Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: A molecular and histopathological study

(2016) ZEIN SHABAN IBRAHIM et al.   Molecular Medicine Reports

Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms

(2016) Dona Sinha et al.   SEMINARS IN CANCER BIOLOGY

Anti Tumoral Properties of Punica Granatum (Pomegranate) Peel Extract on Different Human Cancer Cells

(2015) Sina Modaeinama et al.   Asian Pacific Journal of Cancer Prevention

Efficacy and Safety of Pomegranate Medicinal Products for Cancer

(2015) Christian Vlachojannis et al.   Evidence-based Complementary and Alternative Medicine

Punica granatum cv. Dente di Cavallo seed ethanolic extract: Antioxidant and antiproliferative activities

(2015) Paolo Lucci et al.   FOOD CHEMISTRY

Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/β-Catenin Signaling Pathways

(2015) Animesh Mandal et al.   MOLECULES

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis

(2015) Anupam Bishayee et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy

(2015) Eleonora Turrini et al.   Oxidative Medicine and Cellular Longevity

Impact of Obesity on Mammary Gland Inflammation and Local Estrogen Production

(2014) Kristy A. Brown   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Pomegranate Fruit as a Rich Source of Biologically Active Compounds

(2014) Sreeja Sreekumar et al.   Biomed Research International

Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence

(2014) Sarah Crawford   Therapeutic Advances in Medical Oncology

Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities

(2013) Deeba Syed et al.   Anti-Cancer Agents in Medicinal Chemistry

Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer

(2013) Bhupendra Singh et al.   BMC CANCER

Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice

(2013) K. Subbaramaiah et al.   Cancer Prevention Research

Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer

(2013) L. R. Howe et al.   CLINICAL CANCER RESEARCH

Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents

(2013) Monica Viladomiu et al.   Evidence-based Complementary and Alternative Medicine

Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness

(2013) Claudia Bocca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Chemical Composition and Antioxidant, Anti-Inflammatory, and Antiproliferation Activities of Pomegranate (Punica granatum) Flowers

(2013) Jalila Bekir et al.   JOURNAL OF MEDICINAL FOOD

Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks

(2013) Amit B. Shirode et al.   MOLECULAR CARCINOGENESIS

Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis

(2013) Animesh Mandal et al.   MOLECULAR CARCINOGENESIS

Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation

(2012) Nivedita Banerjee et al.   BREAST CANCER RESEARCH AND TREATMENT

Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer

(2012) Ana Rocha et al.   BREAST CANCER RESEARCH AND TREATMENT

Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer

(2012) Bhupendra Singh et al.   CARCINOGENESIS

Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

(2012) Adeel Zubair et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Chemopreventive and Chemotherapeutic Potential of Curcumin in Breast Cancer

(2012) Dona Sinha et al.   CURRENT DRUG TARGETS

New Paradigm for Intrinsic Function of Heat Shock Proteins as Endogenous Ligands in Inflammation and Innate Immunity

(2012) Y. Tamura et al.   CURRENT MOLECULAR MEDICINE

HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways

(2012) Samuel K. Shimp et al.   INFLAMMATION RESEARCH

Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects

(2012) Tariq Ismail et al.   JOURNAL OF ETHNOPHARMACOLOGY

Minireview: Inflammation: An Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast Cancers

(2012) Sarah C. Baumgarten et al.   MOLECULAR ENDOCRINOLOGY

Act1-hsp90 heats up TH17 inflammation

(2012) Pawan Kumar et al.   NATURE IMMUNOLOGY

Pomegranate as a Functional Food and Nutraceutical Source

(2012) Suzanne D. Johanningsmeier et al.   Annual Review of Food Science and Technology

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Nrf2: control of sensitivity to carcinogens

(2011) Stephen L. Slocum et al.   ARCHIVES OF TOXICOLOGY

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

(2011) M.A. Rosillo et al.   BIOCHEMICAL PHARMACOLOGY

A systematic review to establish the frequency of cyclooxygenase-2 expression in normal breast epithelium, ductal carcinoma in situ, microinvasive carcinoma of the breast and invasive breast cancer

(2011) J A Glover et al.   BRITISH JOURNAL OF CANCER

Targeting the inflammatory pathways to enhance chemotherapy of cancer

(2011) Zhaowei Zhu et al.   CANCER BIOLOGY & THERAPY

Carnosol: A promising anti-cancer and anti-inflammatory agent

(2011) Jeremy J. Johnson   CANCER LETTERS

Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer

(2011) B. Singh et al.   CARCINOGENESIS

Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms

(2011) Anupam Bishayee et al.   CARCINOGENESIS

The Bioactivity of Pomegranate: Impact on Health and Disease

(2011) Ana Faria et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Heat Shock Proteins: A Potential Anticancer Target

(2011) Kamalesh K. Sankhala et al.   CURRENT DRUG TARGETS

Molecular chaperones in mammary cancer growth and breast tumor therapy

(2011) Stuart K. Calderwood et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Antioxidant Potency of Punica granatum L. Fruit Peel Reduces Cell Proliferation and Induces Apoptosis on Breast Cancer

(2011) Miris Dikmen et al.   JOURNAL OF MEDICINAL FOOD

Pomegranate extract demonstrate a selective estrogen receptor modulator profile in human tumor cell lines and in vivo models of estrogen deprivation

(2011) Sreekumar Sreeja et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications

(2011) Antonio Macciò et al.   TheScientificWorldJOURNAL

Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory

(2010) Rong Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pomegranate Ellagitannin-Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro

(2010) L. S. Adams et al.   Cancer Prevention Research

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis

(2010) Joydeb Kumar Kundu et al.   PHARMACEUTICAL RESEARCH

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

(2010) Ilaria Bellezza et al.   Cancers

Pomegranate Fruit Extract Impairs Invasion and Motility in Human Breast Cancer

(2009) Gazala N. Khan et al.   INTEGRATIVE CANCER THERAPIES

Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats

(2009) Tarek Boussetta et al.   PLoS One

Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

(2009) R. E. Harris   INFLAMMOPHARMACOLOGY

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

(2008) S Nair et al.   BRITISH JOURNAL OF CANCER

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Nuclear Factor-κB Activation: From Bench to Bedside

(2008) Gautam Sethi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro

(2008) Meenakshi Shukla et al.   Journal of Inflammation-London

Pomegranate juice: a heart-healthy fruit juice

(2008) Arpita Basu et al.   NUTRITION REVIEWS