 1-phosphate in the spleen
- (2015) Willy D Ramos-Perez et al. NATURE IMMUNOLOGY
- Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma
- (2015) R. Winograd et al. Cancer Immunology Research
- An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma
- (2014) Yichen Tang et al. PLoS One
- Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients
- (2014) W.-C. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
- (2013) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor
- (2010) Ilaria Marigo et al. IMMUNITY
- Selective Mobilization of Cytotoxic Leukocytes by Epinephrine
- (2009) Stoyan Dimitrov et al. JOURNAL OF IMMUNOLOGY
- High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor fusion protein, in metastatic melanoma and colorectal cancer
- (2009) A. Bessard et al. MOLECULAR CANCER THERAPEUTICS
- Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus StatementStandard Operating Procedure Integration Working Group
- (2008) Melissa K. Tuck et al. JOURNAL OF PROTEOME RESEARCH
- Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms
- (2007) K. Krüger et al. BRAIN BEHAVIOR AND IMMUNITY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More