Properties of FDA-approved small molecule protein kinase inhibitors: A 2023 update
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Properties of FDA-approved small molecule protein kinase inhibitors: A 2023 update
Authors
Keywords
-
Journal
PHARMACOLOGICAL RESEARCH
Volume 187, Issue -, Pages 106552
Publisher
Elsevier BV
Online
2022-11-18
DOI
10.1016/j.phrs.2022.106552
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Asciminib: First Approval
- (2022) Emma D. Deeks DRUGS
- Treatment‐free remission in patients with chronic myeloid leukemia following the discontinuation of tyrosine kinase inhibitors
- (2022) Fadi G. Haddad et al. AMERICAN JOURNAL OF HEMATOLOGY
- Pacritinib: First Approval
- (2022) Yvette N. Lamb DRUGS
- Targeting BCR-Abl in the treatment of Philadelphia-chromosome positive chronic myelogenous leukemia
- (2022) Robert Roskoski PHARMACOLOGICAL RESEARCH
- A Comprehensive Overview of Globally Approved JAK Inhibitors
- (2022) Ahmed M. Shawky et al. Pharmaceutics
- Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
- (2022) Chris Arter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders
- (2022) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Pacritinib for the treatment of patients with myelofibrosis and thrombocytopenia
- (2022) John Mascarenhas Expert Review of Hematology
- The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
- (2021) Carrow I. Wells et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases
- (2021) Zhouling Xie et al. JOURNAL OF MEDICINAL CHEMISTRY
- Properties of FDA-approved small molecule protein kinase inhibitors: a 2021 update
- (2021) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Orally effective FDA-approved protein kinase targeted covalent inhibitors (TCIs)
- (2021) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Posttranslational modifications as therapeutic targets for intestinal disorders
- (2021) Jieun Choo et al. PHARMACOLOGICAL RESEARCH
- From structure to the dynamic regulation of a molecular switch: A journey over three decades
- (2021) Susan S. Taylor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies
- (2021) Paul D. Leeson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Kinase drug discovery 20 years after imatinib: progress and future directions
- (2021) Philip Cohen et al. NATURE REVIEWS DRUG DISCOVERY
- Chronic myeloid leukaemia
- (2021) Jorge Cortes et al. LANCET
- Trends in kinase drug discovery: targets, indications and inhibitor design
- (2021) Misty M. Attwood et al. NATURE REVIEWS DRUG DISCOVERY
- Properties of FDA-approved small molecule phosphatidylinositol 3-kinase inhibitors prescribed for the treatment of malignancies
- (2021) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Hydrophobic and polar interactions of FDA-approved small molecule protein kinase inhibitors with their target enzymes
- (2021) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Crowdsourced mapping of unexplored target space of kinase inhibitors
- (2021) Anna Cichońska et al. Nature Communications
- Futibatinib, an irreversible FGFR1-4 inhibitor, in patients with advanced solid tumors harboring FGF/FGFR aberrations: a phase I dose-expansion study
- (2021) Funda Meric-Bernstam et al. Cancer Discovery
- The cure of leukemia through the optimist's prism
- (2021) Hagop M. Kantarjian et al. CANCER
- Abrocitinib: First Approval
- (2021) Emma D. Deeks et al. DRUGS
- Small Molecule Kinase Inhibitor Drugs (1995–2021): Medical Indication, Pharmacology, and Synthesis
- (2021) Cecilia C. Ayala-Aguilera et al. JOURNAL OF MEDICINAL CHEMISTRY
- Kincore: a web resource for structural classification of protein kinases and their inhibitors
- (2021) Vivek Modi et al. NUCLEIC ACIDS RESEARCH
- Blockade of mutant RAS oncogenic signaling with a special emphasis on KRAS
- (2021) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update
- (2021) Robert Roskoski Jr. PHARMACOLOGICAL RESEARCH
- The role of small molecule Flt3 receptor protein-tyrosine kinase inhibitors in the treatment of Flt3-positive acute myelogenous leukemias
- (2020) Robert Roskoski PHARMACOLOGICAL RESEARCH
- TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure
- (2019) Maria Kalyukina et al. ChemMedChem
- Defining a new nomenclature for the structures of active and inactive kinases
- (2019) Vivek Modi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Properties of FDA-approved small molecule protein kinase inhibitors
- (2019) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Targeting ERK1/2 protein-serine/threonine kinases in human cancers
- (2019) Robert Roskoski PHARMACOLOGICAL RESEARCH
- TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma
- (2019) Lipika Goyal et al. Cancer Discovery
- The new entries in the therapeutic armamentarium: The small molecule JAK inhibitors
- (2019) Katie Bechman et al. PHARMACOLOGICAL RESEARCH
- Surprising Non-Additivity of Methyl Groups in Drug–Kinase Interaction
- (2019) Barbara Wienen-Schmidt et al. ACS Chemical Biology
- The Landscape of Atypical and Eukaryotic Protein Kinases
- (2019) Georgi K. Kanev et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- New Promise and Opportunities for Allosteric Kinase Inhibitors
- (2019) Xiaoyun Lu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder
- (2019) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update
- (2019) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
- (2018) Michael L. Vazquez et al. JOURNAL OF MEDICINAL CHEMISTRY
- PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials
- (2018) Fabrice Carles et al. MOLECULES
- Unexplored therapeutic opportunities in the human genome
- (2018) Tudor I. Oprea et al. NATURE REVIEWS DRUG DISCOVERY
- Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers
- (2018) Robert Roskoski et al. PHARMACOLOGICAL RESEARCH
- The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders
- (2018) Robert Roskoski PHARMACOLOGICAL RESEARCH
- The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
- (2018) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
- (2018) Joseph Schoepfer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting oncogenic Raf protein-serine/threonine kinases in human cancers
- (2018) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers
- (2018) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs
- (2018) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Anaplastic lymphoma kinase (ALK) inhibitors in the treatment of ALK-driven lung cancers
- (2017) Robert Roskoski PHARMACOLOGICAL RESEARCH
- ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers
- (2017) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas
- (2017) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas
- (2017) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Molecular inflation, attrition and the rule of five
- (2016) Paul D. Leeson ADVANCED DRUG DELIVERY REVIEWS
- Quality guidelines for oral drug candidates: dose, solubility and lipophilicity
- (2016) Martin K. Bayliss et al. DRUG DISCOVERY TODAY
- Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview
- (2016) Peter M. Fischer MEDICINAL RESEARCH REVIEWS
- Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes
- (2016) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs
- (2016) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms
- (2016) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases
- (2016) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Use of Second- and Third-Generation Tyrosine Kinase Inhibitors in the Treatment of Chronic Myeloid Leukemia: An Evolving Treatment Paradigm
- (2015) Elias Jabbour et al. Clinical Lymphoma Myeloma & Leukemia
- AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective
- (2015) Samuel H. Myers et al. JOURNAL OF MEDICINAL CHEMISTRY
- KLIFS: a structural kinase-ligand interaction database
- (2015) Albert J. Kooistra et al. NUCLEIC ACIDS RESEARCH
- Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods
- (2015) Sean Ekins et al. PHARMACEUTICAL RESEARCH
- A historical overview of protein kinases and their targeted small molecule inhibitors
- (2015) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors
- (2015) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Dynamics-Driven Allostery in Protein Kinases
- (2015) Alexandr P. Kornev et al. TRENDS IN BIOCHEMICAL SCIENCES
- FDA-approved small-molecule kinase inhibitors
- (2015) Peng Wu et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trials
- (2015) Koji Sasaki et al. Lancet Haematology
- Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery
- (2014) Timothy J. Ritchie et al. JOURNAL OF MEDICINAL CHEMISTRY
- The role of ligand efficiency metrics in drug discovery
- (2014) Andrew L. Hopkins et al. NATURE REVIEWS DRUG DISCOVERY
- ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors
- (2014) Robert Roskoski PHARMACOLOGICAL RESEARCH
- The preclinical profile of crizotinib for the treatment of non-small-cell lung cancer and other neoplastic disorders
- (2013) Robert Roskoski Expert Opinion on Drug Discovery
- KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space
- (2013) Oscar P. J. van Linden et al. JOURNAL OF MEDICINAL CHEMISTRY
- Polyproline-II Helix in Proteins: Structure and Function
- (2013) Alexei A. Adzhubei et al. JOURNAL OF MOLECULAR BIOLOGY
- The ErbB/HER family of protein-tyrosine kinases and cancer
- (2013) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation
- (2013) Hiruy S. Meharena et al. PLOS BIOLOGY
- New Directions in Targeting Protein Kinases: Focusing Upon True Allosteric and Bivalent Inhibitors
- (2012) Vandana Lamba et al. CURRENT PHARMACEUTICAL DESIGN
- The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction
- (2012) Bernard A. Liu et al. FEBS LETTERS
- Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer
- (2012) J. Jean Cui et al. JOURNAL OF MEDICINAL CHEMISTRY
- ERK1/2 MAP kinases: Structure, function, and regulation
- (2012) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
- (2012) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Approaches to discover non-ATP site kinase inhibitors
- (2012) Lori Krim Gavrin et al. MedChemComm
- The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling
- (2011) Arvin C. Dar et al. Annual Review of Biochemistry
- MEK1/2 dual-specificity protein kinases: Structure and regulation
- (2011) Robert Roskoski BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Protein kinase biochemistry and drug discovery
- (2011) Phillip A. Schwartz et al. BIOORGANIC CHEMISTRY
- Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site
- (2011) Jingsong Yang et al. CHEMISTRY & BIOLOGY
- RAF protein-serine/threonine kinases: Structure and regulation
- (2010) Robert Roskoski BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- cAMP-dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer
- (2010) Madhusudan et al. PROTEIN SCIENCE
- Defining the conserved internal architecture of a protein kinase
- (2009) Alexandr P. Kornev et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation
- (2009) Fabio Zuccotto et al. JOURNAL OF MEDICINAL CHEMISTRY
- A helix scaffold for the assembly of active protein kinases
- (2008) A. P. Kornev et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now