Article
Endocrinology & Metabolism
Shun Bai, Meihong Hu, Lina Yu, Linjun Chen, Jidong Zhou, Limin Wu, Bo Xu, Xiaohua Jiang, Xindong Zhang, Xianhong Tong, Qiuling Yue
Summary: Background: DNAJB7 is a highly conserved protein involved in various biological processes. However, its function in spermatogenesis and male fertility has been unclear. Methods: Dnajb7-deficient mice were generated using CRISPR/Cas9-mediated genome editing system to investigate the role of DNAJB7 in male reproduction. Results: DNAJB7 is specifically expressed in haploid germ cells. Dnajb7 knockout mice are fertile and show no defects in Sertoli cells, spermatogonia, meiotic and postmeiotic cells, suggesting that DNAJB7 is not essential for spermatogenesis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
XueXia Liu, ZhiXin Wang, Fujun Liu
Summary: Mice treated with BPA exhibited decreased sperm quality, lower serum testosterone levels, and a sub-fertile phenotype, mainly due to impaired germ cell proliferation. BPA had a concentration-dependent inhibition effect on germ cell proliferation, leading to reduced male fertility.
Article
Biochemistry & Molecular Biology
Jinmei Li, Shenglei Feng, Xixiang Ma, Shuiqiao Yuan, Xiaoli Wang
Summary: In this study, the role of non-histone methyltransferase METTL21A in spermatogenesis was investigated using a global knockout mouse model. The results showed that METTL21A is highly expressed in mouse testes but its ablation does not affect male fertility or the development of male germ cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Qumar Zaman, Ranjha Khan, Uzma Hameed, Wasim Shah, Ahmed Waqas, Muhammad Zubair, Sobia Dil, Tuba Zafar, Asim Ali, Ahsanullah Unar, Qinghua Shi
Summary: The study found that Exo5 knockout mice are fertile despite a slight decrease in sperm count, and showed no remarkable differences in epididymal histology and testis/body weight ratio. Under normal breeding conditions, Exo5 seems to have no essential role in spermatogenesis in mice.
Article
Developmental Biology
Na Liu, Fatimunnisa Qadri, Hauke Busch, Stefanie Huegel, Gabin Sihn, Ilya Chuykin, Enno Hartmann, Michael Bader, Franziska Rother
Summary: The protein Kpna6 plays a crucial role in spermatogenesis and male fertility, with its deficiency leading to infertility and various effects on sperm and Sertoli cells. Its absence results in impaired Sertoli cell function, incomplete sperm maturation, and altered expression of genes involved in sperm production.
Article
Cell Biology
Sara Bilekova, Balma Garcia-Colomer, Alberto Cebrian-Serrano, Silvia Schirge, Karsten Krey, Michael Sterr, Thomas Kurth, Stefanie M. Hauck, Heiko Lickert
Summary: Spermatogenesis is a crucial biological process that produces functional sperm for successful reproduction. The acrosome, a lysosome-related organelle in the sperm head, is essential for egg-sperm recognition and fusion. The role of the insulin inhibitory receptor (inceptor) in acrosome formation was investigated, and its absence resulted in acrosomal malformation and male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Genetics & Heredity
Garett P. Slater, Nicholas M. A. Smith, Brock A. Harpur
Summary: Bees, both managed and native species, are facing increasing pressures from human activities, impacting their fertility. Genetic variation plays a significant role in sperm production, maintenance, and insemination success among males. However, research on male fertility in bees and non-Apis pollinators remains largely understudied.
Review
Biochemistry & Molecular Biology
Gabriella Chieffi Baccari, Giuseppe Iurato, Alessandra Santillo, Brian Dale
Summary: Male infertility is correlated with the shortening of sperm telomeres, which regulate the reproductive lifespan. Telomeres are composed of DNA repeats and are coupled to proteins and RNA. Telomerase activity in male germ cells maintains telomere length during spermatogenesis, despite DNA replication and genotoxic factors. Exposure to pollutants has been associated with male infertility, but few consider telomeric DNA as a parameter for sperm function. This review aims to provide comprehensive data on the structure and function of telomeres in spermatogenesis and the influence of environmental pollutants.
Review
Cell Biology
Mohammed Hoque, Eunice N. Kim, Danny Chen, Feng-Qian Li, Ken-Ichi Takemaru
Summary: Cilia are hair-like organelles on the cell surface that play important roles in various biological processes and their dysfunction can lead to diseases. Multiciliated cells in the male reproductive tract are crucial for male fertility.
Review
Medicine, Research & Experimental
Tahseen S. Sayed, Nafisa H. Balasinor, Kumari Nishi
Summary: The endocannabinoid system plays a significant role in male reproduction, impacting sperm function and male sexual behavior. Dysfunctional ECS is linked to the development of prostate cancer.
Article
Agriculture, Dairy & Animal Science
Yena Jung, Hyewon Bang, Young-Hyun Kim, Na-Eun Park, Young-Ho Park, Chaeli Park, Sang-Rae Lee, Jeong-Woong Lee, Bong-Seok Song, Ji-Su Kim, Bo-Woong Sim, Dong-Won Seol, Gabbine Wee, Sunhyung Kim, Sun-Uk Kim, Ekyune Kim
Summary: The study investigated the functional role of VSIG1 in spermatogenesis and fertilization by knocking out VSIG1 in mouse embryos using CRISPR/Cas9. Results showed that the lack of VSIG1 did not impact spermatogenesis and male fertility in mice, suggesting it may not play essential roles in these processes. Further investigations are needed to understand the importance and molecular mechanism of VSIG1 in tissues of other species.
Letter
Biochemistry & Molecular Biology
Jing Jin, Xiaofeng Li, Mei Ye, Feng Qiao, Hao Chen, Kin Lam Fok
Summary: This study reveals the important role of Defb19 in male fertility, as it regulates the migration of both Sertoli cells and germ cells in the testis.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chunyu Lv, Mengneng Xiong, Shuangshuang Guo, Yiqian Gui, Xiaohua Liu, Xiaoli Wang, Yanqing Wu, Shenglei Feng, Jin Zhang, Yan Zhang, Yu Liu, Weibing Qin, Shuiqiao Yuan
Summary: The study found that the WDFY1 protein is highly expressed in mouse testes and localized in the cytoplasm of late pachytene spermatocytes to elongated spermatids. However, global knockout of the Wdfy1 gene in mice did not affect their growth, development, and fertility, indicating that WDFY1 is dispensable for mouse spermatogenesis and male fertility.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lanying Yang, You Wu, Yun Su, Xuefeng Zhang, Tapas Chakraborty, Deshou Wang, Linyan Zhou
Summary: This study reveals the essentiality of the cyp17a2 gene in the production of cortisol and DHP and its role in meiotic initiation and subfertility. This highlights the importance of DHP and cortisol in male fertility in fish.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Hu-He Chao, Ye Zhang, Pei-Yu Dong, Sangiliyandi Gurunathan, Xi-Feng Zhang
Summary: With the increasing global incidence of infertility, researchers have begun to focus on the impact of environmental factors, lifestyle habits, and nutrients on reproductive health. This review considers the potential role of genetic, environmental, and endocrine factors; nutrients and trace elements in male reproductive health, sperm function, and fertility potency, aiming to provide a theoretical basis for clinical treatment of infertility.
FRONTIERS IN NUTRITION
(2023)
