Heat-shock proteins: chaperoning DNA repair

The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease

(2019) Stuart K. Calderwood et al.   CELL STRESS & CHAPERONES

The Nuclear and DNA-Associated Molecular Chaperone Network

(2019) Zlata Gvozdenov et al.   Cold Spring Harbor Perspectives in Biology

The Molecular Chaperone HSP70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA-Damage and MAPK/ERK Signaling Pathways

(2019) Wonkyoung Cho et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the unfolded protein response via inhibition of protein disulfide isomerase decreases the capacity for DNA repair to sensitize glioblastoma to radiotherapy

(2019) Yajing Liu et al.   CANCER RESEARCH

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

(2019) Gustavo J. Gozzi et al.   CELL DEATH AND DIFFERENTIATION

Tat-HSP70 protects neurons from oxidative damage in the NSC34 cells and ischemic damage in the ventral horn of rabbit spinal cord

(2019) Woosuk Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines

(2019) Eugenia M. Clerico et al.   BIOCHEMICAL JOURNAL

Assembling nuclear domains: Lessons from DNA repair

(2019) Benjamin Schrank et al.   JOURNAL OF CELL BIOLOGY

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy

(2019) Valentina Condelli et al.   Cells

Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer

(2019) Sayan Dutta Gupta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HSP110 sustains chronic NF-κB signaling in activated B cell diffuse large B cell lymphoma through MyD88 stabilization

(2018) Christophe Boudesco et al.   BLOOD

Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion

(2018) Yusuke Yamamoto et al.   BRAIN RESEARCH

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous recombination and the repair of DNA double-strand breaks

(2018) William Douglass Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How cells ensure correct repair of DNA double-strand breaks

(2018) Joonyoung Her et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA mismatch repair in cancer

(2018) Marina Baretti et al.   PHARMACOLOGY & THERAPEUTICS

It’s not magic – Hsp90 and its effects on genetic and epigenetic variation

(2018) Rebecca A. Zabinsky et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An update on the discovery and development of selective heat shock protein inhibitors as anti-cancer therapy

(2018) Fisayo Olotu et al.   Expert Opinion on Drug Discovery

A motif in HSP90 and P23 that links molecular chaperones to efficient estrogen receptor α methylation by the lysine methyltransferase SMYD2

(2018) Wolfgang M. J. Obermann   JOURNAL OF BIOLOGICAL CHEMISTRY

NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits

(2018) Yuehong Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells

(2018) Sebastien Z. Causse et al.   ONCOGENE

Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance

(2018) Sara Zemanovic et al.   Cell Reports

The Emerging Role of Cohesin in the DNA Damage Response

(2018) Ireneusz Litwin et al.   Genes

The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

(2018) Tania Morán Luengo et al.   TRENDS IN CELL BIOLOGY

Base excision repair of oxidative DNA damage from mechanism to disease

(2017) Bret D Freudenthal   Frontiers in Bioscience-Landmark

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia

(2017) Taichiro Imahori et al.   NEUROSCIENCE

Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

(2017) Qingdi Quentin Li et al.   Scientific Reports

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

(2017) An Ning Cheng et al.   Scientific Reports

Regulators in the DNA damage response

(2016) Yunhua Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler

(2016) Frank J. Echtenkamp et al.   MOLECULAR CELL

The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining

(2016) Younghyun Lee et al.   RADIOTHERAPY AND ONCOLOGY

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation

(2016) Ameer L. Elaimy et al.   Oncotarget

ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis

(2016) Jessica L. Weatherbee et al.   Oncotarget

Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer

(2016) Akiharu Kimura et al.   Oncotarget

The role of Hsp70 in oxi-inflamm-aging and its use as a potential biomarker of lifespan

(2015) I. Martínez de Toda et al.   BIOGERONTOLOGY

HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas

(2015) Anne Ernst et al.   CANCER LETTERS

Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD

(2015) Xia Zhou et al.   HUMAN MOLECULAR GENETICS

Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines

(2015) Mayra L. Sottile et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

Endoplasmic Reticulum Stress, Genome Damage, and Cancer

(2015) Naomi Dicks et al.   Frontiers in Oncology

Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

(2014) Eun Jung Choi et al.   BMC CANCER

Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification

(2014) Won-Jun Jang et al.   CANCER SCIENCE

Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells

(2014) Gisela Natalia Castro et al.   CELL STRESS & CHAPERONES

Base excision repair: A critical player in many games

(2014) Susan S. Wallace   DNA REPAIR

Both the Charged Linker Region and ATPase Domain of Hsp90 Are Essential for Rad51-Dependent DNA Repair

(2014) Tanvi Suhane et al.   EUKARYOTIC CELL

The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets

(2014) Maria Katsogiannou et al.   MOLECULAR & CELLULAR PROTEOMICS

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis

(2014) Ioannis Kasioulis et al.   MOLECULAR BIOLOGY OF THE CELL

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

(2014) Qingming Fang et al.   Nature Communications

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma

(2013) Wei-ming Fu et al.   CELL BIOLOGY INTERNATIONAL

HspA1A facilitates DNA repair in human bronchial epithelial cells exposed to Benzo[a]pyrene and interacts with casein kinase 2

(2013) Yanying Duan et al.   CELL STRESS & CHAPERONES

Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis

(2013) Yimiao Xu et al.   CELLULAR SIGNALLING

ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51

(2013) Tohru Yamamori et al.   FEBS LETTERS

Patients With Colorectal Tumors With Microsatellite Instability and Large Deletions in HSP110 T17 Have Improved Response to 5-Fluorouracil–Based Chemotherapy

(2013) Ada Collura et al.   GASTROENTEROLOGY

Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair

(2013) David M. Guttmann et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates

(2013) Rayees U. H. Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents

(2013) Xiaokai Li et al.   ACS Medicinal Chemistry Letters

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of (2S)-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor

(2012) Se-Ho Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage

(2012) Shane Zaidi et al.   PLoS One

Heat shock protein 90  (HSP90 ), a substrate and chaperone of DNA-PK necessary for the apoptotic response

(2012) S. Solier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation

(2012) S. R. Stecklein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells

(2012) Jen-Chung Ko et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy

(2011) Anne-Laure Rérole et al.   CANCER RESEARCH

The FANC pathway and mitosis: A replication legacy

(2011) Valeria Naim et al.   CELL CYCLE

RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

(2011) Jörg-Christian Heinrich et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer

(2011) M. Scaltriti et al.   MOLECULAR CANCER THERAPEUTICS

Hsp90 Inhibitor-Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage

(2011) K. Ha et al.   MOLECULAR CANCER THERAPEUTICS

Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis

(2011) Coralie Dorard et al.   NATURE MEDICINE

Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers

(2011) B Gibert et al.   ONCOGENE

Loss of HSF1 Results in Defective Radiation-Induced G2Arrest and DNA Repair

(2011) Qiang Li et al.   RADIATION RESEARCH

Geldanamycin-Induced PCNA Degradation in Isolated Hsp90 Complex from Cancer Cells

(2010) Xing Wang et al.   CANCER INVESTIGATION

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Hsp90 modulates CAG repeat instability in human cells

(2010) David Mittelman et al.   CELL STRESS & CHAPERONES

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

(2010) Andrew J. Woodhead et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase η at Replication Stalling Sites in UV-Irradiated Cells

(2010) Takayuki Sekimoto et al.   MOLECULAR CELL

The program for processing newly synthesized histones H3.1 and H4

(2010) Eric I Campos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

(2010) S. Stangl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

(2009) Kenneth H. Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

(2009) F. A. Dungey et al.   MOLECULAR CANCER THERAPEUTICS

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene

(2009) Jin Yang et al.   TOXICOLOGY

A comparison of Hsp90α and Hsp90β interactions with cochaperones and substrates

(2008) Aliakbar Taherian et al.   Biochemistry and Cell Biology

Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks

(2008) Polychronis Kotoglou et al.   CELL STRESS & CHAPERONES

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair

(2008) T. T. Koll et al.   MOLECULAR CANCER THERAPEUTICS

The Kleisin Subunit of Cohesin Dictates Damage-Induced Cohesion

(2008) Jill M. Heidinger-Pauli et al.   MOLECULAR CELL