Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet

Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease

(2021) Ebru S. Selen et al.   JCI Insight

Associations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study

(2020) Gang Liu et al.   Environmental Health

Increased Cardiovascular Risk Associated with Chemical Sensitivity to Perfluoro–Octanoic Acid: Role of Impaired Platelet Aggregation

(2020) Luca De Toni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water

(2020) Ying Li et al.   Environmental Health

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

(2020) Marion Régnier et al.   Scientific Reports

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

(2020) Zhiqiang Pang et al.   Metabolites

Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)

(2020) Karina Dale et al.   AQUATIC TOXICOLOGY

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

(2020) Aidan McGlinchey et al.   ENVIRONMENT INTERNATIONAL

Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a Science Park in Taiwan

(2020) Te-Wei Lin et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity

(2020) Marisa Pfohl et al.   TOXICOLOGICAL SCIENCES

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

(2020) J.J. Schlezinger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region

(2020) Cristina Canova et al.   ENVIRONMENT INTERNATIONAL

PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes

(2020) Hannah Gardener et al.   ENVIRONMENTAL RESEARCH

PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding

(2020) Amila O. De Silva et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Comparative Transcriptomics Analyses in Livers of Mice, Humans, and Humanized Mice Define Human-Specific Gene Networks

(2020) Chengfei Jiang et al.   Cells

Hepatic Monoacylglycerol Acyltransferase 1 is Induced by Prolonged Food Deprivation to Modulate the Hepatic Fasting Response

(2019) Andrew J. Lutkewitte et al.   JOURNAL OF LIPID RESEARCH

Dose effects of ammonium perfluorooctanoate on lipoprotein metabolism in APOE*3-Leiden.CETP mice

(2019) Marianne G Pouwer et al.   TOXICOLOGICAL SCIENCES

Using 2003–2014 U.S. NHANES data to determine the associations between per- and polyfluoroalkyl substances and cholesterol: Trend and implications

(2019) Zhaomin Dong et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Are Liquid Sugars Different from Solid Sugar in Their Ability to Cause Metabolic Syndrome?

(2019) Gerhard Sundborn et al.   Obesity

Omics approach reveals perturbation of metabolism and phenotype in Caenorhabditis elegans triggered by perfluorinated compounds

(2019) Hyung Min Kim et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The association between total serum isomers of per- and polyfluoroalkyl substances, lipid profiles, and the DNA oxidative/nitrative stress biomarkers in middle-aged Taiwanese adults

(2019) Chien-Yu Lin et al.   ENVIRONMENTAL RESEARCH

Influence of exposure to perfluoroalkyl substances (PFASs) on the Korean general population: 10-year trend and health effects

(2018) Sung-Hee Seo et al.   ENVIRONMENT INTERNATIONAL

Serum polyfluoroalkyl chemicals are associated with risk of cardiovascular diseases in national US population

(2018) Mengmeng Huang et al.   ENVIRONMENT INTERNATIONAL

Evaluation and Management Strategies for Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water Aquifers: Perspectives from Impacted U.S. Northeast Communities

(2018) Jennifer L. Guelfo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PFOA is associated with diabetes and metabolic alteration in US men: National Health and Nutrition Examination Survey 2003–2012

(2018) Xiaowei He et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES

(2018) Judith M. Graber et al.   Journal of Exposure Science and Environmental Epidemiology

Roles of gender and obesity in defining correlations between perfluoroalkyl substances and lipid/lipoproteins

(2018) Ram B. Jain et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts

(2017) Nuria Matilla-Santander et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Relationship between peroxisome proliferator-activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells

(2017) Anna Kjerstine Rosenmai et al.   JOURNAL OF APPLIED TOXICOLOGY

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

(2017) Kaberi P. Das et al.   TOXICOLOGY

PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling

(2017) Mitchell B. Rosen et al.   TOXICOLOGY

Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk

(2017) Gema Frühbeck et al.   Adipocyte

SRF and MKL1 Independently Inhibit Brown Adipogenesis

(2017) Matthias Rosenwald et al.   PLoS One

The precautionary principle and chemicals management: The example of perfluoroalkyl acids in groundwater

(2016) Ian T. Cousins et al.   ENVIRONMENT INTERNATIONAL

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants

(2016) Xindi C. Hu et al.   Environmental Science & Technology Letters

Association of polyfluoroalkyl chemical exposure with serum lipids in children

(2015) Xiao-Wen Zeng et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Perfluorooctanoic acid (PFOA) affects distinct molecular signalling pathways in human primary hepatocytes

(2015) Thorsten Buhrke et al.   TOXICOLOGY

Fatty acid metabolism and the basis of brown adipose tissue function

(2015) María Calderon-Dominguez et al.   Adipocyte

Helsingør Statement on poly- and perfluorinated alkyl substances (PFASs)

(2014) Martin Scheringer et al.   CHEMOSPHERE

A single amino acid change humanizes long-chain fatty acid binding and activation of mouse peroxisome proliferator-activated receptor α

(2014) Dhawal P. Oswal et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Integrated Proteomic and miRNA Transcriptional Analysis Reveals the Hepatotoxicity Mechanism of PFNA Exposure in Mice

(2014) Jianshe Wang et al.   JOURNAL OF PROTEOME RESEARCH

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

(2014) Xiaobing Tan et al.   PLoS One

Association between levels of serum perfluorooctane sulfate and carotid artery intima–media thickness in adolescents and young adults

(2013) Chien-Yu Lin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid

(2013) Siyuan Peng et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths

(2013) Thorsten Buhrke et al.   TOXICOLOGY LETTERS

Circulating microRNA profiles altered in mice after 28d exposure to perfluorooctanoic acid

(2013) Shengmin Yan et al.   TOXICOLOGY LETTERS

Treatment of poly- and perfluoroalkyl substances in U.S. full-scale water treatment systems

(2013) Timothy D. Appleman et al.   WATER RESEARCH

Perfluorooctanoic Acid and Cardiovascular Disease in US Adults

(2012) Anoop Shankar et al.   ARCHIVES OF INTERNAL MEDICINE

Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections

(2012) Miguel Galarraga et al.   JOURNAL OF LIPID RESEARCH

Cell Autonomous Lipin 1 Function Is Essential for Development and Maintenance of White and Brown Adipose Tissue

(2012) K. Nadra et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice

(2011) Tomohiko Nakagawa et al.   ARCHIVES OF TOXICOLOGY

Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 compounds

(2011) Cynthia J. Wolf et al.   REPRODUCTIVE TOXICOLOGY

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

(2011) J.A. Bjork et al.   TOXICOLOGY

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR

(2010) Clifford R. Elcombe et al.   ARCHIVES OF TOXICOLOGY

Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)

(2010) Kyle Steenland et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Role of Peroxisome Proliferator-activated Receptor-α in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver

(2010) Mutsuko MINATA et al.   INDUSTRIAL HEALTH

Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice

(2010) Mousumi Rahman Qazi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant

(2009) K. Steenland et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

(2009) Tadeja Režen et al.   BMC GENOMICS

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα

(2009) Toshiki Nakamura et al.   TOXICOLOGY

Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion

(2008) Zhouji Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH

Evaluation of the Immune System in Rats and Mice Administered Linear Ammonium Perfluorooctanoate

(2008) Scott E. Loveless et al.   TOXICOLOGICAL SCIENCES

Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice

(2008) Inchio Lou et al.   TOXICOLOGICAL SCIENCES

Activation of Mouse and Human Peroxisome Proliferator−Activated Receptor Alpha by Perfluoroalkyl Acids of Different Functional Groups and Chain Lengths

(2008) Cynthia J. Wolf et al.   TOXICOLOGICAL SCIENCES

Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid

(2007) Hongxia Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY