Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condensates

Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning

(2022) Juan M. Iglesias-Artola et al.   Nature Chemistry

Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development

(2022) Mainak Bose et al.   CELL

A prebiotically plausible scenario of an RNA–peptide world

(2022) Felix Müller et al.   NATURE

Condensates in RNA repeat sequences are heterogeneously organized and exhibit reptation dynamics

(2022) Hung T. Nguyen et al.   Nature Chemistry

Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains

(2022) Manas Seal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles

(2022) Saehyun Choi et al.   Nature Chemistry

Mesoscale structure–function relationships in mitochondrial transcriptional condensates

(2022) Marina Feric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active microrheology of protein condensates using colloidal probe-AFM

(2022) Xiufeng Li et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

(2021) Georg Krainer et al.   Nature Communications

In vivo reconstitution finds multivalent RNA-RNA interactions as drivers of mesh-like condensates

(2021) Weirui Ma et al.   eLife

Core–Shell Microcapsules from Unpurified Legume Flours

(2021) Xiufeng Li et al.   ACS Applied Materials & Interfaces

G-Quadruplex-Induced Liquid–Liquid Phase Separation in Biomimetic Protocells

(2021) Xuejiao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid–Liquid Phase Separation

(2021) Masahiro Mimura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

(2021) Shuai Wang et al.   NATURE CELL BIOLOGY

RNA modulates physiological and neuropathological protein phase transitions

(2021) Jacob R. Mann et al.   NEURON

Non-associative phase separation in an evaporating droplet as a model for prebiotic compartmentalization

(2021) Wei Guo et al.   Nature Communications

Photoswitchable single-stranded DNA-peptide coacervate formation as a dynamic system for reaction control

(2021) Wen Ann Wee et al.   iScience

RNA Droplets

(2020) Kevin Rhine et al.   Annual Review of Biophysics

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

Ionic solids from common colloids

(2020) Theodore Hueckel et al.   NATURE

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components

(2020) Jorge R. Espinosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid Crystal Coacervates Composed of Short Double-Stranded DNA and Cationic Peptides

(2020) Tommaso P. Fraccia et al.   ACS Nano

RNA-Mediated Feedback Control of Transcriptional Condensates

(2020) Jonathan E. Henninger et al.   CELL

Can coacervation unify disparate hypotheses in the origin of cellular life?

(2020) Basusree Ghosh et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

The glassiness of hardening protein droplets

(2020) Huaiying Zhang   SCIENCE

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

(2019) Raghav R. Poudyal et al.   Nature Communications

RNA structure maps across mammalian cellular compartments

(2019) Lei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

(2019) Steven Boeynaems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures trigger RNA phase separation

(2019) Yueying Zhang et al.   NUCLEIC ACIDS RESEARCH

Physiological, Pathological, and Targetable Membraneless Organelles in Neurons

(2019) Veronica H. Ryan et al.   TRENDS IN NEUROSCIENCES

Two-State Folding Energy Determination Based on Transition Points in Nonequilibrium Single-Molecule Experiments

(2018) Huijuan You et al.   Journal of Physical Chemistry Letters

Oligonucleotide–Peptide Complexes: Phase Control by Hybridization

(2018) Jeffrey R. Vieregg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Compartmentalised RNA catalysis in membrane-free coacervate protocells

(2018) Björn Drobot et al.   Nature Communications

Rigidity Rules in DNA Droplets: Nucleic Acid Flexibility Affects Model Membraneless Organelles

(2018) Alain A.M. André et al.   BIOPHYSICAL JOURNAL

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Origin of the RNA world: The fate of nucleobases in warm little ponds

(2017) Ben K. D. Pearce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

(2017) Marta M. Fay et al.   Cell Reports

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

Multiple and Cooperative Binding of Fluorescence Light-up Probe Thioflavin T with Human Telomere DNA G-Quadruplex

(2013) Valérie Gabelica et al.   BIOCHEMISTRY

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

(2013) Youn-Bok Lee et al.   Cell Reports

Origin of first cells at terrestrial, anoxic geothermal fields

(2012) A. Y. Mulkidjanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring enzyme activities under standardized in vivo-like conditions for systems biology

(2010) Karen van Eunen et al.   FEBS Journal

RNA Folding: Thermodynamic and Molecular Descriptions of the Roles of Ions

(2008) David E. Draper   BIOPHYSICAL JOURNAL