The HLJ1 -targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

(2011) Jen-Yi Lee et al.   PLoS One

DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1

(2010) Jing Zhang et al.   CANCER BIOLOGY & THERAPY

Tumor Suppressor HLJ1 Binds and Functionally Alters Nucleophosmin via Activating Enhancer Binding Protein 2  Complex Formation

(2010) T.-P. Chang et al.   CANCER RESEARCH

Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway

(2010) Yi-Chieh Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

(2010) W. Hsiao et al.   PLANTA MEDICA

High-Content, Image-Based Screening for Drug Targets in Yeast

(2010) Shinsuke Ohnuki et al.   PLoS One

Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression

(2009) Ming-Der Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Progress of research in antitumor mechanisms with Chinese medicine

(2009) Shu-yan Han et al.   Chinese Journal of Integrative Medicine

Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmCold™)

(2009) C.V. Chandrasekaran et al.   FOOD AND CHEMICAL TOXICOLOGY

Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells

(2008) Lu Yang et al.   CANCER LETTERS

Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1

(2008) H.-W. Chen et al.   CANCER RESEARCH

Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide

(2008) Ming-Der Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells

(2008) Feng-Yao Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Matrices de ADN: visión general y aplicaciones específicas

(2008) Amets Sáenz et al.   MEDICINA CLINICA

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

(2008) Jakob Nilsson et al.   NATURE CELL BIOLOGY