B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
Authors
Keywords
-
Journal
NATURE BIOTECHNOLOGY
Volume 30, Issue 5, Pages 423-433
Publisher
Springer Nature
Online
2012-05-08
DOI
10.1038/nbt.2197
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Rational Design of Vaccines to Elicit Broadly Neutralizing Antibodies to HIV-1
- (2013) P. D. Kwong et al. Cold Spring Harbor Perspectives in Medicine
- Membrane Protein Structure and Dynamics from NMR Spectroscopy
- (2012) Mei Hong et al. Annual Review of Physical Chemistry
- Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design
- (2012) Mattia Bonsignori et al. JOURNAL OF VIROLOGY
- Follicular Helper CD4 T Cells (TFH)
- (2011) Shane Crotty Annual Review of Immunology
- Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies
- (2011) Laurent Verkoczy et al. CURRENT OPINION IN IMMUNOLOGY
- Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy
- (2011) Nikolaus Grigorieff et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated
- (2011) Hua-Xin Liao et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center
- (2011) Tanja A. Schwickert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Rescue of HIV-1 Broad Neutralizing Antibody-Expressing B Cells in 2F5 VH x VL Knockin Mice Reveals Multiple Tolerance Controls
- (2011) L. Verkoczy et al. JOURNAL OF IMMUNOLOGY
- Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies
- (2011) Z. Zhu et al. JOURNAL OF VIROLOGY
- Differential Reactivity of Germ Line Allelic Variants of a Broadly Neutralizing HIV-1 Antibody to a gp41 Fusion Intermediate Conformation
- (2011) S. M. Alam et al. JOURNAL OF VIROLOGY
- Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
- (2011) M. Bonsignori et al. JOURNAL OF VIROLOGY
- The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
- (2011) E. S. Gray et al. JOURNAL OF VIROLOGY
- Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals
- (2011) G. D. Tomaras et al. JOURNAL OF VIROLOGY
- Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies
- (2011) D. C. Malherbe et al. JOURNAL OF VIROLOGY
- Isolation of a Monoclonal Antibody That Targets the Alpha-2 Helix of gp120 and Represents the Initial Autologous Neutralizing-Antibody Response in an HIV-1 Subtype C-Infected Individual
- (2011) E. S. Gray et al. JOURNAL OF VIROLOGY
- Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
- (2011) Jason S. McLellan et al. NATURE
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B Cell Sorting
- (2011) Lynn Morris et al. PLoS One
- H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination
- (2011) M. Anthony Moody et al. PLoS One
- Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin
- (2011) J. R. R. Whittle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells
- (2011) J. F. Scheid et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Virtual screening using molecular simulations
- (2011) Tianyi Yang et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
- (2011) X. Wu et al. SCIENCE
- Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
- (2011) M. L. Azoitei et al. SCIENCE
- Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
- (2011) R. Diskin et al. SCIENCE
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
- (2011) J. F. Scheid et al. SCIENCE
- Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
- (2011) S. J. Fleishman et al. SCIENCE
- A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
- (2011) R. Pejchal et al. SCIENCE
- Progress Toward Development of a Hepatitis C Vaccine with Broad Shoulders
- (2011) R. Ray Science Translational Medicine
- A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques
- (2011) P. Garrone et al. Science Translational Medicine
- Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies
- (2011) Ben-Jiang Ma et al. PLoS Pathogens
- Structure, mechanism, and substrate specificity of kynureninase
- (2010) Robert S. Phillips BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
- (2010) Gabriel D. Victora et al. CELL
- Correlates of Protection Induced by Vaccination
- (2010) S. A. Plotkin Clinical and Vaccine Immunology
- Human peripheral blood B-cell compartments: A crossroad in B-cell traffic
- (2010) M. Perez-Andres et al. CYTOMETRY PART B-CLINICAL CYTOMETRY
- Atomic model of an infectious rotavirus particle
- (2010) Ethan C Settembre et al. EMBO JOURNAL
- Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination
- (2010) M. Juliana McElrath et al. IMMUNITY
- Reverse Vaccinology: Developing Vaccines in the Era of Genomics
- (2010) Alessandro Sette et al. IMMUNITY
- Promising General Solution to the Problem of Ligating Peptides and Glycopeptides
- (2010) Ping Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1
- (2010) A. Changela et al. JOURNAL OF VIROLOGY
- Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1
- (2010) M. Pancera et al. JOURNAL OF VIROLOGY
- Therapeutic antibodies, vaccines and antibodyomes
- (2010) Dimiter S. Dimitrov mAbs
- Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
- (2010) Hugo Mouquet et al. NATURE
- Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
- (2010) Davide Corti et al. PLoS One
- Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution
- (2010) X. Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Elicitation of structure-specific antibodies by epitope scaffolds
- (2010) G. Ofek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli
- (2010) D. G. Moriel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
- (2010) X. Wu et al. SCIENCE
- B cell responses to HIV-1 infection and vaccination: pathways to preventing infection
- (2010) Barton F. Haynes et al. TRENDS IN MOLECULAR MEDICINE
- Is developing an HIV-1 vaccine possible?
- (2010) Barton F Haynes et al. Current Opinion in HIV and AIDS
- Optimality of Mutation and Selection in Germinal Centers
- (2010) Jingshan Zhang et al. PLoS Computational Biology
- A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals
- (2010) Laura M. Walker et al. PLoS Pathogens
- Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens
- (2009) Xiaodong Xiao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Vaccines: the Fourth Century
- (2009) S. A. Plotkin Clinical and Vaccine Immunology
- The use of genomics in microbial vaccine development
- (2009) Stefania Bambini et al. DRUG DISCOVERY TODAY
- Original Antigenic Sin Responses to Influenza Viruses
- (2009) J. H. Kim et al. JOURNAL OF IMMUNOLOGY
- HIV-1 Envelope Induces Memory B Cell Responses That Correlate with Plasma Antibody Levels after Envelope gp120 Protein Vaccination or HIV-1 Infection
- (2009) M. Bonsignori et al. JOURNAL OF IMMUNOLOGY
- Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys29−Gly77Glycopeptide Domain
- (2009) Yu Yuan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies
- (2009) Hua-Xin Liao et al. JOURNAL OF VIROLOGICAL METHODS
- Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
- (2009) A. J. Hessell et al. JOURNAL OF VIROLOGY
- Exploring peptide mimics for the production of antibodies against discontinuous protein epitopes
- (2009) Melita B. Irving et al. MOLECULAR IMMUNOLOGY
- Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
- (2009) Johannes F. Scheid et al. NATURE
- Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
- (2009) Ann J Hessell et al. NATURE MEDICINE
- Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
- (2009) Jianhua Sui et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Role of HIV membrane in neutralization by two broadly neutralizing antibodies
- (2009) S. M. Alam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
- (2009) L. Verkoczy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibody Recognition of a Highly Conserved Influenza Virus Epitope
- (2009) D. C. Ekiert et al. SCIENCE
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies
- (2009) Xiaodong Xiao et al. Viruses-Basel
- Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers
- (2009) Ann J. Hessell et al. PLoS Pathogens
- Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine
- (2008) Robert Thimme et al. BIOLOGICAL CHEMISTRY
- Vaccines: Correlates of Vaccine‐Induced Immunity
- (2008) Stanley A. Plotkin CLINICAL INFECTIOUS DISEASES
- Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
- (2008) G. D. Tomaras et al. JOURNAL OF VIROLOGY
- Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
- (2008) Jens Wrammert et al. NATURE
- The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
- (2008) Gunilla B. Karlsson Hedestam et al. NATURE REVIEWS MICROBIOLOGY
- Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells
- (2008) Mark Throsby et al. PLoS One
- Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors
- (2008) B. Mietzner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
- (2008) G. Frey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies
- (2008) A. K. Kashyap et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toward an AIDS Vaccine
- (2008) B. D. Walker et al. SCIENCE
- Structure-based antigen design: a strategy for next generation vaccines
- (2008) Philip R. Dormitzer et al. TRENDS IN BIOTECHNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started