Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation

(2018) Shufang He et al.   NANO LETTERS

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival

(2018) Hernando Lopez-Bertoni et al.   NANO LETTERS

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

(2018) David R. Wilson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery

(2018) Barry A. Badeau et al.   Nature Chemistry

Spray-Dried Nanoparticle-in-Microparticle Delivery Systems (NiMDS) for Gene Delivery, Comprising Polyethylenimine (PEI)-Based Nanoparticles in a Poly(Vinyl Alcohol) Matrix

(2018) Jan Schulze et al.   Small

A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells

(2018) Haoran Liu et al.   Theranostics

Synthesis and Characterization of Quaternized Poly(β-amino ester) for Highly Efficient Delivery of Small Interfering RNA

(2018) Yun Liu et al.   MOLECULAR PHARMACEUTICS

Non-Viral Delivery To Enable Genome Editing

(2018) Yuan Rui et al.   TRENDS IN BIOTECHNOLOGY

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

Multifunctional Vector for Delivery of Genome Editing Plasmid Targeting β-Catenin to Remodulate Cancer Cell Properties

(2018) Xiao-Yan He et al.   ACS Applied Materials & Interfaces

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantum dots in imaging, drug delivery and sensor applications

(2017) Cristian Matea et al.   International Journal of Nanomedicine

Continuous microfluidic assembly of biodegradable poly(beta-amino ester)/DNA nanoparticles for enhanced gene delivery

(2017) David R. Wilson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Versatile modes of cellular regulation via cyclic dinucleotides

(2017) Petya Violinova Krasteva et al.   Nature Chemical Biology

Delivery technologies for genome editing

(2017) Hao Yin et al.   NATURE REVIEWS DRUG DISCOVERY

Unveiling the impact of nanoparticle size dispersity on the behavior of polymer nanocomposites

(2017) J. Javier Burgos-Mármol et al.   POLYMER

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

(2017) James E. Dahlman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy

(2017) Yi Jin et al.   NPG Asia Materials

Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy

(2016) Jayoung Kim et al.   Acta Biomaterialia

Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer

(2016) Dunwan Zhu et al.   Acta Biomaterialia

Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting

(2016) Hui Li et al.   ADVANCED MATERIALS

Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

(2016) Huiping Sun et al.   ADVANCED MATERIALS

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Overexpression of caveolin-1 in inflammatory breast cancer cells enables IBC-specific gene delivery and prodrug conversion using histone-targeted polyplexes

(2016) Nikki L. Ross et al.   BIOTECHNOLOGY AND BIOENGINEERING

Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors

(2016) D. D. Von Hoff et al.   CLINICAL CANCER RESEARCH

Correlation between cationic lipid-based transfection and cell division

(2016) Inka Kirchenbuechler et al.   EXPERIMENTAL CELL RESEARCH

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

(2016) Carla L. Esposito et al.   JOURNAL OF CONTROLLED RELEASE

Engineering biodegradable micelles of polyethylenimine-based amphiphilic block copolymers for efficient DNA and siRNA delivery

(2016) Weiwei Wang et al.   JOURNAL OF CONTROLLED RELEASE

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Design of Ionizable Lipids To Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA

(2016) Damien Habrant et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

(2016) Katherine E. Bujold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

(2016) A Michael Lincoff et al.   LANCET

Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells

(2016) Emiliano Cocco et al.   MOLECULAR CANCER THERAPEUTICS

Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA

(2016) Yingying Xu et al.   MOLECULAR PHARMACEUTICS

Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

(2016) João Conde et al.   NATURE MATERIALS

Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release

(2016) Zhen Fan et al.   Nature Nanotechnology

Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery

(2016) Xinyi Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addressing intra-tumoral heterogeneity and therapy resistance

(2016) Brad Rybinski et al.   Oncotarget

Gold Nanoparticle–Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy

(2016) Wei Li et al.   Scientific Reports

The Development of a Viral Mediated CRISPR/Cas9 System with Doxycycline Dependent gRNA Expression for Inducible In vitro and In vivo Genome Editing

(2016) Christopher A. de Solis et al.   Frontiers in Molecular Neuroscience

Multifunctional Poly(l-lactide)–Polyethylene Glycol-Grafted Graphene Quantum Dots for Intracellular MicroRNA Imaging and Combined Specific-Gene-Targeting Agents Delivery for Improved Therapeutics

(2015) Haifeng Dong et al.   ACS Applied Materials & Interfaces

Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA

(2015) Corey J. Bishop et al.   Acta Biomaterialia

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Non-viral Delivery Systems for the Application in p53 Cancer Gene Therapy

(2015) Kai Wang et al.   CURRENT MEDICINAL CHEMISTRY

Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy

(2015) Hyewon Youn et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Adenovirus-Mediated Somatic Genome Editing ofPtenby CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

(2015) Dan Wang et al.   HUMAN GENE THERAPY

Nanobody-based cancer therapy of solid tumors

(2015) Marta Kijanka et al.   Nanomedicine

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Ets1 identified as a novel molecular target of RNA aptamer selected against metastatic cells for targeted delivery of nano-formulation

(2015) J Kaur et al.   ONCOGENE

Overcoming Multiple Drug Resistance by Spatial-Temporal Synchronization of Epirubicin and Pooled siRNAs

(2015) Wei Chen et al.   Small

Cancer nanomedicine: from targeted delivery to combination therapy

(2015) Xiaoyang Xu et al.   TRENDS IN MOLECULAR MEDICINE

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

(2015) Eric W F W Alton et al.   Lancet Respiratory Medicine

Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer

(2014) Jong-Min Lim et al.   ACS Nano

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

CRISPR/Cas9-mediated genome engineering: An adeno-associated viral (AAV) vector toolbox

(2014) Elena Senís et al.   Biotechnology Journal

The importance of nanoparticle shape in cancer drug delivery

(2014) Nghia P Truong et al.   Expert Opinion on Drug Delivery

Cancer active targeting by nanoparticles: a comprehensive review of literature

(2014) Remon Bazak et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Gold Nanoparticles for Nucleic Acid Delivery

(2014) Ya Ding et al.   MOLECULAR THERAPY

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine

(2014) Hui Yi Xue et al.   Nanomedicine

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer

(2014) A L Kasinski et al.   ONCOGENE

Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

(2014) René Rietscher et al.   PHARMACEUTICAL RESEARCH

Small RNA combination therapy for lung cancer

(2014) W. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Role of integrated cancer nanomedicine in overcoming drug resistance

(2013) Arun K. Iyer et al.   ADVANCED DRUG DELIVERY REVIEWS

Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures

(2013) Jiang Li et al.   ADVANCED MATERIALS

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors

(2013) Hiroto Hatakeyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Folic Acid Modified Cationic γ-Cyclodextrin-oligoethylenimine Star Polymer with Bioreducible Disulfide Linker for Efficient Targeted Gene Delivery

(2013) Feng Zhao et al.   BIOMACROMOLECULES

SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

(2013) Ching-Hsiang Fan et al.   BIOMATERIALS

A review of the current status of siRNA nanomedicines in the treatment of cancer

(2013) Pauline Resnier et al.   BIOMATERIALS

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors

(2013) Shanthi Ganesh et al.   BIOMATERIALS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Inhibition of hepatic fibrosis with artificial microRNA using ultrasound and cationic liposome-bearing microbubbles

(2013) D Yang et al.   GENE THERAPY

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

(2013) Jonathan E. Rosenberg et al.   INVESTIGATIONAL NEW DRUGS

Polyplex Exposure Inhibits Cell Cycle, Increases Inflammatory Response, and Can Cause Protein Expression without Cell Division

(2013) Rebecca L. Matz et al.   MOLECULAR PHARMACEUTICS

Oscillating magnet array-based nanomagnetic gene transfection of human mesenchymal stem cells

(2013) Angeliki Fouriki et al.   Nanomedicine

Lipid-based nanoparticles in the systemic delivery of siRNA

(2013) Qiaoya Lin et al.   Nanomedicine

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Coarse-graining DNA for simulations of DNA nanotechnology

(2013) Jonathan P. K. Doye et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

(2013) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Interference Functions as an Antiviral Immunity Mechanism in Mammals

(2013) Y. Li et al.   SCIENCE

TRAIL on trial: preclinical advances in cancer therapy

(2013) Daniel W. Stuckey et al.   TRENDS IN MOLECULAR MEDICINE

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer (Adv. Healthcare Mater. 3/2013)

(2013) Stephany Y. Tzeng et al.   Advanced Healthcare Materials

 v Integrins in Angiogenesis and Cancer

(2013) S. M. Weis et al.   Cold Spring Harbor Perspectives in Medicine

Surface modification of TPGS-b-(PCL-ran-PGA) nanoparticles with polyethyleneimine as a co-delivery system of TRAIL and endostatin for cervical cancer gene therapy

(2013) Yi Zheng et al.   Nanoscale Research Letters

Combination of siRNA-directed Gene Silencing With Cisplatin Reverses Drug Resistance in Human Non-small Cell Lung Cancer

(2013) Shanthi Ganesh et al.   Molecular Therapy-Nucleic Acids

Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection

(2012) Zeyu Xiao et al.   ACS Nano

Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells

(2012) Wanisa Punfa et al.   ACTA PHARMACOLOGICA SINICA

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

(2012) You-Yong Yuan et al.   ADVANCED MATERIALS

Nanoparticle-based combination therapy toward overcoming drug resistance in cancer

(2012) Che-Ming Jack Hu et al.   BIOCHEMICAL PHARMACOLOGY

Gene and doxorubicin co-delivery system for targeting therapy of glioma

(2012) Shuhuan Liu et al.   BIOMATERIALS

Overcoming multidrug resistance by co-delivery of Mdr-1 and survivin-targeting RNA with reduction-responsible cationic poly(β-amino esters)

(2012) Qi Yin et al.   BIOMATERIALS

Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation

(2012) Stephany Y. Tzeng et al.   BIOMATERIALS

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

(2012) Julien Nicolas et al.   CHEMICAL SOCIETY REVIEWS

Radiolabelled RGD peptides for imaging and therapy

(2012) F. C. Gaertner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics

(2012) Stephanie D. Steichen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle Delivery of Pooled siRNA for Effective Treatment of Non-Small Cell Lung Caner

(2012) Yang Yang et al.   MOLECULAR PHARMACEUTICS

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

(2012) Fabienne Danhier et al.   MOLECULAR PHARMACEUTICS

Hollow Spherical Nucleic Acids for Intracellular Gene Regulation Based upon Biocompatible Silica Shells

(2012) Kaylie L. Young et al.   NANO LETTERS

Effect of ligand density, receptor density, and nanoparticle size on cell targeting

(2012) Drew R. Elias et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

(2012) Meihua Yu et al.   Nanoscale

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combination therapy with VEGFR2 and EGFR siRNA enhances the antitumor effect of cisplatin in non-small cell lung cancer xenografts

(2012) SHAN CHEN et al.   ONCOLOGY REPORTS

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Bioreducible Polymers for Gene Silencing and Delivery

(2011) Sejin Son et al.   ACCOUNTS OF CHEMICAL RESEARCH

A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial

(2011) Thomas J. Povsic et al.   AMERICAN HEART JOURNAL

In Vivo Delivery of RNAi with Lipid-Based Nanoparticles

(2011) Leaf Huang et al.   Annual Review of Biomedical Engineering

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Glycans as cancer biomarkers

(2011) Barbara Adamczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity

(2011) Frederico Pittella et al.   BIOMATERIALS

Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides

(2011) Jingwei Li et al.   BIOMATERIALS

Sustained local delivery of siRNA from an injectable scaffold

(2011) Christopher E. Nelson et al.   BIOMATERIALS

Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors

(2011) Jiangbing Zhou et al.   BIOMATERIALS

Plasmid DNA-loaded chitosan/TPP nanoparticles for topical gene delivery

(2011) Suna Özbaş-Turan et al.   DRUG DELIVERY

Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery

(2011) Yuguo Lei et al.   JOURNAL OF CONTROLLED RELEASE

Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors

(2011) Shashank R. Sirsi et al.   JOURNAL OF CONTROLLED RELEASE

Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers

(2011) Jesse B. Wolinsky et al.   JOURNAL OF CONTROLLED RELEASE

Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA

(2011) Oleh Taratula et al.   JOURNAL OF DRUG TARGETING

Intrinsic Heterogeneity in Liposome Suspensions Caused by the Dynamic Spontaneous Formation of Hydrophobic Active Sites in Lipid Membranes

(2011) Víctor Agmo Hernández et al.   LANGMUIR

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s

(2011) Pieter Vader et al.   PHARMACEUTICAL RESEARCH

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

(2011) Tanya Stuchinskaya et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

N-Alkyl-PEI-Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery

(2011) Gang Liu et al.   Small

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma

(2010) Hiroto Hatakeyama et al.   ADVANCED DRUG DELIVERY REVIEWS

Folic Acid-Conjugated Chitosan Nanoparticles Enhanced Protoporphyrin IX Accumulation in Colorectal Cancer Cells

(2010) Shu-Jyuan Yang et al.   BIOCONJUGATE CHEMISTRY

Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds

(2010) Yuguo Lei et al.   BIOMATERIALS

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

Cyclodextrin-based gene delivery systems

(2010) Carmen Ortiz Mellet et al.   CHEMICAL SOCIETY REVIEWS

Sequential treatment of drug-resistant tumors with RGD-modified liposomes containing siRNA or doxorubicin

(2010) Juan Jiang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery

(2010) Yuhan Lee et al.   JOURNAL OF CONTROLLED RELEASE

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

(2010) John R Hornick et al.   Molecular Cancer

Nanoparticulate drug delivery systems for cancer chemotherapy

(2010) Ranendra N. Saha et al.   MOLECULAR MEMBRANE BIOLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived mesenchymal stem cells against experimental brainstem glioma

(2010) S. A. Choi et al.   NEURO-ONCOLOGY

Topical Application of Antisense Oligonucleotide-Loaded Chitosan Nanoparticles to Rats

(2010) Suna Özbaş-Turan et al.   OLIGONUCLEOTIDES

Targeted hepatocellular carcinoma proapoptotic BikDD gene therapy

(2010) L-Y Li et al.   ONCOGENE

The Development and Mechanism Studies of Cationic Chitosan-Modified Biodegradable PLGA Nanoparticles for Efficient siRNA Drug Delivery

(2010) Xudong Yuan et al.   PHARMACEUTICAL RESEARCH

Adnectins: engineered target-binding protein therapeutics

(2010) D. Lipovsek   PROTEIN ENGINEERING DESIGN & SELECTION

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection

(2009) Forrest M. Kievit et al.   ADVANCED FUNCTIONAL MATERIALS

Aptamer−Nanoparticle Strip Biosensor for Sensitive Detection of Cancer Cells

(2009) Guodong Liu et al.   ANALYTICAL CHEMISTRY

Tissue-specific gene delivery via nanoparticle coating

(2009) Todd J. Harris et al.   BIOMATERIALS

Self-assembled hyaluronic acid nanoparticles for active tumor targeting

(2009) Ki Young Choi et al.   BIOMATERIALS

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

(2009) Frederic Heitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Preclinical Evaluation of Novel Glutamate-Urea-Lysine Analogues That Target Prostate-Specific Membrane Antigen as Molecular Imaging Pharmaceuticals for Prostate Cancer

(2009) S. M. Hillier et al.   CANCER RESEARCH

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dendrimers: Emerging polymers for drug-delivery systems

(2009) Basavaraj K. Nanjwade et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Degradable polyethylenimines as DNA and small interfering RNA carriers

(2009) D Jere et al.   Expert Opinion on Drug Delivery

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

(2009) Hiroto Hatakeyama et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

The forthcoming applications of gold nanoparticles in drug and gene delivery systems

(2009) Dakrong Pissuwan et al.   JOURNAL OF CONTROLLED RELEASE

Lipid-based nanotherapeutics for siRNA delivery

(2009) A. Schroeder et al.   JOURNAL OF INTERNAL MEDICINE

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

(2009) James J. Lu et al.   MOLECULAR PHARMACEUTICS

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

(2009) Anekant Jain et al.   Nanomedicine-Nanotechnology Biology and Medicine

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

(2009) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Intelligent nucleic acid delivery systems based on stimuli-responsive polymers

(2009) Fu-Sheng Du et al.   Soft Matter

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

(2008) Jordan J. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Microbubbles in ultrasound-triggered drug and gene delivery

(2008) Sophie Hernot et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis and Modification of Functional Poly(lactide) Copolymers: Toward Biofunctional Materials

(2008) David E. Noga et al.   BIOMACROMOLECULES

Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells

(2008) Sunita Yadav et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cancer and the tumor microenvironment: a review of an essential relationship

(2008) Flaubert Mbeunkui et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo

(2008) Olga V. Chumakova et al.   CANCER LETTERS

Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

(2008) Andrew Z. Wang et al.   ChemMedChem

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo

(2008) S. Oliveira et al.   CURRENT PHARMACEUTICAL DESIGN

Studies on bioadhesive PLGA nanoparticles: A promising gene delivery system for efficient gene therapy to lung cancer

(2008) Weiwei Zou et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A Series of Halogenated Heterodimeric Inhibitors of Prostate Specific Membrane Antigen (PSMA) as Radiolabeled Probes for Targeting Prostate Cancer

(2008) K. P. Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Breathing Life into Polycations:  Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery

(2008) Martin Meyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantifying Nanoparticle Adhesion Mediated by Specific Molecular Interactions

(2008) Jered B. Haun et al.   LANGMUIR

DNAzyme technology and cancer therapy: cleave and let die

(2008) C. R. Dass et al.   MOLECULAR CANCER THERAPEUTICS

Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer

(2008) Maha Saad et al.   Nanomedicine

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties

(2008) S Kumar et al.   Nature Protocols

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging

(2008) Lily Yang et al.   Small

Nanotechnology and aptamers: applications in drug delivery

(2008) Etgar Levy-Nissenbaum et al.   TRENDS IN BIOTECHNOLOGY

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

Cell-Specific Internalization Study of an Aptamer from Whole Cell Selection

(2007) Zeyu Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tumor-targeted Delivery of siRNA by Self-assembled Nanoparticles

(2007) Shyh-Dar Li et al.   MOLECULAR THERAPY