Review
Cell Biology
Jenying Deng, Jason B. Fleming
Summary: Most immunotherapy drugs target T cell surface proteins to enhance their tumor-killing activity, but this approach has limited success in certain solid tumors. Myeloid-related innate immunity plays a role in tumor progression and understanding this field may lead to new therapeutic options. Myeloid cells can differentiate into pro-inflammatory or anti-inflammatory forms depending on the tumor microenvironment. In this review, the relationship between cancer cells and myeloid cells in the tumor immune microenvironment, and the development of immunotherapeutic strategies targeting myeloid-related innate immunity will be discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Botao Wang, Lei Yang, Tianyu Liu, Jing Xun, Yuzhen Zhuo, Lanqiu Zhang, Qi Zhang, Ximo Wang
Summary: Hydroxytyrosol (HT) inhibits the proliferation of pancreatic cancer cells and modulates the immune microenvironment, showing potential as an immunomodulatory drug for the treatment of pancreatic cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Zhuo Shao, Chenggang Li, Qiao Wu, Xingmao Zhang, Yang Dai, Shenming Li, Xinyuan Liu, Xinying Zheng, Jiansheng Zhang, Hua Fan
Summary: This study evaluated the clinical value, biological function, and underlying mechanisms of Zinc finger protein 655 (ZNF655) in human pancreatic cancer. Results showed that ZNF655 expression was elevated in pancreatic cancer and had clinical value in predicting poor prognosis. Functional assays demonstrated that ZNF655 knockdown inhibited the progression of pancreatic cancer cells. Mechanistically, ZNF655 played a role in promoting the binding of E2F1 to the CDK1 promoter. These findings suggest that ZNF655 may be a potential therapeutic target for pancreatic cancer.
Article
Pharmacology & Pharmacy
Hongbo Zhang, Yuzhen Zhuo, Dihua Li, Lanqiu Zhang, Qiaoying Gao, Lei Yang, Xiangfei Yuan
Summary: This study aimed to investigate the effect of Dihydroartemisinin (DHA) on inducing ferroptosis and activating anti-tumor immunity and the underlying molecular mechanism. The results showed that DHA inhibited pancreatic cancer cell proliferation and induced cell ferroptosis by up-regulating the expression of P53 and ALOX12, while also up-regulating the expression of GPX4 and SLC7A11. Furthermore, DHA reduced the suppressive expansion of M2 and MDSCs, and increased the population of CD8(+)T cells, NK cells and NKT cells in tumor tissues.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen
Summary: Emodin can improve diabetic wound healing by promoting extracellular matrix synthesis and granulation tissue formation, and promote the conversion of M1-like macrophages to M2-like macrophages by down-regulating the NF-xB signaling pathway. This study identified potential targets of emodin and revealed its role in fibroblast proliferation and ECM formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Cheng Xiong, Youwei Zhu, Meilin Xue, Yongsheng Jiang, Yiming Zhong, Lingxi Jiang, Minmin Shi, Hao Chen
Summary: This study revealed that TAMs promote PDAC progression through the TGF-beta signaling pathway, and the pro-tumorigenic effects of TAMs or TAM-CM can be abolished by inhibiting the TGF-beta signaling pathway or neutralizing TGF-beta antibody.
Article
Oncology
Lumin Wang, Yi Gao, Dongdong Tong, Xiaofei Wang, Chen Guo, Bo Guo, Yang Yang, Lingyu Zhao, Jing Zhang, Juan Yang, Yannan Qin, Liying Liu, Chen Huang
Summary: The study revealed the function of the MeCP2/HOXD3/HB-EGF regulatory axis in HCC, providing insights for the development of targeted therapeutics and potential biomarkers. The expression of HOXD3 gene is regulated by the cooperative action of MeCP2 and CREB1, leading to promotion of HCC metastasis, invasion, and angiogenesis.
MOLECULAR ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hang Su, Yu Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasunaga Shiraishi, Pingping Hu, Richard A. Cohen, Xiaoyong Tong
Summary: The substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. This study highlights the importance of SERCA2 C674 redox state in the context of atherosclerosis and proposes a novel therapeutic strategy to combat atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Akbar Nawab, Michael W. Dougherty, Christian Jobin, Iqbal Mahmud, Timothy J. Garrett, Michael Feely, Kyoung Bun Lee, Frederic J. Kaye, Maria V. Guijarro, Maria Zajac-Kaye
Summary: Clinical studies have shown that overexpression or amplification of thymidylate synthase (TS) in cancer patients is associated with worse clinical outcomes. This study generated a mouse model with elevated human TS (hTS) and conditional inactivation of the Men1 gene and found that increased hTS expression accelerated PanNET development and reduced overall survival. Furthermore, high TS protein expression was independently associated with worse clinical outcomes in PanNET patients.
Article
Biochemistry & Molecular Biology
Chongbiao Huang, Hui Li, Yang Xu, Chao Xu, Huizhi Sun, Zengxun Li, Yi Ge, Hongwei Wang, Tiansuo Zhao, Song Gao, Xiuchao Wang, Shengyu Yang, Peiqing Sun, Zhe Liu, Jing Liu, Antao Chang, Jihui Hao
Summary: VEGF inhibitors have been successful in treating solid tumors, but pancreatic adenocarcinoma (PAAD) cells can activate VEGF-independent pathways to reinstate tumor angiogenesis, leading to resistance to VEGF inhibitors. BICC1 is a top gene involved in PAAD-specific angiogenesis. Overexpression of BICC1 in human PAAD tissues is associated with increased microvessel density, tumor growth, and worse prognosis. BICC1 promotes angiogenesis in pancreatic cancer through a VEGF-independent mechanism. Its binding to LCN2 mRNA up-regulates LCN2 expression, leading to the activation of the JAK2/STAT3 signal pathway and increased production of the angiogenic factor CXCL1. Blocking the BICC1/LCN2 signaling reduces microvessel density and tumor volume, and enhances the suppressive effect of gemcitabine. BICC1/LCN2 signaling may be a promising therapeutic target for anti-angiogenesis in pancreatic cancer patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Oncology
Peitao Wu, Yuhang Guo, Li Xiao, Jiaqi Yuan, Chao Tang, Jun Dong, Zhiyuan Qian
Summary: This study reveals that LILRB2 can be transferred between GBM cells through sEVs, and pirb on sEVs promotes the formation and expansion of MDSCs, facilitating the establishment of an immunosuppressive tumor microenvironment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Langtao Wang, Zhen Yang, Sai Wang, Yumei Que, Xi Shu, Fuhua Wu, Gang Liu, Siqi Li, Pingping Hu, Hao Chen, Jian Shi, Xiaoyong Tong
Summary: This study found that the irreversible oxidation of SERCA2 C674 promotes the development of aortic aneurysm by inducing endoplasmic reticulum stress and cell apoptosis. Additionally, ER stress and SERCA2 may be potential therapeutic targets for treating aortic aneurysm.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Chia -Hui Chen, Bei-Chia Guo, Po-An Hu, Hsueh-Te Lee, Hsuan-Yun Hu, Man-Chen Hsu, Wen-Hua Chen, Tzong-Shyuan Lee
Summary: Ractopamine, a synthetic agonist used as an animal feed additive, has been found to accelerate atherosclerosis progression by inducing endothelial dysfunction and dysregulating cholesterol metabolism of macrophages, as shown in experiments on mice and cells.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cell Biology
Xinjian Liu, Hao Yuan, Jing Zhou, Qiongling Wang, Xiaoqiang Qi, Catharine Bernal, Diego Avella, Jussuf T. Kaifi, Eric T. Kimchi, Parrett Timothy, Kun Cheng, Yi Miao, Kuirong Jiang, Guangfu Li
Summary: The study identified LIM domain only 7 (LMO7) as a potential target for developing targeted therapy for pancreatic cancer, as loss of LMO7 function significantly suppresses tumor growth and metastasis. This suggests that LMO7 could be an important unrecognized druggable factor in impacting pancreatic cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Yan Jin, Runze Wu, Li Li, Lihua Shen, Yunjuan Gu, Cheng Sun
Summary: Inflammation is a common feature in both Parkinson's disease and obesity-associated metabolic syndromes. Exosomes derived from inflamed macrophages may be involved in the pathological progression of Parkinson's disease. These exosomes stimulate proinflammatory cytokine expression and induce PD-like phenotypes in mouse models.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Organic
Smita. G. Mane, Kariyappa. S. Katagi, Nikhil. S. Kadam, Mahesh. C. Akki, Shrinivas. D. Joshi
Summary: A series of novel acridine-thiazole bridged coumarin derivatives were synthesized and tested for in-vitro antiproliferative activity on human breast cancer cell lines, with some compounds showing moderate to good activity.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Management
Manu Sharma, Sudhanshu Joshi, Sunil Luthra, Anil Kumar
Summary: This study explores the contribution of Blockchain Technology in managing disruptions caused by COVID-19 and supporting resilient Food Supply Chains. Using a combination of FAHP and WASPAS, the study evaluates factors related to sourcing, lean, workforce, and flexibility, as well as the effectiveness of BC-T enabled resilient strategies in mitigating disruptions during the pandemic. The findings suggest that 'sourcing related' is the most significant disruptive factor in FSCs, and 'flexibility resilient strategy' is the most relevant strategy for BC-T enabled FSCs.
OPERATIONS MANAGEMENT RESEARCH
(2022)
Article
Economics
Sunil Luthra, Manu Sharma, Anil Kumar, Sudhanshu Joshi, Eva Collins, Sachin Mangla
Summary: Economies are transitioning to a circular model to address global issues, and cross-sector collaboration is an effective means to integrate sustainable practices into the value chain. However, the influence of cross-sector collaboration on circular supply chain management is still unexplored, and the barriers and strategies to overcome these barriers need further research.
TRANSPORTATION RESEARCH PART E-LOGISTICS AND TRANSPORTATION REVIEW
(2022)
Article
Metallurgy & Metallurgical Engineering
Suhas Sreekanth, Kjell Hurtig, Shrikant Joshi, Joel Andersson
Summary: This article provides a detailed study on the solution treatments and delta precipitation treatments carried out on laser-directed energy deposited alloy 718 specimens. The research shows that the process parameters greatly influence the delta precipitation, with different microstructural features observed under high and low energy conditions. The morphology and location of the delta phase precipitates studied in this research are crucial for designing the performance of alloy 718 built by DED process.
WELDING IN THE WORLD
(2022)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Rashmi Prava Das, Kamalakanta Muduli, Rakesh Raut, B. E. Narkhede, Himanshu Shee, Abhishek Misra
Summary: This study identifies critical factors to enhance the effectiveness of humanitarian activities during the COVID-19 pandemic. Building a blockchain-enabled digital network and using digital platforms for real-time information sharing are found to be the most significant factors.
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)