eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells

The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes

(2022) Ruirui Jia et al.   NUCLEIC ACIDS RESEARCH

Pervasive translation of circular RNAs driven by short IRES-like elements

(2022) Xiaojuan Fan et al.   Nature Communications

Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

(2022) Liang Chen et al.   Nature Communications

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling

(2021) Xinya Gao et al.   NATURE CELL BIOLOGY

HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein

(2021) Yan Li et al.   Advanced Science

Structured elements drive extensive circular RNA translation

(2021) Chun-Kan Chen et al.   MOLECULAR CELL

Gawky modulates MTF-1-mediated transcription activation and metal discrimination

(2021) Ruirui Jia et al.   NUCLEIC ACIDS RESEARCH

RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus

(2021) Jin You et al.   Cell Discovery

EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression

(2021) Zhen-hua Feng et al.   Cell Death & Disease

Circular RNAs in physiology and non-immunological diseases

(2021) Liang Chen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Translation and functional roles of circular RNAs in human cancer

(2020) Ming Lei et al.   Molecular Cancer

Biogenesis and Functions of Circular RNAs Come into Focus

(2020) Mei-Sheng Xiao et al.   TRENDS IN CELL BIOLOGY

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

(2020) Xiaying Zheng et al.   Molecular Cancer

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The new function of circRNA: translation

(2020) Y. Shi et al.   Clinical & Translational Oncology

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

(2020) Carina Marianne Weigelt et al.   MOLECULAR CELL

The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery

(2020) Katherine L.B. Borden et al.   RNA Biology

CircRNA inhibits DNA damage repair by interacting with host gene

(2020) Xiaolong Xu et al.   Molecular Cancer

TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence

(2020) Wendi Huang et al.   NUCLEIC ACIDS RESEARCH

Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus

(2020) Zhenxing Song et al.   Science China-Life Sciences

Circular RNAs in Immune Response and Viral Infection

(2020) Lichong Yan et al.   TRENDS IN BIOCHEMICAL SCIENCES

New progresses of circular RNA biology: from nuclear export to degradation

(2020) Min Zhou et al.   RNA Biology

Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts

(2020) Anthony Bochler et al.   Cell Reports

The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome

(2020) A. Bronisz et al.   Science Advances

Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP

(2019) Fangfang Wu et al.   JOURNAL OF NEUROSCIENCE

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Repression of ferritin light chain translation by human eIF3

(2019) Mia C Pulos-Holmes et al.   eLife

Defining an evolutionarily conserved role of GW182 in circular RNA degradation

(2019) Ruirui Jia et al.   Cell Discovery

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively

(2019) Anna Herrmannová et al.   NUCLEIC ACIDS RESEARCH

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs

(2018) Chuan Huang et al.   GENES & DEVELOPMENT

Engineering circular RNA for potent and stable translation in eukaryotic cells

(2018) R. Alexander Wesselhoeft et al.   Nature Communications

EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis

(2018) Renjie Wang et al.   Molecular Cancer

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

(2018) Maolei Zhang et al.   Nature Communications

Non-AUG translation: a new start for protein synthesis in eukaryotes

(2017) Michael G. Kearse et al.   GENES & DEVELOPMENT

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

(2017) Leoš Shivaya Valášek et al.   NUCLEIC ACIDS RESEARCH

eIF3: a factor for human health and disease

(2017) Andreia Gomes-Duarte et al.   RNA Biology

Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation

(2017) Alan G. Hinnebusch   TRENDS IN BIOCHEMICAL SCIENCES

The translation factors of Drosophila melanogaster

(2016) Steven J. Marygold et al.   FLY

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition

(2016) Angelita Simonetti et al.   MOLECULAR CELL

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

(2016) Amy S. Y. Lee et al.   NATURE

Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer

(2016) Susan Wagner et al.   NUCLEIC ACIDS RESEARCH

An mRNA-specific tRNAicarrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A

(2016) Oh Sung Kwon et al.   NUCLEIC ACIDS RESEARCH

Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans

(2016) Douglas J. Cattie et al.   PLoS Genetics

Combinatorial control ofDrosophilacircular RNA expression by intronic repeats, hnRNPs, and SR proteins

(2015) Marianne C. Kramer et al.   GENES & DEVELOPMENT

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

(2015) Amy S. Y. Lee et al.   NATURE

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Metazoan tRNA introns generate stable circular RNAs in vivo

(2015) Zhipeng Lu et al.   RNA

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNAi pathway participates in chromosome segregation in mammalian cells

(2015) Chuan Huang et al.   Cell Discovery

Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?

(2015) Martin Holcik   Frontiers in Oncology

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled

(2014) Michael J. Osborne et al.   IMMUNOLOGICAL REVIEWS

Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAiTernary Complex and eIF3 Stabilize the 43 S Preinitiation Complex

(2014) Masaaki Sokabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and Biochemical Characterization of Human Eukaryotic Translation Initiation Factor 3 in Living Cells

(2014) Susan Wagner et al.   MOLECULAR AND CELLULAR BIOLOGY

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation

(2014) Shifeng Xue et al.   NATURE

Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes

(2014) Sohail Khoshnevis et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

The Role of Heat Shock Response in Insulin Resistance and Diabetes

(2014) Tatsuya Kondo et al.   Diabetes & Metabolism Journal

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Predicting protein associations with long noncoding RNAs

(2011) Matteo Bellucci et al.   NATURE METHODS

Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

(2010) M. A. Skabkin et al.   GENES & DEVELOPMENT

GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor

(2010) Sergey E. Dmitriev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Indispensable N-Terminal Half of eIF3j/HCR1 Cooperates with its Structurally Conserved Binding Partner eIF3b/PRT1-RRM and with eIF1A in Stringent AUG Selection

(2010) Latifa ElAntak et al.   JOURNAL OF MOLECULAR BIOLOGY

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Initiation Factor eIF2-independent Mode of c-Src mRNA Translation Occurs via an Internal Ribosome Entry Site

(2009) Heba Allam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mRNA nuclear export at a glance

(2009) S. R. Carmody et al.   JOURNAL OF CELL SCIENCE

eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II

(2008) Tatyana V Pestova et al.   EMBO JOURNAL

Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2

(2008) Ilya M Terenin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Vienna RNA Websuite

(2008) A. R. Gruber et al.   NUCLEIC ACIDS RESEARCH

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3

(2008) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA