Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiation, Induces Apoptosis and Inhibits MAPK, JAK/STAT3, β-Catenin/NOTCH, and SOCS3 Signaling

The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells

(2022) Hamid Cheshomi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling

(2022) Niraj Kumar Jha et al.   SEMINARS IN CANCER BIOLOGY

The Nrf2 Pathway in Liver Diseases

(2022) Jiaming Zhou et al.   Frontiers in Cell and Developmental Biology

Recent advances in systemic therapy for hepatocellular carcinoma

(2022) Huajun Zhang et al.   Biomarker Research

The Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Effects of a Pomegranate-Peel Extract against Acrylamide-Induced Hepatotoxicity in Rats

(2022) Samy Sayed et al.   Life-Basel

Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment

(2022) Peiyu Xue et al.   PHYTOMEDICINE

Pomegranate and Its Components, Punicalagin and Ellagic Acid, Promote Antidepressant, Antioxidant, and Free Radical-Scavenging Activity in Ovariectomized Rats

(2022) Nancy Cervantes-Anaya et al.   Frontiers in Behavioral Neuroscience

SOCS3 Acts as an Onco-immunological Biomarker With Value in Assessing the Tumor Microenvironment, Pathological Staging, Histological Subtypes, Therapeutic Effect, and Prognoses of Several Types of Cancer

(2022) Lirui Dai et al.   Frontiers in Oncology

Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook

(2022) Yinjie Fan et al.   Journal of Hepatocellular Carcinoma

Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB/AP-1 pathway and TLR4 expression

(2022) Xiaolian Li et al.   Cell Death Discovery

Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling

(2022) Emma M.R. Koelman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New thiophene derivative augments the antitumor activity of γ-irradiation against colorectal cancer in mice via anti-inflammatory and pro-apoptotic pathways

(2022) Nermeen M. ElBakary et al.   Discover Oncology

Hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Disease Primers

PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action

(2021) Miguel Hernandez-Quiles et al.   Frontiers in Endocrinology

PPAR-α Modulators as Current and Potential Cancer Treatments

(2021) Yan Tan et al.   Frontiers in Oncology

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma

(2021) Hyuk Moon et al.   Cancers

Pomegranate extract ameliorates renal ischemia/reperfusion injury in rats via suppressing NF-κB pathway

(2021) Mirhan N Makled et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

(2021) Heba A. Fahmy et al.   JOURNAL OF FOOD BIOCHEMISTRY

A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

(2021) Haoyang Zou et al.   PHYTOMEDICINE

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core–Shell-Radiosensitizer for Breast Cancer Therapy

(2021) Mostafa A. Askar et al.   Cancers

The Role of Cancer Stem Cells in Radiation Resistance

(2020) Christoph Reinhold Arnold et al.   Frontiers in Oncology

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

(2020) Mao-lin Wan et al.   BIOSCIENCE REPORTS

Identification of deleterious NOTCH mutation as novel predictor to efficacious immunotherapy in NSCLC

(2020) Kai Zhang et al.   CLINICAL CANCER RESEARCH

Ellagic acid and human cancers: a systems pharmacology and docking study to identify principal hub genes and main mechanisms of action

(2020) Hamid Cheshomi et al.   MOLECULAR DIVERSITY

Systemic therapy of advanced hepatocellular carcinoma

(2020) Peter R Galle et al.   Future Oncology

Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells

(2020) Li Ren et al.   FOOD CHEMISTRY

Silencing microRNA‐221/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine signaling‐3‐dependent JAK/STAT pathway

(2019) Chun‐Hua Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress

(2019) Sung-Yong Yang et al.   BMC Complementary and Alternative Medicine

Insights into the success and failure of systemic therapy for hepatocellular carcinoma

(2019) Jordi Bruix et al.   Nature Reviews Gastroenterology & Hepatology

PPAR γ agonist, pioglitazone, suppresses melanoma cancer in mice by inhibiting TLR4 signaling

(2019) Nasim Dana et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Pomegranate peel extract ameliorates liver fibrosis induced by carbon tetrachloride in rats through suppressing p38MAPK/Nrf2 pathway

(2019) Xianglan Wei et al.   Journal of Functional Foods

Possible use of Punica granatum (Pomegranate) in cancer therapy

(2018) Amrita Devi Khwairakpam et al.   PHARMACOLOGICAL RESEARCH

Antimicrobial activity of pomegranate peel extracts performed by high pressure and enzymatic assisted extraction

(2018) Elisabete M.C. Alexandre et al.   FOOD RESEARCH INTERNATIONAL

Saponins as modulators of nuclear receptors

(2018) Tiehua Zhang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

(2018) Claudia Ceci et al.   Nutrients

Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice

(2017) Amina M Medhat et al.   TUMOR BIOLOGY

Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways

(2017) Animesh Mandal et al.   Nutrients

Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study

(2017) Ujjal Das et al.   Scientific Reports

Effect of Pomegranate Hull Extract on Liver Neoplastic Changes in Rats: More than an Antioxidant

(2016) Nahla E. El-Ashmawy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway

(2013) Deepak Bhatia et al.   Evidence-based Complementary and Alternative Medicine

Activation of the NF-κB Pathway by the STAT3 Inhibitor JSI-124 in Human Glioblastoma Cells

(2013) Braden C. McFarland et al.   MOLECULAR CANCER RESEARCH

Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats

(2012) Maria Angeles Rosillo et al.   PHARMACOLOGICAL RESEARCH

Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms

(2011) Anupam Bishayee et al.   CARCINOGENESIS

Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

(2011) Ya-Chen Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Inhibitory Effects of the Polyphenol Ellagic Acid on Inflammatory Mediators NF-κB, iNOS, COX-2, TNF-α, and IL-6 in 1,2-Dimethylhydrazine-Induced Rat Colon Carcinogenesis

(2010) Syed Umesalma et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Cancer gene discovery in hepatocellular carcinoma

(2010) Lars Zender et al.   JOURNAL OF HEPATOLOGY

Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice

(2009) Pei-chun Chao et al.   Nutrition & Metabolism