A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies
Authors
Keywords
-
Journal
mBio
Volume -, Issue -, Pages -
Publisher
American Society for Microbiology
Online
2023-01-11
DOI
10.1128/mbio.03370-22
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer
- (2022) Zhi Yang et al. Nature Communications
- Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys
- (2022) Amarendra Pegu et al. Cell Reports
- Structural Dynamics Reveal Isolate-specific Differences at Neutralization Epitopes on HIV Env
- (2022) Edgar A. Hodge et al. iScience
- Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers
- (2022) Zhi Yang et al. JOURNAL OF VIROLOGY
- Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles
- (2021) Néstor Vázquez Bernat et al. IMMUNITY
- New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure
- (2021) Hui Li et al. JOURNAL OF VIROLOGY
- Immune responses and viral persistence in SHIV.C.CH848-infected rhesus macaques
- (2021) Widade Ziani et al. JOURNAL OF VIROLOGY
- Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles
- (2021) Philip J. M. Brouwer et al. npj Vaccines
- Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env
- (2021) Amelia Escolano et al. Science Translational Medicine
- Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization
- (2020) Qifeng Han et al. Cell Reports
- T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers
- (2020) Prabhu S. Arunachalam et al. NATURE MEDICINE
- Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models
- (2020) Ming Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition
- (2020) Jason Gorman et al. Cell Reports
- Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
- (2020) Ryan S. Roark et al. SCIENCE
- HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design
- (2019) Christine A. Bricault et al. Cell Host & Microbe
- SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes
- (2019) Ashley N. Nelson et al. JOURNAL OF VIROLOGY
- The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template
- (2019) Raiees Andrabi et al. Cell Reports
- Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization
- (2019) Rui Kong et al. CELL
- SHIV.CH505 infection of rhesus macaques results in persistent viral replication and induces intestinal immunopathology
- (2019) Katharine J. Bar et al. JOURNAL OF VIROLOGY
- Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
- (2019) Qifeng Han et al. Nature Communications
- Coevolution of HIV-1 and broadly neutralizing antibodies
- (2019) Nicole A. Doria-Rose et al. Current Opinion in HIV and AIDS
- A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge
- (2019) Amarendra Pegu et al. Cell Host & Microbe
- A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
- (2019) Jon M. Steichen et al. SCIENCE
- Strategies for a multi-stage neutralizing antibody-based HIV vaccine
- (2018) Raiees Andrabi et al. CURRENT OPINION IN IMMUNOLOGY
- HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure
- (2018) Peter D. Kwong et al. IMMUNITY
- Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design
- (2018) Kimmo Rantalainen et al. Cell Reports
- HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations
- (2018) Xiaochu Ma et al. eLife
- Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
- (2018) Elise Landais et al. Retrovirology
- Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers
- (2018) Matthias G. Pauthner et al. IMMUNITY
- Recent progress in broadly neutralizing antibodies to HIV
- (2018) Devin Sok et al. NATURE IMMUNOLOGY
- Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions
- (2018) Constantinos Kurt Wibmer et al. Nature Communications
- Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth
- (2018) Kshitij Wagh et al. Cell Reports
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development
- (2017) Raiees Andrabi et al. IMMUNITY
- A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
- (2017) Jeong Hyun Lee et al. IMMUNITY
- HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
- (2017) Elise Landais et al. IMMUNITY
- Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop
- (2017) Evan M. Cale et al. IMMUNITY
- Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies
- (2017) Penny L. Moore et al. IMMUNOLOGICAL REVIEWS
- Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies
- (2017) Laurent Verkoczy et al. IMMUNOLOGICAL REVIEWS
- The HIV-1 envelope glycoprotein structure: nailing down a moving target
- (2017) Andrew B Ward et al. IMMUNOLOGICAL REVIEWS
- Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses
- (2017) Jérémie Prévost et al. JOURNAL OF VIROLOGY
- Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike
- (2017) Gabriel Ozorowski et al. NATURE
- Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee
- (2017) Hannah J. Barbian et al. Retrovirology
- Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
- (2017) Mattia Bonsignori et al. Science Translational Medicine
- Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
- (2017) James E. Voss et al. Cell Reports
- Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models
- (2017) Kevin O. Saunders et al. Cell Reports
- Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies
- (2017) Haoqing Wang et al. eLife
- Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies
- (2017) Akshaya Ramesh et al. Frontiers in Immunology
- Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
- (2016) Mattia Bonsignori et al. CELL
- Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop
- (2016) Haoqing Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
- (2016) Hui Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Visualizing antibody affinity maturation in germinal centers
- (2016) J. M. J. Tas et al. SCIENCE
- SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts
- (2016) Chaim A. Schramm et al. Frontiers in Immunology
- Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies
- (2015) Shenshen Wang et al. CELL
- Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design
- (2015) Raiees Andrabi et al. IMMUNITY
- A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site
- (2015) Liuzhe Li et al. MOLECULAR IMMUNOLOGY
- Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies
- (2015) Jinal N Bhiman et al. NATURE MEDICINE
- Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
- (2015) Jason Gorman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
- (2015) Young Do Kwon et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants
- (2015) Peter Hraber et al. Viruses-Basel
- Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas
- (2015) Hannah J. Barbian et al. mBio
- Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
- (2015) Jason Gorman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
- (2015) Young Do Kwon et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved
- (2014) Kevin Wiehe et al. IMMUNITY
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
- (2014) Nicole A. Doria-Rose et al. NATURE
- Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
- (2014) Devin Sok et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
- (2014) J. B. Munro et al. SCIENCE
- Systematic analysis of the in situ crosstalk of tyrosine modifications reveals no additional natural selection on multiply modified residues
- (2014) Zhicheng Pan et al. Scientific Reports
- Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
- (2013) Peter Hraber et al. AIDS
- Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2
- (2013) Hua-Xin Liao et al. IMMUNITY
- Global Panel of HIV-1 Env Reference Strains for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies
- (2013) A. deCamp et al. JOURNAL OF VIROLOGY
- Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
- (2013) Hua-Xin Liao et al. NATURE
- IgBLAST: an immunoglobulin variable domain sequence analysis tool
- (2013) Jian Ye et al. NUCLEIC ACIDS RESEARCH
- Antibodies in HIV-1 Vaccine Development and Therapy
- (2013) F. Klein et al. SCIENCE
- A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
- (2013) Rogier W. Sanders et al. PLoS Pathogens
- B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
- (2012) Barton F Haynes et al. NATURE BIOTECHNOLOGY
- Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding
- (2012) Y. Guan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
- (2011) M. Bonsignori et al. JOURNAL OF VIROLOGY
- The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
- (2011) E. S. Gray et al. JOURNAL OF VIROLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Correlates of Protection Induced by Vaccination
- (2010) S. A. Plotkin Clinical and Vaccine Immunology
- Conserved structural elements in the V3 crown of HIV-1 gp120
- (2010) Xunqing Jiang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection
- (2009) Jesus F. Salazar-Gonzalez et al. JOURNAL OF EXPERIMENTAL MEDICINE
- High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies
- (2009) Hua-Xin Liao et al. JOURNAL OF VIROLOGICAL METHODS
- Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz
- (2009) Brandon F. Keele et al. NATURE
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
- (2008) B. F. Keele et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now