Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation

Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development

(2020) Ashley L. Lennox et al.   NEURON

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

(2020) Suna Gulay et al.   eLife

General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation

(2020) Leo Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The DEAD-box RNA helicase Ded1 has a role in the translational response to TORC1 inhibition

(2019) Peyman P. Aryanpur et al.   MOLECULAR BIOLOGY OF THE CELL

Stress granule: a promising target for cancer treatment

(2019) Xiaomeng Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

Translational Control in Cancer

(2018) Nathaniel Robichaud et al.   Cold Spring Harbor Perspectives in Biology

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

(2018) Ulf-Peter Guenther et al.   NATURE

Phenotypic expansion in DDX3X - a common cause of intellectual disability in females

(2018) Xia Wang et al.   Annals of Clinical and Translational Neurology

Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner

(2018) Neha Gupta et al.   eLife

Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p

(2017) Deepak Sharma et al.   JOURNAL OF MOLECULAR BIOLOGY

Gle1 Regulates RNA Binding of the DEAD-Box Helicase Ded1 in Its Complex Role in Translation Initiation

(2017) Peyman P. Aryanpur et al.   MOLECULAR AND CELLULAR BIOLOGY

Eukaryotic aspects of translation initiation brought into focus

(2017) Christopher H. S. Aylett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Comparing children and adults with medulloblastoma: a SEER based analysis

(2017) Qian Li et al.   Oncotarget

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

(2016) Sekyung Oh et al.   Oncotarget

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

(2016) Yasmine A. Valentin-Vega et al.   Scientific Reports

Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling

(2015) Lot Snijders Blok et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A systematic review of neuropsychological outcomes following posterior fossa tumor surgery in children

(2015) Emily Hanzlik et al.   CHILDS NERVOUS SYSTEM

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A

(2015) Neelam Dabas Sen et al.   GENOME RESEARCH

Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3

(2015) Stephen N. Floor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis

(2015) Leslie B. Epling et al.   JOURNAL OF MOLECULAR BIOLOGY

Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

(2015) Lu Jiang et al.   NATURE GENETICS

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

The Ded1/DDX3 subfamily of DEAD-box RNA helicases

(2014) Deepak Sharma et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

(2012) Ricardo Soto-Rifo et al.   EMBO JOURNAL

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress

(2012) M. V. Gerashchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response

(2011) Jing-Wen Shih et al.   BIOCHEMICAL JOURNAL

Gle1 Is a Multifunctional DEAD-box Protein Regulator That Modulates Ded1 in Translation Initiation

(2011) Timothy A. Bolger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of mRNA Export and Translation Termination by Inositol Hexakisphosphate Requires Specific Interaction with Gle1

(2010) Abel R. Alcázar-Román et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Core neurocognitive functions in children treated for posterior fossa tumors.

(2008) Donald J. Mabbott et al.   NEUROPSYCHOLOGY

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

(2008) C.-S. Lee et al.   NUCLEIC ACIDS RESEARCH

ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding

(2008) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DEAD-Box RNA Helicase Ded1p Affects and Accumulates in Saccharomyces cerevisiae P-Bodies

(2007) Carla Beckham et al.   MOLECULAR BIOLOGY OF THE CELL