Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies

Towards genetic prediction of non-alcoholic fatty liver disease trajectories: PNPLA3 and beyond

(2020) Marcin Krawczyk et al.   GASTROENTEROLOGY

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model

(2020) Mohamed Elbadawy et al.   BIOMATERIALS

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

(2020) Sandra Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Macrophage Subsets in Obesity, Aligning the Liver and Adipose Tissue

(2020) Anneleen Remmerie et al.   Frontiers in Endocrinology

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

(2020) Muhammad Nadzim Bin Ramli et al.   GASTROENTEROLOGY

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis

(2020) Guillaume Lassailly et al.   GASTROENTEROLOGY

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

(2020) Sophie Tran et al.   IMMUNITY

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

(2020) Anneleen Remmerie et al.   IMMUNITY

The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

(2019) Jingjing Cai et al.   HEPATOLOGY

Inflammatory pathways in alcoholic steatohepatitis

(2019) Bin Gao et al.   JOURNAL OF HEPATOLOGY

Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

(2019) Oliver Krenkel et al.   GUT

Liver organoids: from basic research to therapeutic applications

(2019) Nicole Prior et al.   GUT

The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis

(2019) Alkistis-Maria Papatheodoridi et al.   HEPATOLOGY

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis

(2019) Arnaud Sans et al.   Scientific Reports

Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease

(2019) Carmelo Luci et al.   Frontiers in Immunology

Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease

(2019) Natalie Stiglund et al.   Frontiers in Immunology

The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

(2019) Antonia O. Cuff et al.   Frontiers in Immunology

Gut Dysfunction and Non-alcoholic Fatty Liver Disease

(2019) Felix Grabherr et al.   Frontiers in Endocrinology

Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism

(2019) Jin Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Adaptive immunity: an emerging player in the progression of NAFLD

(2019) Salvatore Sutti et al.   Nature Reviews Gastroenterology & Hepatology

Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis

(2019) Neeta B. Amin et al.   Science Translational Medicine

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

(2019) Naga Chalasani et al.   GASTROENTEROLOGY

Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension

(2019) Guadalupe Garcia-Tsao et al.   JOURNAL OF HEPATOLOGY

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Hepatic NK cells attenuate fibrosis progression of non‐alcoholic steatohepatitis in dependent of CXCL10‐mediated recruitment

(2019) Yuting Fan et al.   LIVER INTERNATIONAL

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease

(2018) Richard Parker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Non-alcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates

(2018) Zobair Younossi et al.   Clinical Gastroenterology and Hepatology

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

(2018) Samar H Ibrahim et al.   GUT

Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis

(2018) Dirk J. van der Windt et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Effects of treatment with Maraviroc a CCR5 inhibitor on a human hepatic stellate cell line

(2018) Nicola Coppola et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

An update on the recent advances in antifibrotic therapy

(2018) Frank Tacke et al.   Expert Review of Gastroenterology & Hepatology

Complete Resolution of Nonalcoholic Fatty Liver Disease After Bariatric Surgery: A Systematic Review and Meta-Analysis

(2018) Yung Lee et al.   Clinical Gastroenterology and Hepatology

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

(2018) Xavier Michelet et al.   NATURE IMMUNOLOGY

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Innate lymphoid cell sensing of tissue vitality

(2018) Alexander David Barrow et al.   CURRENT OPINION IN IMMUNOLOGY

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

(2017) Selma Boulenouar et al.   IMMUNITY

CD44 is a key player in non-alcoholic steatohepatitis

(2017) Stéphanie Patouraux et al.   JOURNAL OF HEPATOLOGY

Treatment of NAFLD with diet, physical activity and exercise

(2017) Manuel Romero-Gómez et al.   JOURNAL OF HEPATOLOGY

Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness

(2017) Yong-ho Lee et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

(2017) Guang-Nian Zhao et al.   NATURE MEDICINE

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Non-alcoholic fatty liver disease and risk of type 2 diabetes

(2016) S. Lallukka et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

(2016) Yuneivy Cepero-Donates et al.   CYTOKINE

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

(2016) Giulio Marchesini et al.   HEPATOLOGY

Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis

(2016) Benjamin Lelouvier et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

NKp46+ natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice

(2016) Annie-Carole Tosello-Trampont et al.   HEPATOLOGY

Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance

(2016) Timothy E. O’Sullivan et al.   IMMUNITY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Innate lymphoid cells as novel regulators of obesity and its-associated metabolic dysfunction

(2016) D. Yang et al.   Obesity Reviews

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Roux-En Y Gastric Bypass Results in Long-Term Remission of Hepatocyte Apoptosis and Hepatic Histological Features of Non-alcoholic Steatohepatitis

(2016) Anne-Sophie Schneck et al.   Frontiers in Physiology

Natural Killer Cells and Liver Fibrosis

(2016) Frank Fasbender et al.   Frontiers in Immunology

Myeloperoxidase–Hepatocyte–Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis

(2015) Benjamin Pulli et al.   ANTIOXIDANTS & REDOX SIGNALING

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Effect of Weight Loss on Magnetic Resonance Imaging Estimation of Liver Fat and Volume in Patients With Nonalcoholic Steatohepatitis

(2015) Niraj S. Patel et al.   Clinical Gastroenterology and Hepatology

Safety and efficacy of lobeglitazone monotherapy in patients with type 2 diabetes mellitus over 52 weeks: An open-label extension study

(2015) Sun Hwa Kim et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Arginase 2 deficiency results in spontaneous steatohepatitis: A novel link between innate immune activation and hepatic de novo lipogenesis

(2015) Laura A. Navarro et al.   JOURNAL OF HEPATOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ

(2014) Xiujing Feng et al.   BIOCHEMICAL PHARMACOLOGY

Anti-CD44 Antibody Treatment Lowers Hyperglycemia and Improves Insulin Resistance, Adipose Inflammation, and Hepatic Steatosis in Diet-Induced Obese Mice

(2014) Keiichi Kodama et al.   DIABETES

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

(2014) Hidetaka Morinaga et al.   DIABETES

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Biomarkers of liver cell death

(2014) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

(2014) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity

(2014) Robert W. O'Rourke et al.   Obesity

Efficacy and Safety of Lobeglitazone Monotherapy in Patients with Type 2 Diabetes Mellitus over 24-Weeks: A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo Controlled Trial

(2014) Sin Gon Kim et al.   PLoS One

FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

(2014) Jun Yao   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy and Non-Alcoholic Fatty Liver Disease

(2014) Vanessa J. Lavallard et al.   Biomed Research International

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis

(2013) Ju Dong Yang et al.   HEPATOLOGY

Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease

(2013) Rachel H. McMahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet

(2013) Rie Ibusuki et al.   LIVER INTERNATIONAL

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Pioglitazone prescription increases risk of bladder cancer in patients with type 2 diabetes: an updated meta-analysis

(2013) Shiyao He et al.   TUMOR BIOLOGY

Non-alcoholic steatohepatitis in morbidly obese patients

(2013) Albert Tran et al.   Clinics and Research in Hepatology and Gastroenterology

Regulation of Mouse NK Cell Development and Function by Cytokines

(2013) Antoine Marçais et al.   Frontiers in Immunology

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from the Rotterdam study

(2012) Edith M. Koehler et al.   JOURNAL OF HEPATOLOGY

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice

(2012) Robert W. O'Rourke et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

(2012) Sander S. Rensen et al.   PLoS One

Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis

(2011) E. Boettcher et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients

(2010) R. Anty et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Trunk Fat Is Associated With Increased Serum Levels of Alanine Aminotransferase in the United States

(2010) Constance E. Ruhl et al.   GASTROENTEROLOGY

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

(2010) Marie-Luise Berres et al.   JOURNAL OF CLINICAL INVESTIGATION

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients

(2010) Adeline Bertola et al.   PLoS One

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

CCR1 and CCR5 promote hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   JOURNAL OF CLINICAL INVESTIGATION

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism