New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements

(2011) Danielle Cass et al.   BMC MOLECULAR BIOLOGY

RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP

(2011) Warunee Dansithong et al.   EMBO REPORTS

Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms

(2011) Hélène Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expanded CUG Repeats Dysregulate RNA Splicing by Altering the Stoichiometry of the Muscleblind 1 Complex

(2011) Sharan Paul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoregulated Splicing ofmuscleblind-like 1 (MBNL1) Pre-mRNA

(2011) Devika P. Gates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5' Splice Site

(2011) A. Kar et al.   MOLECULAR AND CELLULAR BIOLOGY

Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy

(2011) Frédérique Rau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Taming free energy landscapes with RNA chaperones

(2011) Sarah A. Woodson   RNA Biology

Myotonic Dystrophies 1 and 2: Complex Diseases with Complex Mechanisms

(2010) Benedikt Schoser et al.   CURRENT GENOMICS

CELF and PTB proteins modulate the inclusion of the β-tropomyosin exon 6B during myogenic differentiation

(2010) Alain Sureau et al.   EXPERIMENTAL CELL RESEARCH

Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs

(2010) Virginie François et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases

(2010) Agnieszka Kiliszek et al.   NUCLEIC ACIDS RESEARCH

Identification of MBNL1 and MBNL3 domains required for splicing activation and repression

(2010) Ioannis Grammatikakis et al.   NUCLEIC ACIDS RESEARCH

P68 RNA helicase is a nucleocytoplasmic shuttling protein

(2009) Haizhen Wang et al.   CELL RESEARCH

Dystrophia myotonia: why focus on foci?

(2009) R P Junghans   EUROPEAN JOURNAL OF HUMAN GENETICS

Immortalized Skin Fibroblasts Expressing Conditional MyoD as a Renewable and Reliable Source of Converted Human Muscle Cells to Assess Therapeutic Strategies for Muscular Dystrophies: Validation of an Exon-Skipping Approach to Restore Dystrophin in Duchenne Muscular Dystrophy Cells

(2009) Soraya Chaouch et al.   HUMAN GENE THERAPY

The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing

(2009) M. B. Warf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of RNA-mediated Disease

(2008) Jason R. O'Rourke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Phenylalanine of Motif IV in Superfamily 2 Helicases Is Required for Cooperative, ATP-Dependent Binding of RNA Substrates in DEAD-Box Proteins

(2008) J. Banroques et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1

(2008) Marianna Teplova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila

(2008) Amparo Garcia-Lopez et al.   PLoS One

P68 RNA Helicase (DDX5) Alters Activity of Cis- and Trans-Acting Factors of the Alternative Splicing of H-Ras

(2008) Maria Camats et al.   PLoS One