Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

(2020) Shaza Gaballah et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Solvent Suitability for HFPO-DA (“GenX” Parent Acid) in Toxicological Studies

(2020) Hannah K. Liberatore et al.   Environmental Science & Technology Letters

A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

(2019) Grace Patlewicz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications

(2019) Agha Zeeshan Mirza et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats

(2019) Justin M. Conley et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Analysis of F-53B, Gen-X, ADONA, and emerging fluoroalkylether substances in environmental and biomonitoring samples: A review

(2019) Gabriel Munoz et al.   Trends in Environmental Analytical Chemistry

Multiple pathways of human exposure to poly- and perfluoroalkyl substances (PFASs): From external exposure to human blood

(2019) Somrutai Poothong et al.   ENVIRONMENT INTERNATIONAL

A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid

(2019) Paolo Girardi et al.   ENVIRONMENTAL RESEARCH

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

(2019) Anne-Cathrin Behr et al.   TOXICOLOGY IN VITRO

Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro

(2018) Anne-Cathrin Behr et al.   TOXICOLOGY LETTERS

Evaluating biological activity of compounds by transcription factor activity profiling

(2018) Alexander Medvedev et al.   Science Advances

A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?

(2017) Zhanyun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comparison of phenotypic and global gene expression changes in Xenopus tropicalis embryos induced by agonists of RAR and RXR

(2017) Jingmin Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

(2017) Antony J. Williams et al.   Journal of Cheminformatics

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid

(2016) Taiki Abe et al.   ARCHIVES OF TOXICOLOGY

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

(2016) Ann M. Richard et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community

(2016) Lyndsey A. Darrow et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Current Status and Future Challenges in Molecular Design for Reduced Hazard

(2016) Philip Coish et al.   ACS Sustainable Chemistry & Engineering

Fluorinated alkyl substances and technical mixtures used in food paper-packaging exhibit endocrine-related activity in vitro

(2016) A. K. Rosenmai et al.   Andrology

Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

(2015) Shengmin Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanistic approach for the toxic effects of perfluorooctanoic acid on isolated rat liver and brain mitochondria

(2015) V Mashayekhi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos

(2015) Hui Liu et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Developmental toxicity of perfluorononanoic acid in mice

(2015) Kaberi P. Das et al.   REPRODUCTIVE TOXICOLOGY

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors

(2015) Marina Grimaldi et al.   Frontiers in Neuroscience

Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population

(2014) Kim E Innes et al.   BMC CANCER

Global emission inventories for C4–C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, part II: The remaining pieces of the puzzle

(2014) Zhanyun Wang et al.   ENVIRONMENT INTERNATIONAL

Global emission inventories for C4–C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, Part I: production and emissions from quantifiable sources

(2014) Zhanyun Wang et al.   ENVIRONMENT INTERNATIONAL

Minireview: Challenges and Opportunities in Development of PPAR Agonists

(2014) Matthew B. Wright et al.   MOLECULAR ENDOCRINOLOGY

Structure-Based Investigation on the Interaction of Perfluorinated Compounds with Human Liver Fatty Acid Binding Protein

(2013) Lianying Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases

(2012) Je-Min Choi et al.   MOLECULES AND CELLS

Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

(2012) E. Wincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides

(2011) Kentaro Rikimaru et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Levels of Perfluorinated Compounds in Food and Dietary Intake of PFOS and PFOA in The Netherlands

(2011) Cornelle W. Noorlander et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Impact of perfluorooctanesulfonate and perfluorooctanoic acid on human peripheral leukocytes

(2011) Anne Brieger et al.   TOXICOLOGY IN VITRO

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR

(2010) Clifford R. Elcombe et al.   ARCHIVES OF TOXICOLOGY

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

(2010) Marta Moya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Estrogen-Like Activity of Perfluoroalkyl Acids In Vivo and Interaction with Human and Rainbow Trout Estrogen Receptors In Vitro

(2010) Abby D. Benninghoff et al.   TOXICOLOGICAL SCIENCES

Perfluoroalkyl Contaminants in an Arctic Marine Food Web: Trophic Magnification and Wildlife Exposure

(2009) Barry C. Kelly et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors

(2008) Sergei Romanov et al.   NATURE METHODS

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perfluorocarboxylic Acids Induce Cytochrome P450 Enzymes in Mouse Liver through Activation of PPAR-α and CAR Transcription Factors

(2008) Xingguo Cheng et al.   TOXICOLOGICAL SCIENCES

Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR

(2008) Mitchell B. Rosen et al.   TOXICOLOGICAL SCIENCES