DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

(2022) Haneul Yoo et al.   MOLECULAR CELL

Chromatoid Bodies in the Regulation of Spermatogenesis: Novel Role of GRTH

(2022) Rajakumar Anbazhagan et al.   Cells

The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA–Protein Condensates

(2022) Karsten Weis et al.   Annual Review of Biochemistry

Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation

(2022) Hui Shen et al.   MOLECULAR CELL

Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity

(2022) Miriam Linsenmeier et al.   Nature Communications

DEAD box 1 (DDX1) protein binds to and protects cytoplasmic stress response mRNAs in cells exposed to oxidative stress

(2022) Lei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation

(2021) Nicolette P. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin

(2021) Eunji Kim et al.   BIOCHEMICAL JOURNAL

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

(2021) Brian D. Freibaum et al.   JOURNAL OF CELL BIOLOGY

DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization

(2021) Blagovesta Popova et al.   PLoS Genetics

Dead or alive: DEAD-box ATPases as regulators of ribonucleoprotein complex condensation

(2021) Karsten Weis   BIOLOGICAL CHEMISTRY

The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells

(2021) Michael Pryszlak et al.   Cell Reports

lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription

(2021) Man Wu et al.   SCIENCE

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

(2021) Dimitris C. Kanellis et al.   Science Advances

Building RNA-protein germ granules: insights from the multifaceted functions of DEAD-box helicase Vasa/Ddx4 in germline development

(2021) Caoling Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The mRNA decapping complex is buffered by nuclear localization

(2021) Kiril Tishinov et al.   JOURNAL OF CELL SCIENCE

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Differential roles of two DDX17 isoforms in the formation of membraneless organelles

(2020) Yuya Hirai et al.   JOURNAL OF BIOCHEMISTRY

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

(2020) Carmen Pérez-Calero et al.   GENES & DEVELOPMENT

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior

(2020) Benjamin S. Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and Regulation of RNA Condensation in RNP Granule Formation

(2020) Devin Tauber et al.   TRENDS IN BIOCHEMICAL SCIENCES

An In Vitro Assembly System Identifies Roles for RNA Nucleation and ATP in Yeast Stress Granule Formation

(2020) Kyle Begovich et al.   MOLECULAR CELL

Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder

(2020) Lovisa Stenström et al.   Molecular Systems Biology

A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

(2020) Wenmin Xing et al.   eLife

Uncoupling of nucleo-cytoplasmic RNA export and localization during stress

(2019) Hodaya Hochberg-Laufer et al.   NUCLEIC ACIDS RESEARCH

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

The DEAD-box RNA helicase Ded1 has a role in the translational response to TORC1 inhibition

(2019) Peyman P. Aryanpur et al.   MOLECULAR BIOLOGY OF THE CELL

Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout

(2019) Matthew R. Hildebrandt et al.   DEVELOPMENTAL BIOLOGY

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

(2019) Dae-Seok Kim et al.   MOLECULAR CELL

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182

(2019) Nishi R Sharma et al.   NUCLEIC ACIDS RESEARCH

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis

(2019) Bruno Di Stefano et al.   Cell Stem Cell

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

(2019) David T. McSwiggen et al.   GENES & DEVELOPMENT

Probing and engineering liquid-phase organelles

(2019) Dan Bracha et al.   NATURE BIOTECHNOLOGY

DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA

(2018) Sharad Awasthi et al.   NUCLEIC ACIDS RESEARCH

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

(2018) David S.W. Protter et al.   Cell Reports

RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes

(2018) Alexis H. Bennett et al.   PLoS Genetics

Multifunctional Protein Materials and Microreactors using Low Complexity Domains as Molecular Adhesives

(2018) Lenka Faltova et al.   ACS Nano

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

Controllable protein phase separation and modular recruitment to form responsive membraneless organelles

(2018) Benjamin S. Schuster et al.   Nature Communications

A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells

(2018) Doris Berchtold et al.   MOLECULAR CELL

Acetylation of intrinsically disordered regions regulates phase separation

(2018) Makoto Saito et al.   Nature Chemical Biology

Ribosome assembly coming into focus

(2018) Sebastian Klinge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DDX54 regulates transcriptome dynamics during DNA damage response

(2017) Miha Milek et al.   GENOME RESEARCH

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Numerous interactions act redundantly to assemble a tunable size of P bodies inSaccharomyces cerevisiae

(2017) Bhalchandra S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human protein atlas: A spatial map of the human proteome

(2017) Peter J. Thul et al.   PROTEIN SCIENCE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

The nucleolar helicase DDX56 redistributes to West Nile virus assembly sites

(2017) Colleen R. Reid et al.   VIROLOGY

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

(2017) Andrea Pawellek et al.   eLife

The role of TREX in gene expression and disease

(2016) C. G. Heath et al.   BIOCHEMICAL JOURNAL

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks

(2016) Lei Li et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP

(2016) Younghoon Kim et al.   MOLECULAR CELL

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters

(2016) Timothy J. Nott et al.   Nature Chemistry

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

(2016) Yasmine A. Valentin-Vega et al.   Scientific Reports

ATPase activity of the DEAD-box protein Dhh1 controls processing body formation

(2016) Christopher Frederick Mugler et al.   eLife

Influenza virus mRNA trafficking through host nuclear speckles

(2016) Amir Mor et al.   Nature Microbiology

Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling

(2015) Lot Snijders Blok et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DEAD-box helicase DDX27 regulates 3′ end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex

(2015) Markus Kellner et al.   EXPERIMENTAL CELL RESEARCH

The conformational plasticity of eukaryotic RNA-dependent ATPases

(2015) Sevim Ozgur et al.   FEBS Journal

Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis

(2015) Leslie B. Epling et al.   JOURNAL OF MOLECULAR BIOLOGY

Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1p

(2015) Andrea A. Putnam et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo mapping of the functional regions of the DEAD-box helicase Vasa

(2015) M. Dehghani et al.   Biology Open

RNA Helicase Proteins as Chaperones and Remodelers

(2014) Inga Jarmoskaite et al.   Annual Review of Biochemistry

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts

(2014) Jordi Xiol et al.   CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1

(2014) O. J. Pettersson et al.   NUCLEIC ACIDS RESEARCH

DEAD-box helicases as integrators of RNA, nucleotide and protein binding

(2013) Andrea A. Putnam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Translation Repressors, an RNA Helicase, and Developmental Cues Control RNP Phase Transitions during Early Development

(2013) Arnaud Hubstenberger et al.   DEVELOPMENTAL CELL

DExD/H-box RNA helicases in ribosome biogenesis

(2013) Roman Martin et al.   RNA Biology

Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability

(2013) C. Saguez et al.   RNA

DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas

(2012) T. Fukawa et al.   CANCER RESEARCH

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

The Helicase HAGE Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Cell Proliferationin Vivo

(2012) Adam J. Linley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perispeckles are major assembly sites for the exon junction core complex

(2012) Elisabeth Daguenet et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple binding of repressed mRNAs by the P-body protein Rck/p54

(2012) M. Ernoult-Lange et al.   RNA

Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response

(2011) Jing-Wen Shih et al.   BIOCHEMICAL JOURNAL

Intermolecular Interactions within the Abundant DEAD-box Protein Dhh1 Regulate Its Activityin Vivo

(2011) Arnob Dutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

(2011) François-Xavier Laurent et al.   NUCLEIC ACIDS RESEARCH

MVH in piRNA processing and gene silencing of retrotransposons

(2010) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

Mammalian DEAD Box Protein Ddx51 Acts in 3' End Maturation of 28S rRNA by Promoting the Release of U8 snoRNA

(2010) L. Srivastava et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for TREX components in the release of spliced mRNA from nuclear speckle domains

(2010) Anusha P. Dias et al.   Nature Communications

Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs

(2009) Vidya Balagopal et al.   CURRENT OPINION IN CELL BIOLOGY

Combinations of DEAD box proteins distinguish distinct types of RNA: Protein complexes in neurons

(2009) Linda C. Miller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of p54 RNA Helicase Activity and Its C-terminal Domain in Translational Repression, P-body Localization and Assembly

(2009) Nicola Minshall et al.   MOLECULAR BIOLOGY OF THE CELL

MBNL1 associates with YB-1 in cytoplasmic stress granules

(2008) Hayato Onishi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Role for DEAD Box 1 at DNA Double-Strand Breaks

(2008) L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA

(2008) Jing Ma et al.   VIROLOGY