Oxidative stress signaling to chromatin in health and disease

Dynamic monitoring of oxidative DNA double-strand break and repair in cardiomyocytes

(2016) Bo Ye et al.   CARDIOVASCULAR PATHOLOGY

Oxidative stress, redox regulation and diseases of cellular differentiation

(2015) Zhi-Wei Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PIP4K and the role of nuclear phosphoinositides in tumour suppression

(2015) Roberta Fiume et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

LINE-1 hypomethylation induced by reactive oxygen species is mediated via depletion of S-adenosylmethionine

(2015) Chiraphat Kloypan et al.   CELL BIOCHEMISTRY AND FUNCTION

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

The role of antioxidants in the chemistry of oxidative stress: A review

(2015) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Posttranslational modification of Sirt6 activity by peroxynitrite

(2015) Shuqun Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress alters global histone modification and DNA methylation

(2015) Yingmei Niu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation is essential for α-synuclein-induced cell death

(2015) Plamena R. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

The Basal Transcription Complex Component TAF3 Transduces Changes in Nuclear Phosphoinositides into Transcriptional Output

(2015) Yvette Stijf-Bultsma et al.   MOLECULAR CELL

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

3-Deoxyglucosone: A Potential Glycating Agent Accountable for Structural Alteration in H3 Histone Protein through Generation of Different AGEs

(2015) Jalaluddin M. Ashraf et al.   PLoS One

Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress

(2015) Yong-Juan Xin et al.   Scientific Reports

Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer

(2015) Andreas Leodolter et al.   Clinical and Translational Gastroenterology

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

Oxidants Induce a Corticosteroid-Insensitive Phosphorylation of Histone 3 at Serine 10 in Monocytes

(2015) John A. Marwick et al.   PLoS One

Glycation of H1 Histone by 3-Deoxyglucosone: Effects on Protein Structure and Generation of Different Advanced Glycation End Products

(2015) Jalaluddin Mohammad Ashraf et al.   PLoS One

Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress

(2015) Benjamin Delatte et al.   Scientific Reports

Nuclear lactate dehydrogenase modulates histone modification in human hepatocytes

(2014) Zachary Castonguay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Balancing oxidative protein folding: The influences of reducing pathways on disulfide bond formation

(2014) Kerstin Kojer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Methylglyoxal mediated conformational changes in histone H2A—generation of carboxyethylated advanced glycation end products

(2014) Abdul Rouf Mir et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Physicochemical analysis of structural alteration and advanced glycation end products generation during glycation of H2A histone by 3-deoxyglucosone

(2014) Jalaluddin M. Ashraf et al.   IUBMB LIFE

Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks

(2014) T. Katsube et al.   JOURNAL OF BIOCHEMISTRY

A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress

(2014) Di Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

8-Oxoguanine DNA Glycosylase-1 Augments Proinflammatory Gene Expression by Facilitating the Recruitment of Site-Specific Transcription Factors

(2014) X. Ba et al.   JOURNAL OF IMMUNOLOGY

Stable Histone Adduction by 4-Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics

(2014) James J. Galligan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accessibility of Different Histone H3-Binding Domains of UHRF1 Is Allosterically Regulated by Phosphatidylinositol 5-Phosphate

(2014) Kathy A. Gelato et al.   MOLECULAR CELL

Oxidative Stress Diverts tRNA Synthetase to Nucleus for Protection against DNA Damage

(2014) Na Wei et al.   MOLECULAR CELL

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1

(2014) Eva Polanská et al.   PLoS One

Chronic Oxidative Stress Increases Growth and Tumorigenic Potential of MCF-7 Breast Cancer Cells

(2014) Prathap Kumar S. Mahalingaiah et al.   PLoS One

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure

(2013) José Luis García-Giménez et al.   ANTIOXIDANTS & REDOX SIGNALING

Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate

(2013) Kevin M. Dickson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A mechanistic overview of TET-mediated 5-methylcytosine oxidation

(2013) V.K. Chaithanya Ponnaluri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

(2013) Huajun Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Studies on peroxynitrite-modified H1 histone: Implications in systemic lupus erythematosus

(2013) M. Asad Khan et al.   BIOCHIMIE

Peroxisomal metabolism and oxidative stress

(2013) Marcus Nordgren et al.   BIOCHIMIE

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function

(2013) M. R. Heideman et al.   BLOOD

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

(2013) O. M. Dovey et al.   BLOOD

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

(2013) F. Santoro et al.   BLOOD

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

4-Hydroxy-2-nonenal modified histone-H2A: A possible antigenic stimulus for systemic lupus erythematosus autoantibodies

(2013) Abdullateef A. Alzolibani et al.   CELLULAR IMMUNOLOGY

New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension

(2013) Raquel Hernanz et al.   CLINICAL SCIENCE

Antibodies against 4-Hydroxy-2-nonenal Modified Epitopes Recognized Chromatin and Its Oxidized Forms: Role of Chromatin, Oxidized Forms of Chromatin and 4-Hydroxy-2-nonenal Modified Epitopes in the Etiopathogenesis of SLE

(2013) Hani A. Al-Shobaili et al.   DISEASE MARKERS

Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression

(2013) Sabry M. Attia et al.   FOOD AND CHEMICAL TOXICOLOGY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitric Oxide Modifies Global Histone Methylation by Inhibiting Jumonji C Domain-containing Demethylases

(2013) Jason R. Hickok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Causes and Consequences of CysteineS-Glutathionylation

(2013) Christina L. Grek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methionine Adenosyltransferase II-dependent Histone H3K9 Methylation at theCOX-2Gene Locus

(2013) Yohei Kera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cigarette Smoke Component Acrolein Modulates Chromatin Assembly by Inhibiting Histone Acetylation

(2013) Danqi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Emerging roles for chromatin as a signal integration and storage platform

(2013) Aimee I. Badeaux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress in the pathology and treatment of systemic lupus erythematosus

(2013) Andras Perl   Nature Reviews Rheumatology

Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

(2013) D. Montero et al.   Obesity Reviews

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

(2013) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage

(2013) Dennis J. Bua et al.   Scientific Reports

Human Genome Replication Proceeds through Four Chromatin States

(2013) Hanna Julienne et al.   PLoS Computational Biology

NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers

(2012) Yewei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

(2012) Sonia Martínez-Revelles et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

(2012) Norma Frizzell et al.   BIOCHEMICAL JOURNAL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription

(2012) David W. Clark et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of the epigenetic landscape in Cancer: A role for metabolic reprogramming in remodeling the epigenome

(2012) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Histone H1 Structural Changes and its Interaction with DNA in the Presence of High Glucose ConcentrationIn VivoandIn Vitro

(2012) Rahman Rahmanpour et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of advanced glycation end products in hypertension and cardiovascular risk: human studies

(2012) Marcus Baumann   Journal of the American Society of Hypertension

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1

(2012) Min-Woo Jeong et al.   MOLECULAR BIOLOGY OF THE CELL

Complexities of occupancy and sequence

(2012) Mary Muers   NATURE REVIEWS GENETICS

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

(2012) Marcelo Farina et al.   NEUROCHEMISTRY INTERNATIONAL

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Treatment of doxorubicin-resistant MCF7/Dx cells with nitric oxide causes histone glutathionylation and reversal of drug resistance

(2011) Anastasia de Luca et al.   BIOCHEMICAL JOURNAL

Molecular and biochemical characterization of nitric oxide synthase isoforms and their intracellular distribution in human peripheral blood mononuclear cells

(2011) Rohit Saluja et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification

(2011) Zhe Hou et al.   CARCINOGENESIS

Cytometric detection of chromatin relaxation, an early reporter of DNA damage response

(2011) H. Dorota Halicka et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

(2011) Kristofer S. Fritz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes

(2011) Patrick M Lombardi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

KAP1 Protein: An Enigmatic Master Regulator of the Genome

(2011) Sushma Iyengar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Peek into the Complex Realm of Histone Phosphorylation

(2011) T. Banerjee et al.   MOLECULAR AND CELLULAR BIOLOGY

Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection

(2011) Laia Bosch-Presegué et al.   MOLECULAR CELL

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code

(2011) C. Bronner   Science Signaling

Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering

(2011) Katerina Stamati et al.   Journal of Tissue Engineering

Redox Control Systems in the Nucleus: Mechanisms and Functions

(2010) Young-Mi Go et al.   ANTIOXIDANTS & REDOX SIGNALING

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nitric oxide and reactive oxygen species in the nucleus revisitedThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Chantale Provost et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells

(2010) W. Gehrmann et al.   DIABETES OBESITY & METABOLISM

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Unphosphorylated STAT and heterochromatin protect genome stability

(2010) Shian-Jang Yan et al.   FASEB JOURNAL

Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter

(2010) Ji Young Min et al.   FEBS LETTERS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isoform-specific Intermolecular Disulfide Bond Formation of Heterochromatin Protein 1 (HP1)

(2010) Shuichiro Higo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology

(2010) Bradford G. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Signaling, Alkylation (Carbonylation) of Conserved Cysteines Inactivates Class I Histone Deacetylases 1, 2, and 3 and Antagonizes Their Transcriptional Repressor Function

(2010) Kelly Doyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

GAPDH mediates nitrosylation of nuclear proteins

(2010) Michael D. Kornberg et al.   NATURE CELL BIOLOGY

Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

(2010) Nadia C Whitelaw et al.   GENOME BIOLOGY

Receptor Activation of NADPH Oxidases

(2009) Andreas Petry et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions

(2009) Na Rae Hwang et al.   BIOCHEMICAL JOURNAL

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physicochemical studies on peroxynitrite-modified H3 histone

(2009) Kiran Dixit et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice

(2009) F.E. Harrison et al.   NUTRITIONAL NEUROSCIENCE

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCɛ signaling axis in pulmonary artery smooth muscle cells

(2008) R RATHORE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

(2008) Alexi Nott et al.   NATURE

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

(2008) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox characteristics of the eukaryotic cytosol

(2007) H. Reynaldo López-Mirabal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH