Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

(2015) Pia Dosenovic et al.   CELL

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

(2015) Tongqing Zhou et al.   CELL

The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel

(2015) Ruimin Pan et al.   JOURNAL OF VIROLOGY

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

(2015) Jinal N Bhiman et al.   NATURE MEDICINE

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

(2014) Nicole A. Doria-Rose et al.   NATURE

Transplanting Supersites of HIV-1 Vulnerability

(2014) Tongqing Zhou et al.   PLoS One

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

(2014) Devin Sok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

CD4-Induced Activation in a Soluble HIV-1 Env Trimer

(2014) Miklos Guttman et al.   STRUCTURE

Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST

(2014) Bin Shi et al.   Theoretical Biology and Medical Modelling

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

(2013) Peter Hraber et al.   AIDS

Thermodynamic Signatures of the Antigen Binding Site of mAb 447–52D Targeting the Third Variable Region of HIV-1 gp120

(2013) April Killikelly et al.   BIOCHEMISTRY

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

(2013) Tongqing Zhou et al.   IMMUNITY

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

(2013) Andrew T. McGuire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

(2013) Marie Pancera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

N332-Directed Broadly Neutralizing Antibodies Use Diverse Modes of HIV-1 Recognition: Inferences from Heavy-Light Chain Complementation of Function

(2013) Marie Pancera et al.   PLoS One

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

(2013) Jean-Philippe Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

(2013) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate

(2012) Joel D. A. Tyndall et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

(2012) Peter D. Kwong et al.   IMMUNITY

Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire

(2012) Bryan S. Briney et al.   IMMUNOLOGY

A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies

(2012) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes

(2012) Bryan S. Briney et al.   PLoS One

Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120

(2012) Anthony P. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

(2011) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

(2011) X. Wu et al.   SCIENCE

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

(2010) M. Pancera et al.   JOURNAL OF VIROLOGY

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

(2010) R. Pejchal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

(2009) L. Chen et al.   SCIENCE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE