Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) during pregnancy in the Sprague-Dawley rat

Per- and polyfluoroalkyl substances in the environment

(2022) Marina G. Evich et al.   SCIENCE

Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action

(2022) Leo T.M. Van Der Ven et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects?

(2022) Andreas Kortenkamp   ENVIRONMENTAL HEALTH PERSPECTIVES

Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs)

(2022) Carrie A. McDonough et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring

(2022) Wieneke Bil et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays

(2022) Nicola Evans et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

(2021) Styliani Fragki et al.   CRITICAL REVIEWS IN TOXICOLOGY

FluoroMatch 2.0—making automated and comprehensive non-targeted PFAS annotation a reality

(2021) Jeremy P. Koelmel et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

(2021) Rahel L. Birru et al.   Environmental Health

Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort

(2021) Annelise J. Blomberg et al.   ENVIRONMENTAL RESEARCH

Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome—An Examination Using Triclosan and Perfluorohexane Sulfonate

(2021) Mary E Gilbert et al.   TOXICOLOGICAL SCIENCES

Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure

(2021) Keith A. Houck et al.   TOXICOLOGY

Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet

(2021) J.J. Schlezinger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury

(2021) Katherine Roth et al.   ENVIRONMENT INTERNATIONAL

Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach

(2021) Che-Jung Chang et al.   ENVIRONMENT INTERNATIONAL

A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat

(2021) Justin M. Conley et al.   ENVIRONMENT INTERNATIONAL

Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS)

(2021) Justin M. Conley et al.   ENVIRONMENT INTERNATIONAL

The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics

(2021) Gargi Dixit et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure

(2021) Emily S. Marques et al.   TOXICOLOGY

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

(2020) Bevin E. Blake et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The association between isolated maternal hypothyroxinemia in early pregnancy and preterm birth

(2020) Xi Yang et al.   THYROID

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

(2020) Nadine Kotlarz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Risk Assessment of Per‐ and Polyfluoroalkyl Substances (PFASs) Mixtures: A Relative Potency Factor Approach

(2020) Wieneke Bil et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Nontargeted mass-spectral detection of chloroperfluoropolyether carboxylates in New Jersey soils

(2020) John W. Washington et al.   SCIENCE

Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects

(2020) Bevin E. Blake et al.   TOXICOLOGY

Risk to human health related to the presence of perfluoroalkyl substances in food

(2020) et al.   EFSA Journal

Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat

(2020) Justin M. Conley et al.   ENVIRONMENT INTERNATIONAL

Ten years of research on synergisms and antagonisms in chemical mixtures: A systematic review and quantitative reappraisal of mixture studies

(2020) Olwenn Martin et al.   ENVIRONMENT INTERNATIONAL

Assessing the human health risks of per- and polyfluoroalkyl substances: A need for greater focus on their interactions as mixtures

(2020) Atinuke F. Ojo et al.   JOURNAL OF HAZARDOUS MATERIALS

Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats

(2019) Justin M. Conley et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration

(2019) Anika L. Dzierlenga et al.   XENOBIOTICA

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

(2019) Anne-Cathrin Behr et al.   TOXICOLOGY IN VITRO

Validation of quantitative measurements and semi-quantitative estimates of emerging perfluoroethercarboxylic acids (PFECAs) and hexfluoroprolyene oxide acids (HFPOAs)

(2018) James McCord et al.   JOURNAL OF CHROMATOGRAPHY A

Determination of free thyroid hormones in animal serum/plasma using ultrafiltration in combination with ultra-fast liquid chromatography-tandem mass spectrometry

(2018) Rumi Tanoue et al.   JOURNAL OF CHROMATOGRAPHY A

Regulate to reduce chemical mixture risk

(2018) Andreas Kortenkamp et al.   SCIENCE

Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study

(2018) Katherine L O’Shaughnessy et al.   TOXICOLOGICAL SCIENCES

Mixed “Antiandrogenic” Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat

(2018) Justin M Conley et al.   TOXICOLOGICAL SCIENCES

The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development

(2018) Fan Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects

(2018) Elsie M. Sunderland et al.   Journal of Exposure Science and Environmental Epidemiology

PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling

(2017) Mitchell B. Rosen et al.   TOXICOLOGY

Developmental toxicity of perfluorononanoic acid in mice

(2015) Kaberi P. Das et al.   REPRODUCTIVE TOXICOLOGY

In Vitro,Ex Vivo, andIn VivoDetermination of Thyroid Hormone Modulating Activity of Benzothiazoles

(2015) Michael W. Hornung et al.   TOXICOLOGICAL SCIENCES

Quantifying Synergy: A Systematic Review of Mixture Toxicity Studies within Environmental Toxicology

(2014) Nina Cedergreen   PLoS One

Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation

(2014) Cynthia J. Wolf et al.   TOXICOLOGY

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

(2011) Alan Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model

(2011) Anne E. Loccisano et al.   REPRODUCTIVE TOXICOLOGY

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

(2011) J.A. Bjork et al.   TOXICOLOGY

AIC model selection and multimodel inference in behavioral ecology: some background, observations, and comparisons

(2010) Kenneth P. Burnham et al.   BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY

Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity

(2010) C. V. Rider et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats

(2009) John L. Butenhoff et al.   REPRODUCTIVE TOXICOLOGY

Cumulative and Antagonistic Effects of a Mixture of the Antiandrogens Vinclozolin and Iprodione in the Pubertal Male Rat

(2009) Chad R. Blystone et al.   TOXICOLOGICAL SCIENCES

Roles of Rat Renal Organic Anion Transporters in Transporting Perfluorinated Carboxylates with Different Chain Lengths

(2009) Yi M. Weaver et al.   TOXICOLOGICAL SCIENCES

A two-generation oral gavage reproduction study with potassium perfluorobutanesulfonate (K+PFBS) in Sprague Dawley rats

(2009) Paul H. Lieder et al.   TOXICOLOGY

A mixture of seven antiandrogens induces reproductive malformations in rats

(2008) Cynthia V. Rider et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPARα) in the mouse

(2008) Barbara D. Abbott et al.   REPRODUCTIVE TOXICOLOGY

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

(2008) Kembra L. Howdeshell et al.   TOXICOLOGICAL SCIENCES

Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression

(2008) James A. Bjork et al.   TOXICOLOGY