FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM

Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches

(2022) Mohammad Sheibani et al.   Cardiovascular Toxicology

Protective effects of necrostatin-1 on doxorubicin-induced cardiotoxicity in rat heart

(2022) Zeynep Erdogmus Ozgen et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

(2022) Yasmine Messaoud-Nacer et al.   Cell Death & Disease

PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study

(2022) Felicitas J. Detmer et al.   Scientific Reports

FUN14 Domain Containing 1 (FUNDC1): A Promising Mitophagy Receptor Regulating Mitochondrial Homeostasis in Cardiovascular Diseases

(2022) Yu Mao et al.   Frontiers in Pharmacology

Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol

(2022) Wei Yu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Intravenous Nicotinamide Riboside Administration Has a Cardioprotective Effect in Chronic Doxorubicin-Induced Cardiomyopathy

(2022) Ekaterina Podyacheva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Empagliflozin activates Wnt/β-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome

(2022) Chen Cai et al.   Molecular Metabolism

MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats

(2022) Rafael Sánchez-Sánchez et al.   Antioxidants

Regulated cell death pathways in doxorubicin-induced cardiotoxicity

(2021) Effimia Christidi et al.   Cell Death & Disease

FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis

(2021) Cheng Wang et al.   Nature Communications

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

(2021) Zhaohui Pei et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro

(2021) Chun Wang et al.   TOXICOLOGY

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

Periplocymarin Alleviates Doxorubicin-Induced Heart Failure and Excessive Accumulation of Ceramides

(2021) Weijing Yun et al.   Frontiers in Cardiovascular Medicine

The role of FUNDC1 in mitophagy, mitochondrial dynamics and human diseases

(2021) Hui Liu et al.   BIOCHEMICAL PHARMACOLOGY

Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy

(2020) Haixia Xu et al.   Frontiers in Physiology

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Min Zheng et al.   IMMUNOLOGICAL REVIEWS

Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission

(2020) Xinyue Liang et al.   PHARMACOLOGICAL RESEARCH

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

(2020) Jie Li et al.   Science Signaling

Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

(2020) Wenjia Li et al.   Cell Death & Disease

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Parimal Samir et al.   Frontiers in Cellular and Infection Microbiology

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

New insights into the activities and toxicities of the old anticancer drug doxorubicin

(2020) Sabina Y. van der Zanden et al.   FEBS Journal

FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity

(2020) Jun Ren et al.   Science Advances

Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner

(2020) Wei Yu et al.   Cardiovascular Diagnosis and Therapy

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of Mitophagy Receptor FUNDC1 Impairs Mitochondrial Quality and Aggravates Dietary-Induced Obesity and Metabolic Syndrome

(2019) Hao Wu et al.   Autophagy

Inhibition of miR-23a attenuates doxorubicin-induced mitochondria-dependent cardiomyocyte apoptosis by targeting the PGC-1α/Drp1 pathway

(2019) Jingjing Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy

(2019) Michael P. Catanzaro et al.   FASEB JOURNAL

Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism

(2019) Wenqian Cai et al.   Cell Death & Disease

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy

(2019) Rimpy Dhingra et al.   CARDIOVASCULAR RESEARCH

miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity

(2019) Jian-An Pan et al.   Cell Death & Disease

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth

(2018) Mingchuan Li et al.   CIRCULATION

Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy

(2018) Shuyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis

(2018) Dong Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation

(2018) Wenhui Li et al.   HEPATOLOGY

Cyclic stretch increases mitochondrial biogenesis in a cardiac cell line

(2018) Hyoung Kyu Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism

(2016) Wei Ge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TUFM downregulation induces epithelial–mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3β signaling

(2016) Kai He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage

(2015) J. Liu et al.   NUCLEIC ACIDS RESEARCH

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

(2014) Rimpy Dhingra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy

(2013) Yingmei Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE