Multi-Faceted Roles of DNAJB Protein in Cancer Metastasis and Clinical Implications

DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer

(2022) Zheng Wang et al.   Cell Death & Disease

Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway

(2022) Peng Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1

(2021) Hye-Youn Kim et al.   Cell Death & Disease

Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer

(2021) Quanyu Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DNAJB11 predicts a poor prognosis and is associated with immune infiltration in thyroid carcinoma: a bioinformatics analysis

(2021) Rongxin Sun et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3p

(2020) Pei Ma et al.   OncoTargets and Therapy

Dnajb8, a target gene of SOX30, is dispensable for male fertility in mice

(2020) Fengsong Wang et al.   PeerJ

Systems-level analysis reveals multiple modulators of epithelial-mesenchymal transition and identifies DNAJB4 and CD81 as novel metastasis inducers in breast cancer

(2019) Zeynep Cansu Uretmen Kagiali et al.   MOLECULAR & CELLULAR PROTEOMICS

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

(2019) Yunjie Huang et al.   Scientific Reports

The Complex Phosphorylation Patterns that Regulate the Activity of Hsp70 and Its Cochaperones

(2019) Velasco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis

(2019) Shaoshan Yang et al.   ONCOGENE

Heat-shock proteins: chaperoning DNA repair

(2019) Laurence Dubrez et al.   ONCOGENE

Physiological functions of heat shock proteins

(2019) Qiang Shan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia

(2019) Dan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

(2019) Chul Won Yun et al.   Cells

Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1

(2018) Hiroki Kusumoto et al.   CANCER SCIENCE

The endoplasmic reticulum co-chaperone ERdj3/DNAJB11 promotes hepatocellular carcinoma progression through suppressing AATZ degradation

(2018) Junjiang Pan et al.   Future Oncology

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3

(2018) Bernd O. Evert et al.   PLoS One

PTMD: A Database of Human Disease-associated Post-translational Modifications

(2018) Haodong Xu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Endoplasmic reticulum stress–induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis

(2017) Pattarawut Sopha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation

(2017) Nazli Khodayari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNAJB1–PRKACAfusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

(2017) Edward R. Kastenhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

(2017) Zuzanna Tracz-Gaszewska et al.   Oncotarget

Comparison of the glycopattern alterations of mitochondrial proteins in cerebral cortex between rat Alzheimer’s disease and the cerebral ischemia model

(2017) Houyou Yu et al.   Scientific Reports

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms

(2016) C-H Chen et al.   ONCOGENE

Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response

(2016) Masamichi Yamashita et al.   PLoS One

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1

(2016) Shahid Y. Khan et al.   Nature Communications

Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins

(2016) Jyoti Batra et al.   Scientific Reports

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

(2016) Mark R. Woodford et al.   Cell Reports

Protein Glycosylation in Cancer

(2015) Sean R. Stowell et al.   Annual Review of Pathology-Mechanisms of Disease

DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling

(2015) Soo-Yeon Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Towards the computational design of protein post-translational regulation

(2015) Marta Strumillo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis

(2015) Xiandan Cui et al.   CANCER LETTERS

Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells

(2015) Valen Zhuoyou Yu et al.   GASTROENTEROLOGY

A novel method for predicting post-translational modifications on serine and threonine sites by using site-modification network profiles

(2015) Minghui Wang et al.   Molecular BioSystems

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor

(2014) Yuli Lin et al.   BMC CANCER

Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells

(2014) Rena Morita et al.   CANCER SCIENCE

Biomechanical characterization of myofibrillar myopathies

(2014) Lilli Winter et al.   CELL BIOLOGY INTERNATIONAL

Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53

(2014) H J Lee et al.   CELL DEATH AND DIFFERENTIATION

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis

(2014) J. C. Genereux et al.   EMBO JOURNAL

Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway

(2014) Tong-Tong Zhang et al.   MOLECULAR CARCINOGENESIS

Epithelial-to-Mesenchymal Transition Activates PERK-eIF2  and Sensitizes Cells to Endoplasmic Reticulum Stress

(2014) Y.-x. Feng et al.   Cancer Discovery

Proteomics of protein post-translational modifications implicated in neurodegeneration

(2014) Ru-Jing Ren et al.   Translational Neurodegeneration

Increased Expression of Endoplasmic Reticulum Stress and Unfolded Protein Response Genes in Peripheral Blood Mononuclear Cells From Patients With Limited Cutaneous Systemic Sclerosis and Pulmonary Arterial Hypertension

(2013) Stefania Lenna et al.   ARTHRITIS AND RHEUMATISM

DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner

(2013) Min Qi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The HLJ1 -targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer

(2013) Yi-Hua Lai et al.   CARCINOGENESIS

Phosphorylation of heat shock protein 40 (Hsp40/DnaJB1) by mitogen-activated protein kinase-activated protein kinase 5 (MK5/PRAK)

(2013) Sergiy Kostenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ

(2012) Joel A. Cassel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem-like Cells

(2012) S. Nishizawa et al.   CANCER RESEARCH

CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression

(2012) Andrew W. Truman et al.   CELL

Micro-RNA-632 downregulates DNAJB6 in breast cancer

(2012) Aparna Mitra et al.   LABORATORY INVESTIGATION

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy

(2012) Jaakko Sarparanta et al.   NATURE GENETICS

DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin

(2012) A Mitra et al.   ONCOGENE

Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy

(2011) Matthew B. Harms et al.   ANNALS OF NEUROLOGY

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells

(2011) Joy X Lei et al.   Molecular Neurodegeneration

Toward understanding Machado–Joseph disease

(2011) Maria do Carmo Costa et al.   PROGRESS IN NEUROBIOLOGY

Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells

(2011) Lei Zhang et al.   VIRUS RESEARCH

The Role of NF-κB in Hepatitis B Virus X Protein-Mediated Upregulation of VEGF and MMPs

(2010) Li-ping Liu et al.   CANCER INVESTIGATION

Modeling general proteostasis: proteome balance in health and disease

(2010) Daniela M Roth et al.   CURRENT OPINION IN CELL BIOLOGY

DNAJB6 Induces Degradation of β-Catenin and Causes Partial Reversal of Mesenchymal Phenotype

(2010) Aparna Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ER-membrane-resident Hsp40 ERj1 is a novel substrate for protein kinase CK2

(2009) Claudia Götz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors

(2009) Vinoth Babu V. Rajan et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1

(2008) H.-W. Chen et al.   CANCER RESEARCH

Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library

(2008) Jurre Hageman et al.   CELL STRESS & CHAPERONES