DNAJB1–PRKACAfusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1 – Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

(2017) Lars H. Engelholm et al.   GASTROENTEROLOGY

Environmental exposures as a risk factor for fibrolamellar carcinoma

(2017) Rondell P Graham et al.   MODERN PATHOLOGY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Transposons As Tools for Functional Genomics in Vertebrate Models

(2017) Koichi Kawakami et al.   TRENDS IN GENETICS

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

(2017) Teng Han et al.   Nature Communications

Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

(2017) Peter J. Cook et al.   Nature Communications

Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma

(2017) Timothy A. Dinh et al.   Scientific Reports

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology

(2016) Rigney E. Turnham et al.   GENE

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

(2016) Matthias S. Matter et al.   HEPATOLOGY

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

(2016) Yu Liu et al.   NATURE

Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma

(2016) Kevin M. Riggle et al.   PEDIATRIC BLOOD & CANCER

Unique Genomic Profile of Fibrolamellar Hepatocellular Carcinoma

(2015) Helena Cornella et al.   GASTROENTEROLOGY

DNAJB1-PRKACA is specific for fibrolamellar carcinoma

(2015) Rondell P Graham et al.   MODERN PATHOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Transcriptomic characterization of fibrolamellar hepatocellular carcinoma

(2015) Elana P. Simon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells

(2015) Tsunekazu Oikawa et al.   Nature Communications

The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients

(2015) David G. Darcy et al.   Oncotarget

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

(2014) Darjus F. Tschaharganeh et al.   CELL

mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma

(2014) Kimberly J Riehle et al.   MODERN PATHOLOGY

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

(2014) Danilo Maddalo et al.   NATURE

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

Targeted genomic rearrangements using CRISPR/Cas technology

(2014) Peter S. Choi et al.   Nature Communications

Simple and Rapid In Vivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology

(2014) Rafael B. Blasco et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Molecular chaperones as enzymes that catalytically unfold misfolded polypeptides

(2013) Smriti Priya et al.   FEBS LETTERS

Wnt/β-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3

(2013) Guo-Zhong Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Prognostic Indicators and Treatment Outcome in 94 Cases of Fibrolamellar Hepatocellular Carcinoma

(2013) Ahmed O. Kaseb et al.   ONCOLOGY

Fibrolamellar hepatocellular carcinoma in the USA, 2000–2010: A detailed report on frequency, treatment and outcome based on the Surveillance, Epidemiology, and End Results database

(2013) Tobias Eggert et al.   United European Gastroenterology Journal

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts

(2012) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial accumulation under oxidative stress is due to defects in autophagy

(2012) Cheng Luo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

 -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

(2011) W. van Veelen et al.   GUT

Fibrolamellar carcinomas are positive for CD68

(2010) Hillary M Ross et al.   MODERN PATHOLOGY

Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation

(2010) Stephen C Ward et al.   MODERN PATHOLOGY

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene

(2008) Benjamin Cieply et al.   HEPATOLOGY

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis

(2008) Shelly Beer et al.   PLoS One