Multiomics of Colorectal Cancer Organoids Reveals Putative Mediators of Cancer Progression Resulting from SMAD4 Inactivation

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

(2022) Maria C. Heinz et al.   CANCER RESEARCH

DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)

(2022) Brad T Sherman et al.   NUCLEIC ACIDS RESEARCH

Smad4 and p53 synergize in suppressing autochthonous intestinal cancer

(2022) Jun Won Park et al.   Cancer Medicine

Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis

(2022) Hayet Bouzid et al.   Biomolecules

Diagnosis and Treatment of Metastatic Colorectal Cancer

(2021) Leah H. Biller et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A literature review on function and regulation mechanism of DKK4

(2021) Xiaoli Lou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis

(2021) Tian Fang et al.   BMC GASTROENTEROLOGY

Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

(2021) Nazia Chaudhary et al.   INTERNATIONAL JOURNAL OF CANCER

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

(2021) Dustin J. Flanagan et al.   NATURE

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

(2021) Sanne M. van Neerven et al.   NATURE

Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway

(2021) Wenyi Zhang et al.   ONCOGENE

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)

(2021) Shuang Gao et al.   Frontiers in Genetics

Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancer

(2021) Roelof A. Wester et al.   iScience

Dissecting the Role of the FGF19-FGFR4 Signaling Pathway in Cancer Development and Progression

(2020) Yanan Liu et al.   Frontiers in Cell and Developmental Biology

The Suppressing Effects of Dkk3 Expression on Aggressiveness and Tumorigenesis of Colorectal Cancer

(2020) Shuang Zhao et al.   Frontiers in Oncology

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

(2019) Nicola Ferrari et al.   Nature Communications

FXR Regulates Intestinal Cancer Stem Cell Proliferation

(2019) Ting Fu et al.   CELL

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer

(2019) Kodappully S. Siveen et al.   Cancers

Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor

(2019) Ming Wang et al.   Cancer Medicine

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment

(2019) Yoshiro Itatani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor organoid–T-cell coculture systems

(2019) Chiara M. Cattaneo et al.   Nature Protocols

SMAD4 suppresses WNT-driven de-differentiation and oncogenesis in the differentiated gut epithelium

(2018) Ansu O. Perekatt et al.   CANCER RESEARCH

NKG2D and its ligands in cancer

(2018) Payal Dhar et al.   CURRENT OPINION IN IMMUNOLOGY

DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

(2018) Qian Xiao et al.   NATURE MEDICINE

Proteome-wide identification of ubiquitin interactions using UbIA-MS

(2018) Xiaofei Zhang et al.   Nature Protocols

Perturbation-response genes reveal signaling footprints in cancer gene expression

(2018) Michael Schubert et al.   Nature Communications

β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells

(2018) Oksana Voloshanenko et al.   Scientific Reports

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

(2018) Koen C. Oost et al.   Cell Reports

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

(2018) Michitaka Nakano et al.   ONCOGENE

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma

(2018) Dongyang Wang et al.   DIGESTIVE DISEASES

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

(2018) Liran Zhou et al.   Science Translational Medicine

Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives

(2018) Amirsaeed Sabeti Aghabozorgi et al.   BIOCHIMIE

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Thyroid hormone promotes differentiation of colon cancer stem cells

(2017) Annunziata Gaetana Cicatiello et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

(2017) Kaja C. G. Berg et al.   Molecular Cancer

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Visualization and targeting of LGR5+ human colon cancer stem cells

(2017) Mariko Shimokawa et al.   NATURE

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

(2017) Arianna Fumagalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarker discovery by proteomics-based approaches for early detection and personalized medicine in colorectal cancer

(2017) Claudia Corbo et al.   Proteomics Clinical Applications

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

(2017) Alba Cristobal et al.   Cell Reports

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy

(2016) Saverio Candido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer

(2016) Yasufumi Matsuda et al.   CANCER SCIENCE

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition

(2016) Meibao Feng et al.   Molecular Cancer

DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells

(2016) Shengli He et al.   Oncology Letters

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The BioMart community portal: an innovative alternative to large, centralized data repositories

(2015) Damian Smedley et al.   NUCLEIC ACIDS RESEARCH

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

(2015) Antonio Colaprico et al.   NUCLEIC ACIDS RESEARCH

Dickkopf-3, a Tissue-Derived Modulator of Local T-Cell Responses

(2015) Michael Meister et al.   Frontiers in Immunology

Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer

(2015) Anne-Catherine Lhoumeau et al.   PLoS One

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma

(2014) Athina Vakrakou et al.   BIOLOGICAL CHEMISTRY

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC

(2014) P W Voorneveld et al.   BRITISH JOURNAL OF CANCER

Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK

(2014) Philip W. Voorneveld et al.   GASTROENTEROLOGY

Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis

(2014) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparing SILAC- and Stable Isotope Dimethyl-Labeling Approaches for Quantitative Proteomics

(2014) Ho-Tak Lau et al.   JOURNAL OF PROTEOME RESEARCH

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

The secretome signature of colon cancer cell lines

(2013) Esther Imperlini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer

(2013) Wen-jing Wu et al.   Journal of Translational Medicine

In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion

(2013) Rodrigo Barderas et al.   MOLECULAR & CELLULAR PROTEOMICS

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

The many roles of PTK7: A versatile regulator of cell–cell communication

(2012) Hanna Peradziryi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Selective enrichment of newly synthesized proteins for quantitative secretome analysis

(2012) Katrin Eichelbaum et al.   NATURE BIOTECHNOLOGY

Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance

(2012) M. Papatriantafyllou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TGFbeta Superfamily Signaling Pathway

(2012) Alexander Weiss et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction

(2011) Jae-Ho Bae et al.   CANCER SCIENCE

NGAL Expression Is Elevated in Both Colorectal Adenoma-Carcinoma Sequence and Cancer Progression and Enhances Tumorigenesis in Xenograft Mouse Models

(2011) Y. Sun et al.   CLINICAL CANCER RESEARCH

Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of β-Catenin

(2011) Tanner J. Freeman et al.   GASTROENTEROLOGY

Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

(2010) Ylenia Lombardo et al.   GASTROENTEROLOGY

Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells

(2010) Naveid Ahmad Ali et al.   Molecular BioSystems

Cancer secretomics reveal pathophysiological pathways in cancer molecular oncology

(2010) George S. Karagiannis et al.   Molecular Oncology

Epithelial to Mesenchymal Transition Is Impaired in Colon Cancer Cells With Microsatellite Instability

(2009) Maria S. Pino et al.   GASTROENTEROLOGY

Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome

(2009) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

NGAL decreases E-cadherin-mediated cell–cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells

(2009) Limei Hu et al.   LABORATORY INVESTIGATION

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

A role for the TGF -Par6 polarity pathway in breast cancer progression

(2009) A. M. Viloria-Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells

(2008) Rebecca S. Henkhaus et al.   BIOLOGICAL CHEMISTRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3

(2008) N Pendás-Franco et al.   ONCOGENE