Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds

(2014) Dong-Liang Lu et al.   FOOD CHEMISTRY

(6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression

(2014) Namrata Rastogi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling

(2014) EK Radhakrishnan et al.   PLoS One

Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells

(2014) Dae-Hee Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel strategies for managing pancreatic cancer

(2014) Welley S Loc   WORLD JOURNAL OF GASTROENTEROLOGY

6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ)

(2013) Boon Shing Tan et al.   CANCER LETTERS

Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells

(2013) Chao Zhang et al.   CANCER LETTERS

Effects of Ginger Supplementation on Cell-Cycle Biomarkers in the Normal-Appearing Colonic Mucosa of Patients at Increased Risk for Colorectal Cancer: Results from a Pilot, Randomized, and Controlled Trial

(2013) J. Citronberg et al.   Cancer Prevention Research

Ginger: Is it Ready for Prime Time?

(2013) G. D. Stoner   Cancer Prevention Research

[6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2

(2013) Myoung Ok Kim et al.   CARCINOGENESIS

6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α

(2013) Qun Liu et al.   Molecular Cancer

The HSP70 and Autophagy Inhibitor Pifithrin-  Enhances the Antitumor Effects of TRAIL on Human Pancreatic Cancer

(2013) H. Monma et al.   MOLECULAR CANCER THERAPEUTICS

Toward a Better Understanding of Pancreatic Ductal Adenocarcinoma

(2013) Christian Partensky   PANCREAS

Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation

(2013) Yingdong Zhu et al.   PLoS One

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells

(2012) Yoshihide Shimojo et al.   CLINICAL & EXPERIMENTAL METASTASIS

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin

(2012) Feng Li et al.   FOOD CHEMISTRY

6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells and Exhibits Anti-Tumor Activity In Vivo through Endoplasmic Reticulum Stress

(2012) Rong Hu et al.   PLoS One

Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodide-negative cells

(2011) Hirofumi Sawai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benefits of whole ginger extract in prostate cancer

(2011) Prasanthi Karna et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

(2011) Hirotake Imanishi et al.   PLoS One

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting

(2008) Suzanna M. Zick et al.   SUPPORTIVE CARE IN CANCER