Therapeutic health effects of ginger (Zingiber officinale): updated narrative review exploring the mechanisms of action

Orally consumed ginger and human health: an umbrella review

(2022) Megan Crichton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Bentong ginger oleoresin mitigates liver injury and modulates gut microbiota in mouse with nonalcoholic fatty liver disease induced by high‐fat diet

(2022) Kunli Wang et al.   JOURNAL OF FOOD SCIENCE

A systematic review and meta‐analysis of preclinical and clinical studies on the efficacy of ginger for the treatment of fatty liver disease

(2022) Mehnoosh Samadi et al.   PHYTOTHERAPY RESEARCH

Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance

(2022) Anil Kumar et al.   Theranostics

Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities

(2022) Chuan Liu et al.   Frontiers in Medicine

Biochemical analysis reveals the systematic response of motion sickness mice to ginger (Zingiber officinale) extract's amelioration effect

(2022) Wanlin Zhong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

(2021) Meenakshi Venkateswaran et al.   JOURNAL OF FOOD BIOCHEMISTRY

6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity

(2021) Mohammed A. Alsahli et al.   MEDIATORS OF INFLAMMATION

Ginger (Zingiber officinale) Attenuates Obesity and Adipose Tissue Remodeling in High-Fat Diet-Fed C57BL/6 Mice

(2021) Seok Hee Seo et al.   International Journal of Environmental Research and Public Health

Gut Microbiota Variation With Short-Term Intake of Ginger Juice on Human Health

(2021) Xiaolong Wang et al.   Frontiers in Microbiology

Ginger Alleviates DSS-Induced Ulcerative Colitis Severity by Improving the Diversity and Function of Gut Microbiota

(2021) Shanshan Guo et al.   Frontiers in Pharmacology

6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation

(2021) Saleh A. Almatroodi et al.   Pharmaceutics

[6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication

(2021) Rahma F. Hayati et al.   Biomed Research International

Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

(2021) Weixia Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

(2021) Mariia Zadorozhna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

(2020) Youn Hee Nam et al.   Nutrients

Leptin: Less Is More

(2020) Shangang Zhao et al.   DIABETES

Antifungal and anti‐biofilm effects of 6‐shogaol against Candida auris

(2020) H.‐R. Kim et al.   JOURNAL OF APPLIED MICROBIOLOGY

Antibacterial Activity and Mechanism of Ginger Essential Oil against Escherichia coli and Staphylococcus aureus

(2020) Xin Wang et al.   MOLECULES

Ginger ( Zingiber officinale Rosc.) and its bioactive components are potential resources for health beneficial agents

(2020) Mengmeng Zhang et al.   PHYTOTHERAPY RESEARCH

Ginger Extract Increases GLUT-4 Expression Preferentially Through AMPK Than PI3K Signalling Pathways in C2C12 Muscle Cells

(2020) Marjan Tajik Kord et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Clostridium ramosum regulates enterochromaffin cell development and serotonin release

(2019) Ana D. Mandić et al.   Scientific Reports

Beneficial effects of ginger on prevention of obesity through modulation of gut microbiota in mice

(2019) Jing Wang et al.   EUROPEAN JOURNAL OF NUTRITION

6-Gingerol, an active pungent component of ginger, inhibits L-type Ca2+ current, contractility, and Ca2+ transients in isolated rat ventricular myocytes

(2019) Xue Han et al.   Food Science & Nutrition

The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis

(2019) Naheed Aryaeian et al.   GENE

Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice

(2019) Jing Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

(2019) Giorgia Schena et al.   Cells

Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

(2019) Qian-Qian Mao et al.   Foods

Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems

(2019) Li Tian et al.   Journal of Natural Medicines

Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model

(2019) Gene T. Yocum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

6-Gingerol, a Functional Polyphenol of Ginger, Promotes Browning through an AMPK-Dependent Pathway in 3T3-L1 Adipocytes

(2019) Jing Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Research Progress on Chemical Constituents of Zingiber officinale Roscoe

(2019) Yan Liu et al.   Biomed Research International

6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE−/− Mice Exposed to Chronic Mild Stress

(2018) Shuai Wang et al.   Cardiovascular Toxicology

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

(2018) Jaismy Jacob P et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The hidden mechanism beyond ginger ( Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity

(2018) Shahira M. Ezzat et al.   JOURNAL OF ETHNOPHARMACOLOGY

[6]-Gingerol-induced cell cycle arrest, reactive oxygen species generation, and disruption of mitochondrial membrane potential are associated with apoptosis in human gastric cancer (AGS) cells

(2018) Debjani P. Mansingh et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

(2018) Yun Teng et al.   Cell Host & Microbe

Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase

(2018) Junhong Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ginger attenuates trimethylamine-N-oxide (TMAO)-exacerbated disturbance in cholesterol metabolism and vascular inflammation

(2018) Zouyan He et al.   Journal of Functional Foods

Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue

(2018) Seunghae Kim et al.   Nutrients

Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms

(2017) Nahla E. El-Ashmawy et al.   EUROPEAN JOURNAL OF NUTRITION

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway

(2017) Chethan Sampath et al.   FOOD CHEMISTRY

Interindividual Variability in Metabolism of [6]-Shogaol by Gut Microbiota

(2017) Pei Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis

(2017) Nissar Ahmad Wani et al.   MOLECULAR CANCER RESEARCH

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice

(2017) Sujin Suk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Determination of the concentration of major active anti-emetic constituents within commercial ginger food products and dietary supplements

(2017) Wolfgang Marx et al.   European Journal of Integrative Medicine

Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

(2017) Soojung Oh et al.   Journal of Functional Foods

Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis

(2017) Jiyun Ahn et al.   Oncotarget

Erratum to: Synthetic and natural antioxidants attenuate cisplatin-induced vomiting

(2017) Javaid Alam et al.   BMC Pharmacology & Toxicology

[6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells

(2016) Govindhan Annamalai et al.   BIOMEDICINE & PHARMACOTHERAPY

Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

(2016) Mehran Rahimlou et al.   Hepatitis Monthly

Ginger Essential Oil Ameliorates Hepatic Injury and Lipid Accumulation in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease

(2016) Yi-Syuan Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In silico investigation into the interactions between murine 5-HT 3 receptor and the principle active compounds of ginger ( Zingiber officinale )

(2016) Anna E. Lohning et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation

(2016) Yoshiyuki Kawamoto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study

(2016) Katsuya Ohbuchi et al.   PLoS One

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

(2015) Wolfgang Marx et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT

(2015) Vahideh Ebrahimzadeh Attari et al.   EUROPEAN JOURNAL OF NUTRITION

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Chromatographic analysis, antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds

(2015) Shivraj Hariram Nile et al.   INDUSTRIAL CROPS AND PRODUCTS

A Bioactive Constituent of Ginger, 6-Shogaol, Prevents Adipogenesis and Stimulates Lipolysis in 3T3-L1 Adipocytes

(2015) Sujin Suk et al.   JOURNAL OF FOOD BIOCHEMISTRY

Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway

(2015) Koichi Misawa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of gingerol on colonic motilityviainhibition of calcium channel currents in rats

(2015) Zheng-Xu Cai   WORLD JOURNAL OF GASTROENTEROLOGY

Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats

(2015) Ayodele Jacob Akinyemi et al.   Journal of Functional Foods

Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

(2015) Miho Akimoto et al.   PLoS One

6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death

(2015) Anasuya Ray et al.   PLoS One

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF- B Signaling

(2014) A. Saha et al.   Cancer Prevention Research

Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion

(2014) Lin Lei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ginger and Its Pungent Constituents Non-Competitively Inhibit Serotonin Currents on Visceral Afferent Neurons

(2014) Zhenhua Jin et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation

(2014) Faizul Azam et al.   Drug Design Development and Therapy

Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension

(2014) Quynh N. Dinh et al.   Biomed Research International

6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation

(2013) Gunhyuk Park et al.   ACTA PHARMACOLOGICA SINICA

Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation

(2013) Elizabeth A. Townsend et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Attenuation of Proinflammatory Responses byS-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells

(2013) Xiao-Hong Li et al.   Evidence-based Complementary and Alternative Medicine

Aqueous Extracts of Two Varieties of Ginger (Zingiber officinale) Inhibit Angiotensin I–Converting Enzyme, Iron(II), and Sodium Nitroprusside-Induced Lipid Peroxidation in the Rat Heart In Vitro

(2013) Ayodele J. Akinyemi et al.   JOURNAL OF MEDICINAL FOOD

Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3receptors of enteric neurons

(2013) J. Walstab et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Serotonin and hypothalamic control of hunger: a review

(2013) Fernanda de Matos Feijó et al.   Revista da Associacao Medica Brasileira

Effect of ginger (Zingiber officinale Roscoe) on growth performance, nutrient digestibility, serum metabolites, gut morphology, and microflora of growing guinea fowl

(2013) Abimbola Oladele Oso et al.   TROPICAL ANIMAL HEALTH AND PRODUCTION

Treatment with Ginger Ameliorates Fructose-Induced Fatty Liver and Hypertriglyceridemia in Rats: Modulation of the Hepatic Carbohydrate Response Element-Binding Protein-Mediated Pathway

(2012) Huanqing Gao et al.   Evidence-based Complementary and Alternative Medicine

Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats

(2012) Manal A. Hamed et al.   TheScientificWorldJOURNAL

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

Regulation of Low-Density Lipoprotein Receptor and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High-Fat Diet-Fed Rats

(2010) Srinivas Nammi et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)

(2010) Richard B. van Breemen et al.   FITOTERAPIA

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

(2010) Akitoshi Asami et al.   Journal of Natural Medicines

Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats

(2010) El-Sayed M. ElRokh et al.   INFLAMMOPHARMACOLOGY

6-Gingerol inhibits ROS and iNOS through the suppression of PKC-α and NF-κB pathways in lipopolysaccharide-stimulated mouse macrophages

(2009) Tzung-Yan Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase

(2009) Chul-Ho Jeong et al.   CANCER RESEARCH

Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research

(2007) Badreldin H. Ali et al.   FOOD AND CHEMICAL TOXICOLOGY