Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Tumor mutational burden and PTEN alterations as molecular correlates of response to PD-1/L1 blockade in metastatic triple-negative breast cancer

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Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

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Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy

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Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

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Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

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Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer

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Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer

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CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy

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Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

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Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

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In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

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Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System

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Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma

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Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer

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Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients

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Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

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Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

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Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

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Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency

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Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

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Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

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pH-Sensitive Polymeric Nanoparticles Modulate Autophagic Effect via Lysosome Impairment

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Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer

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Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90

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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

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The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

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PTEN: Multiple Functions in Human Malignant Tumors

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Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity

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Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

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Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival

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