Defining a new nomenclature for the structures of active and inactive kinases

Estimating Electron Density Support for Individual Atoms and Molecular Fragments in X-ray Structures

(2017) Agnes Meyder et al.   Journal of Chemical Information and Modeling

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

(2017) Michael Tong et al.   Nature Communications

The ABC of protein kinase conformations

(2015) Henrik Möbitz   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit

(2015) Daniel A. Keedy et al.   PLoS Computational Biology

Detection oftrans–cisflips and peptide-plane flips in protein structures

(2015) Wouter G. Touw et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation pathway of Src kinase reveals intermediate states as targets for drug design

(2014) Diwakar Shukla et al.   Nature Communications

KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space

(2013) Oscar P. J. van Linden et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transitions to catalytically inactive conformations in EGFR kinase

(2013) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

(2012) Valentina Grossi et al.   CANCER BIOLOGY & THERAPY

Integrating Ligand-Based and Protein-Centric Virtual Screening of Kinase Inhibitors Using Ensembles of Multiple Protein Kinase Genes and Conformations

(2012) Anshuman Dixit et al.   Journal of Chemical Information and Modeling

KIDFamMap: a database of kinase-inhibitor-disease family maps for kinase inhibitor selectivity and binding mechanisms

(2012) Yi-Yuan Chiu et al.   NUCLEIC ACIDS RESEARCH

A Smoothed Backbone-Dependent Rotamer Library for Proteins Derived from Adaptive Kernel Density Estimates and Regressions

(2011) Maxim V. Shapovalov et al.   STRUCTURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

(2010) Charlotte A. Dodson et al.   BIOCHEMICAL JOURNAL

A New Clustering of Antibody CDR Loop Conformations

(2010) Benjamin North et al.   JOURNAL OF MOLECULAR BIOLOGY

An enriched structural kinase database to enable kinome-wide structure-based analyses and drug discovery

(2010) Natasja Brooijmans et al.   PROTEIN SCIENCE

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories

(2009) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase inhibitors: contributions from structure to clinical compounds

(2009) Louise N. Johnson   QUARTERLY REVIEWS OF BIOPHYSICS