Kincore: a web resource for structural classification of protein kinases and their inhibitors

Extending the New Generation of Structure Predictors to Account for Dynamics and Allostery

(2021) Sarel J. Fleishman et al.   JOURNAL OF MOLECULAR BIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Hydrophobic and polar interactions of FDA-approved small molecule protein kinase inhibitors with their target enzymes

(2021) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl

(2020) Fabian Paul et al.   Journal of Chemical Theory and Computation

ProtCID: a data resource for structural information on protein interactions

(2020) Qifang Xu et al.   Nature Communications

Genome‐wide and structural analyses of pseudokinases encoded in the genome of Arabidopsis thaliana provide functional insights

(2020) Anindita Paul et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

KLIFS: an overhaul after the first 5 years of supporting kinase research

(2020) Georgi K Kanev et al.   NUCLEIC ACIDS RESEARCH

Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation

(2020) Sven M. Lange et al.   STRUCTURE

Defining a new nomenclature for the structures of active and inactive kinases

(2019) Vivek Modi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)

(2019) Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains

(2019) Vivek Modi et al.   Scientific Reports

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

KinaMetrix: a web resource to investigate kinase conformations and inhibitor space

(2018) Rayees Rahman et al.   NUCLEIC ACIDS RESEARCH

Estimating Electron Density Support for Individual Atoms and Molecular Fragments in X-ray Structures

(2017) Agnes Meyder et al.   Journal of Chemical Information and Modeling

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

(2017) Huaibin Chen et al.   eLife

The ABC of protein kinase conformations

(2015) Henrik Möbitz   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Exploring Protein Kinase Conformation Using Swarm-Enhanced Sampling Molecular Dynamics

(2014) Alessio Atzori et al.   Journal of Chemical Information and Modeling

Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

(2014) R. S. K. Vijayan et al.   JOURNAL OF MEDICINAL CHEMISTRY

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space

(2013) Oscar P. J. van Linden et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases

(2013) K. Oruganty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIFTS: Structure Integration with Function, Taxonomy and Sequences resource

(2012) Sameer Velankar et al.   NUCLEIC ACIDS RESEARCH

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

(2010) J. H. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An enriched structural kinase database to enable kinome-wide structure-based analyses and drug discovery

(2010) Natasja Brooijmans et al.   PROTEIN SCIENCE

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

A conserved protonation-dependent switch controls drug binding in the Abl kinase

(2008) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA