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Title
PPAR-α Modulators as Current and Potential Cancer Treatments
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-03-23
DOI
10.3389/fonc.2021.599995
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- (2019) Yanhua Mou et al. Journal of Hematology & Oncology
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- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
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- (2018) Weiwei Yang et al. MOLECULAR CELL
- Analysis of DNA methylation in cancer: location revisited
- (2018) Alexander Koch et al. Nature Reviews Clinical Oncology
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- (2018) Marcus D. Goncalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2015) L. A. Torre et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Unknown
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- (2015) Xiao-Qing Li et al. TUMORI
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- (2015) Wojciech G. Garbacz et al. PPAR Research
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- (2015) Dongfeng Han et al. Oncotarget
- Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer
- (2015) Karthic Chandran et al. Oncotarget
- Enhancement of Radiosensitivity in Human Esophageal Carcinoma Cells by Fenofibrate and Its Potential Mechanism
- (2015) Xiao-Qing Li et al. TUMORI JOURNAL
- Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells
- (2015) Sho Tabata et al. Oncotarget
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- (2014) Melissa J. Wilking et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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- (2014) David Taïeb et al. ENDOCRINE REVIEWS
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- Expression of P450 and nuclear receptors in normal and end-stage Chinese livers
- (2014) Hong Chen WORLD JOURNAL OF GASTROENTEROLOGY
- Bezafibrate and medroxyprogesterone acetate in resistant and relapsed endemic Burkitt lymphoma in Malawi; an open-label, single-arm, phase 2 study (ISRCTN34303497)
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- (2013) Huiyun Liang et al. MOLECULAR CARCINOGENESIS
- PPAR-α as a Key Nutritional and Environmental Sensor for Metabolic Adaptation
- (2013) Alejandra V. Contreras et al. Advances in Nutrition
- Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma
- (2012) Ji Sun Woo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886
- (2012) S. M. Kim et al. CANCER RESEARCH
- Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro
- (2012) Anna Wilk et al. CELL CYCLE
- Examining the safety of PPAR agonists – current trends and future prospects
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- (2012) D E Spaner et al. LEUKEMIA
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- (2012) Walter Wahli et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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- (2012) Joo-In Park et al. PPAR Research
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- (2010) Ambra Pozzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Apostolia-Maria Tsimberidou et al. CANCER
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- (2009) Jung Yeon Lim et al. JOURNAL OF NEURO-ONCOLOGY
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- (2009) N. Bougarne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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