Non-viral nucleic acid delivery approach: A boon for state-of-the-art gene delivery

The in vivo fate and targeting engineering of crossover vesicle-based gene delivery system

(2022) Xin-Chi Jiang et al.   ADVANCED DRUG DELIVERY REVIEWS

Current state of the art in peptide-based gene delivery

(2022) Roja Hadianamrei et al.   JOURNAL OF CONTROLLED RELEASE

DNA barcode-based detection of exosomal microRNAs using nucleic acid lateral flow assays for the diagnosis of colorectal cancer

(2022) Seokjoon Kim et al.   TALANTA

Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy

(2022) Marcela Tavares Luiz et al.   Pharmaceutics

In vivo fate and intracellular trafficking of vaccine delivery systems

(2022) Jaiwoo Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Insight and Perspective on Omicron’s Development, Behaviour, and Vaccine Breakthrough: Next Sequelae of COVID-19

(2022) Krishna Yadav et al.   Journal of Young Pharmacists

Nano-constructs targeting the primary cellular energy source of cancer cells for modulating tumor progression

(2022) Krishna Yadav et al.   OpenNano

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

(2021) Yvonne Kohl et al.   Small

Synthetic Receptor-Based Targeting Strategies to Improve Tumor Drug Delivery

(2021) Susheel Kumar Nethi et al.   AAPS PHARMSCITECH

Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic

(2021) Annette I.S. van den Berg et al.   JOURNAL OF CONTROLLED RELEASE

International Collaboration to Ensure Equitable Access to Vaccines for COVID‐19: The ACT‐Accelerator and the COVAX Facility

(2021) MARK ECCLESTON‐TURNER et al.   MILBANK QUARTERLY

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

(2021) Muhammad Abdur Rahim et al.   Cancers

mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents

(2021) Susanne Rauch et al.   npj Vaccines

Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects

(2021) Hui Zu et al.   AAPS Journal

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Nucleic Acid Delivery for Therapeutic Applications

(2021) Akash Gupta et al.   ADVANCED DRUG DELIVERY REVIEWS

Supply and delivery of vaccines for global health

(2021) Jean-Louis Excler et al.   CURRENT OPINION IN IMMUNOLOGY

Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies

(2021) Krishna Yadav et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

COVID-19: clinical presentation and detection methods

(2021) Madhulika Pradhan et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

(2021) Yao-Xin Lin et al.   Science Translational Medicine

From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape

(2021) Chiranjib Chakraborty et al.   Frontiers in Immunology

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Emerging role and promise of nanomaterials in organoid research

(2021) Chinmaya Mahapatra et al.   DRUG DISCOVERY TODAY

An ionizable lipid toolbox for RNA delivery

(2021) Xuexiang Han et al.   Nature Communications

Hyperthermia and smart drug delivery systems for solid tumor therapy

(2020) A.L.B. Seynhaeve et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications

(2020) Shoaib Iqbal et al.   BIOMACROMOLECULES

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles

(2020) Parikshit Moitra et al.   ACS Nano

Combating Glioblastoma by Codelivering the Small-Molecule Inhibitor of STAT3 and STAT3siRNA with α5β1 Integrin Receptor-Selective Liposomes

(2020) Venugopal Vangala et al.   MOLECULAR PHARMACEUTICS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

(2020) David C. Luther et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymeric vehicles for nucleic acid delivery

(2020) Alexandra S. Piotrowski-Daspit et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid nanoparticle technology for therapeutic gene regulation in the liver

(2020) Dominik Witzigmann et al.   ADVANCED DRUG DELIVERY REVIEWS

Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression

(2020) Mao-Ze Wang et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

(2020) Alexandre J. Debacker et al.   MOLECULAR THERAPY

Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy

(2020) Aniket Wahane et al.   MOLECULES

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

(2020) Paul F. McKay et al.   Nature Communications

MOF-encapsulated nanozyme enhanced siRNA combo: Control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model

(2020) Dongqin Yu et al.   BIOMATERIALS

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

(2020) Mohammad Ariful Islam et al.   BIOMATERIALS

Multifaceted targeting of cationic liposomes via co-delivery of anti-IL-17 siRNA and corticosteroid for topical treatment of psoriasis

(2020) Krishna Yadav et al.   MEDICAL HYPOTHESES

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

(2020) N. N. Parayath et al.   Nature Communications

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

(2019) Susannah L. Hewitt et al.   Science Translational Medicine

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

(2019) Hong-Xia Zhang et al.   MOLECULAR THERAPY

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

(2019) Giulietta Maruggi et al.   MOLECULAR THERAPY

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Exploration of the nanomedicine-design space with high-throughput screening and machine learning

(2019) Gokay Yamankurt et al.   Nature Biomedical Engineering

Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment

(2019) Patricia Mora-Raimundo et al.   ACS Nano

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

(2019) Nathan D. Donahue et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticles for Nucleic Acid Delivery: Applications in Cancer Immunotherapy

(2019) Alvin J. Mukalel et al.   CANCER LETTERS

What Does Nanoparticle Stability Mean?

(2019) Hoa T Phan et al.   Journal of Physical Chemistry C

Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications

(2019) Raj Rai et al.   Polymers

Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

(2019) Hannah J. Vaughan et al.   ADVANCED MATERIALS

Characterizing the protein corona of sub-10 nm nanoparticles

(2019) Dylan Glancy et al.   JOURNAL OF CONTROLLED RELEASE

On the issue of transparency and reproducibility in nanomedicine

(2019) Hon S. Leong et al.   Nature Nanotechnology

Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates

(2019) Koita Sacko et al.   Nanomaterials

Nanoparticle Characterization: Nanoparticle Characterization: What to Measure? (Adv. Mater. 32/2019)

(2019) Mario M. Modena et al.   ADVANCED MATERIALS

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

(2019) María Izco et al.   MOLECULAR THERAPY

Computational design of three-dimensional RNA structure and function

(2019) Joseph D. Yesselman et al.   Nature Nanotechnology

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

(2019) João Conniot et al.   Nature Nanotechnology

Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels

(2019) Mark A. Skylar-Scott et al.   Science Advances

Rational designs of in vivo CRISPR-Cas delivery systems

(2019) Cong-Fei Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA delivery biomaterials for the treatment of genetic and rare diseases

(2019) Weiyu Zhao et al.   BIOMATERIALS

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening

(2019) Pedro P.G. Guimaraes et al.   JOURNAL OF CONTROLLED RELEASE

Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration

(2019) Vasyl Sava et al.   Nanomedicine-Nanotechnology Biology and Medicine

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

(2018) Kalina Paunovska et al.   ACS Nano

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Spherical Nucleic Acid Nanoparticles: Therapeutic Potential

(2018) Chintan H. Kapadia et al.   BIODRUGS

Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment

(2018) Xiao Zhao et al.   BIOMATERIALS

Nanostructured lipid carriers for improved oral delivery and prolonged antihyperlipidemic effect of simvastatin

(2018) Heba A. Fathi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis

(2018) Krishna Yadav et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Co-delivery of resveratrol and p53 gene via peptide cationic liposomal nanocarrier for the synergistic treatment of cervical cancer and breast cancer cells

(2018) Xiaodong Xu et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Gene therapy clinical trials worldwide to 2017: An update

(2018) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

The Effect of Size and Shape of RNA Nanoparticles on Biodistribution

(2018) Daniel L. Jasinski et al.   MOLECULAR THERAPY

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties

(2018) Stefanos Mourdikoudis et al.   Nanoscale

Quantitative self-assembly prediction yields targeted nanomedicines

(2018) Yosi Shamay et al.   NATURE MATERIALS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

Design of Polymeric Gene Carriers for Effective Intracellular Delivery

(2018) Wing-Fu Lai et al.   TRENDS IN BIOTECHNOLOGY

Minimum information reporting in bio–nano experimental literature

(2018) Matthew Faria et al.   Nature Nanotechnology

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening

(2018) Alexandra G. Orlandini von Niessen et al.   MOLECULAR THERAPY

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innovations in gene and growth factor delivery systems for diabetic wound healing

(2017) Ashang Luwang Laiva et al.   Journal of Tissue Engineering and Regenerative Medicine

PEO-b-PCL-b-PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane

(2017) Evgeniia V. Konishcheva et al.   MACROMOLECULES

Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

(2017) Yating Sun et al.   MOLECULES

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

(2017) Livia Palmerston Mendes et al.   MOLECULES

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Evolution of the nanoparticle corona

(2017) Marilena Hadjidemetriou et al.   Nature Nanotechnology

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases

(2017) Davide Prosperi et al.   SEMINARS IN IMMUNOLOGY

The complexity and cost of vaccine manufacturing – An overview

(2017) Stanley Plotkin et al.   VACCINE

Stimuli-responsive liposomes for drug delivery

(2017) Y. Lee et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Surface Charge Controls the Suborgan Biodistributions of Gold Nanoparticles

(2016) Sukru Gokhan Elci et al.   ACS Nano

Clinical Impact of Laboratory Implementation of Verigene BC-GN Microarray-Based Assay for Detection of Gram-Negative Bacteria in Positive Blood Cultures

(2016) Tamar Walker et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

(2016) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Mapping of Molecular Structure of the Nanoscale Surface in Bionanoparticles

(2016) Luciana M. Herda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

(2016) João Conde et al.   NATURE MATERIALS

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

DNA-controlled dynamic colloidal nanoparticle systems for mediating cellular interaction

(2016) S. Ohta et al.   SCIENCE

Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors

(2016) Andrew B. Hill et al.   TRENDS IN BIOTECHNOLOGY

Cryo-electron microscopy and cryo-electron tomography of nanoparticles

(2016) Phoebe L. Stewart   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Local microRNA delivery targets Palladin and prevents metastatic breast cancer

(2016) Avital Gilam et al.   Nature Communications

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

(2016) Miriam Colombo et al.   Nature Communications

Nanoparticle delivery systems for siRNA-based therapeutics

(2016) Jinming Li et al.   Journal of Materials Chemistry B

Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA

(2015) Corey J. Bishop et al.   Acta Biomaterialia

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

(2015) Sara Salatin et al.   CELL BIOLOGY INTERNATIONAL

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

(2015) Hamed Arami et al.   CHEMICAL SOCIETY REVIEWS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment

(2015) João Conde et al.   NATURE MATERIALS

Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting

(2014) Qin Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors

(2014) Arun K. Iyer et al.   MOLECULAR PHARMACEUTICS

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

Multifunctional nanoparticles for brain tumor imaging and therapy

(2013) Yu Cheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis and surface modification of mesoporous silica nanoparticles and its application as carriers for sustained drug delivery

(2013) Ebrahim Ahmadi et al.   DRUG DELIVERY

Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

(2013) Charles H. Jones et al.   MOLECULAR PHARMACEUTICS

Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery

(2013) Shan Jiang et al.   NANO LETTERS

Current trends in the use of liposomes for tumor targeting

(2013) Pranali P Deshpande et al.   Nanomedicine

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Peptide Vectors for the Nonviral Delivery of Nucleic Acids

(2012) Jan Hoyer et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging

(2012) Sjoerd Hak et al.   ACS Nano

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Simplifying the synthesis of dendrimers: accelerated approaches

(2012) Marie V. Walter et al.   CHEMICAL SOCIETY REVIEWS

Targeted Polymersome Delivery of siRNA Induces Cell Death of Breast Cancer Cells Dependent upon Orai3 Protein Expression

(2012) Todd O. Pangburn et al.   LANGMUIR

Focusing the research efforts

(2012) Françoise Schrurs et al.   Nature Nanotechnology

Nanoparticle ζ -Potentials

(2011) Tennyson L. Doane et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery

(2010) Shaoheng Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Background, status and future of the Transmission Electron Aberration-corrected Microscope project

(2009) U. Dahmen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES