Journal
CURRENT GENOMICS
Volume 13, Issue 8, Pages 633-645Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920212803759712
Keywords
Atherosclerosis; Genetic association studies; Inflammation; Innate immunity; Single nucleotide polymorphisms; Toll-like receptors
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Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.
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