A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes

COVID-19 and the human innate immune system

(2021) Joachim L. Schultze et al.   CELL

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

(2021) Xianwen Ren et al.   CELL

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

(2021) Min Zheng et al.   NATURE IMMUNOLOGY

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores

(2020) Giovanni Targher et al.   GUT

LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

(2020) Yuki Tanaka et al.   GUT

Younger patients with MAFLD are at increased risk of severe COVID-19 illness: A multicenter preliminary analysis

(2020) Yu-Jie Zhou et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study

(2020) Dong Ji et al.   JOURNAL OF HEPATOLOGY

DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex

(2020) Vishal Nanavaty et al.   MOLECULAR CELL

Macrophages in metabolic associated fatty liver disease

(2020) Jawaher Alharthi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic‐associated fatty liver disease is associated with severity of COVID‐19

(2020) Yu‐Jie Zhou et al.   LIVER INTERNATIONAL

Exploring and visualizing large-scale genetic associations by using PheWeb

(2020) Sarah A. Gagliano Taliun et al.   NATURE GENETICS

The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease

(2020) Ali Bayoumi et al.   TRENDS IN GENETICS

Genetic insight into COVID‐19 related liver injury: A note on MBOAT7

(2020) Antonia Machill et al.   LIVER INTERNATIONAL

Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies

(2020) Carmelo Luci et al.   Frontiers in Endocrinology

Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

(2019) Jessica Maiers et al.   SEMINARS IN LIVER DISEASE

MBOAT7 is anchored to endomembranes by six transmembrane domains

(2019) Andrea Caddeo et al.   JOURNAL OF STRUCTURAL BIOLOGY

Genetic Insights for Drug Development in NAFLD

(2019) Mohammed Eslam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

(2018) Xingli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

(2017) P. Dongiovanni et al.   JOURNAL OF INTERNAL MEDICINE

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice

(2016) Kouichi Miura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis

(2016) Yongping Zhang et al.   MOLECULAR CELL

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress signaling to chromatin in health and disease

(2016) Sarah Kreuz et al.   Epigenomics

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

(2016) Khaled Thabet et al.   Nature Communications

Hepatic TLR4 signaling in obese NAFLD

(2015) Torfay Sharifnia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Mitochondrial phospholipids: role in mitochondrial function

(2015) Edgard M. Mejia et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice

(2015) J Chu et al.   MOLECULAR PSYCHIATRY

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases

(2014) Alexander J.S. Choi et al.   MOLECULES AND CELLS

Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells

(2014) Simona Zarini et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective

(2013) Ishwarlal Jialal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology

(2013) K A Shirey et al.   Mucosal Immunology

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms

(2012) Yi-Tzu Lin et al.   CURRENT GENOMICS

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

BATF–JUN is critical for IRF4-mediated transcription in T cells

(2012) Peng Li et al.   NATURE

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of macrophage polarization and function

(2012) Lionel B. Ivashkiv   TRENDS IN IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease

(2008) Maik Hüttemann et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

(2008) Miguel A. Gijón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium

(2008) Prerna Rastogi et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY