Store-operated calcium entry: From physiology to tubular aggregate myopathy

Enforced tethering elongates the cortical endoplasmic reticulum and limits store-operated calcium entry

(2022) Christopher Henry et al.   JOURNAL OF CELL SCIENCE

Pharmacological blockade of angiotensin II receptor restores diabetes-associated reduction of store operated Ca2+ entry in adult cardiomyocytes

(2022) Yasin Gökçe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of STIM and Orai function by post-translational modifications

(2022) Jinsy Johnson et al.   CELL CALCIUM

CRAC channel inhibitors in pancreatic pathologies

(2022) Oleg V. Gerasimenko et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39

(2022) Beatrice Riva et al.   CELL CALCIUM

Ryanodine receptor 1 ( RYR1 ) mutations in two patients with tubular aggregate myopathy

(2022) Gaetano Nicola Alfio Vattemi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy

(2022) Celia Cordero-Sanchez et al.   Blood Advances

Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice

(2022) Antonio Michelucci et al.   JOURNAL OF GENERAL PHYSIOLOGY

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome

(2021) Charles Bruen et al.   PANCREAS

The Mitochondrial Ca2+ Uniporter is a Central Regulator of Interorganellar Ca2+ Transfer and NFAT Activation

(2021) Ryan E. Yoast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer

(2021) Xiaojing Liang et al.   Frontiers in Pharmacology

Store-Operated Calcium Entry in Skeletal Muscle: What Makes It Different?

(2021) Elena Lilliu et al.   Cells

Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure

(2021) Roberto Silva-Rojas et al.   Cells

Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle

(2021) Hengtao Zhang et al.   JCI Insight

Pathological Mechanism of a Constitutively Active Form of Stromal Interaction Molecule 1 in Skeletal Muscle

(2021) Ji Hee Park et al.   Biomolecules

A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model

(2021) Joe A. Wrennall et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The interplay between mitochondria and store‐operated Ca 2+ entry: Emerging insights into cardiac diseases

(2021) Jinliang Nan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle

(2021) Seung Yeon Jeong et al.   Cells

Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass

(2021) Rebecca J. Wilson et al.   Molecular Metabolism

Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca 2+ Handling After Pressure Overload

(2020) Fiona Bartoli et al.   CIRCULATION

Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes

(2020) Matthias Sallinger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice

(2020) Antonio Michelucci et al.   JOURNAL OF GENERAL PHYSIOLOGY

Stimulation of ORAI1 expression, store-operated Ca2+ entry, and osteogenic signaling by high glucose exposure of human aortic smooth muscle cells

(2020) Ke Ma et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium entry units (CEUs): perspectives in skeletal muscle function and disease

(2020) Feliciano Protasi et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca2+ Selective Orai1 Pore

(2020) Linda Waldherr et al.   Cancers

Blockade of Store-Operated Calcium Entry Reduces IL-17/TNF Cytokine-Induced Inflammatory Response in Human Myoblasts

(2019) Audrey Beringer et al.   Frontiers in Immunology

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

Molecular basis of allosteric Orai1 channel activation by STIM1

(2019) Priscilla See‐Wai Yeung et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM calcium sensing and conformational change

(2019) Aparna Gudlur et al.   JOURNAL OF PHYSIOLOGY-LONDON

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

(2019) Yu-Ping Lin et al.   Nature Communications

Tubular aggregate myopathy and Stormorken syndrome: Mutation spectrum and genotype/phenotype correlation

(2019) Gilles Morin et al.   HUMAN MUTATION

A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy

(2019) Celia Cordero-Sanchez et al.   Disease Models & Mechanisms

Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle

(2019) Antonio Michelucci et al.   eLife

STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry

(2019) Agnieszka Dyrda et al.   CELL CALCIUM

CRAC Channels as Targets for Drug Discovery and Development

(2018) Kenneth A. Stauderman   CELL CALCIUM

Gain-of-function mutations in STIM1 and ORAI1 causing tubular aggregate myopathy and Stormorken syndrome

(2018) Johann Böhm et al.   CELL CALCIUM

Why don't mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis?

(2018) Pei Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics

(2018) Alice Rossi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and disease

(2018) Antonio Michelucci et al.   CELL CALCIUM

STIM1 over-activation generates a multi-systemic phenotype affecting skeletal muscle, spleen, eye, skin, bones, and the immune system in mice

(2018) Roberto Silva-Rojas et al.   HUMAN MOLECULAR GENETICS

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis

(2018) Beatrice Riva et al.   JOURNAL OF MEDICINAL CHEMISTRY

The whole cell Ca2+ release-activated Ca2+ current ICRAC is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na+

(2018) Krishna Samanta et al.   JOURNAL OF PHYSIOLOGY-LONDON

Addendum: Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle

(2018) Simona Boncompagni et al.   Scientific Reports

Identification and characterization of three novel mutations in the CASQ1 gene in four patients with tubular aggregate myopathy

(2017) Virginia Barone et al.   HUMAN MUTATION

ORAI1 Mutations with Distinct Channel Gating Defects in Tubular Aggregate Myopathy

(2017) Johann Böhm et al.   HUMAN MUTATION

Store-Operated Ca 2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

(2017) Martin Vaeth et al.   IMMUNITY

Complex phenotypes associated with STIM1 mutations in both coiled coil and EF-hand domains

(2017) Elizabeth Harris et al.   NEUROMUSCULAR DISORDERS

STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes

(2017) Mi Ri Oh et al.   Scientific Reports

Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle

(2017) Simona Boncompagni et al.   Scientific Reports

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia

(2017) Elena Conte et al.   Journal of Cachexia Sarcopenia and Muscle

Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH

(2017) D. Gavriliouk et al.   Scientific Reports

Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway

(2017) Saifur Rahman et al.   Scientific Reports

Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation

(2016) Lane Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A novel gain-of-function mutation inORAI1causes late-onset tubular aggregate myopathy and congenital miosis

(2016) M. Garibaldi et al.   CLINICAL GENETICS

Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry

(2016) Ellie M. Carrell et al.   FASEB JOURNAL

A quantitative description of tubular system Ca2+handling in fast- and slow-twitch muscle fibres

(2016) Tanya R. Cully et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inhibitory effects of SKF96365 on the activities of K+ channels in mouse small intestinal smooth muscle cells

(2016) Yasuyuki TANAHASHI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate

(2016) Ming Wei et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle

(2016) Angela M Thornton et al.   Aging-US

Variations in ORAI1 Gene Associated with Kawasaki Disease

(2016) Yoshihiro Onouchi et al.   PLoS One

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma

(2015) Cristina Esteve et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle

(2015) Alina Ainbinder et al.   CELL CALCIUM

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

(2015) Tyler P. Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca2+ sensor STIM1 and the Ca2+ channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization

(2014) David Holowka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays

(2014) Amir Masoud Sadaghiani et al.   CHEMISTRY & BIOLOGY

Enhanced Ca2+ influx from STIM1–Orai1 induces muscle pathology in mouse models of muscular dystrophy

(2014) Sanjeewa A. Goonasekera et al.   HUMAN MOLECULAR GENETICS

Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca2+ channels

(2014) Yukari Endo et al.   HUMAN MOLECULAR GENETICS

A Dominant STIM1 Mutation Causes Stormorken Syndrome

(2014) Doriana Misceo et al.   HUMAN MUTATION

STIM1 and SLC24A4 Are Critical for Enamel Maturation

(2014) S. Wang et al.   JOURNAL OF DENTAL RESEARCH

SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes

(2014) Kui-Hao Chen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive Activation of the Calcium Sensor STIM1 Causes Tubular-Aggregate Myopathy

(2013) Johann Böhm et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Involvement of TRPV2 and SOCE in calcium influx disorder in DMD primary human myotubes with a specific contribution of α1-syntrophin and PLC/PKC in SOCE regulation

(2013) Rania Harisseh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Molecular pharmacology of store-operated CRAC channels

(2013) Amit Jairaman et al.   Channels

Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions

(2013) Gang Chen et al.   MOLECULAR IMMUNOLOGY

Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue

(2013) Lan Wei-LaPierre et al.   Nature Communications

Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK

(2012) Florian Lang et al.   CELL CALCIUM

The action of selective CRAC channel blockers is affected by the Orai pore geometry

(2012) Isabella Derler et al.   CELL CALCIUM

Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress

(2012) Nadine Henke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Resting Intracellular Calcium Modulates NF-κB-dependent Inducible Nitric-oxide Synthase Gene Expression in DystrophicmdxSkeletal Myotubes

(2012) Francisco Altamirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarcoplasmic reticulum Ca2+permeation explored from the lumen side inmdxmuscle fibers under voltage control

(2012) Gaëlle Robin et al.   JOURNAL OF GENERAL PHYSIOLOGY

STIM1-Ca2+ Signaling Is Required for the Hypertrophic Growth of Skeletal Muscle in Mice

(2012) T. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Orai1 Mediates Exacerbated Ca2+ Entry in Dystrophic Skeletal Muscle

(2012) Xiaoli Zhao et al.   PLoS One

Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement

(2011) Simona Boncompagni et al.   AGE

Differential impact of mitochondrial positioning on mitochondrial Ca2+ uptake and Ca2+ spark suppression in skeletal muscle

(2011) Ann E. Rossi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

(2011) Basile Darbellay et al.   JOURNAL OF CELL BIOLOGY

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

(2011) S. Fuchs et al.   JOURNAL OF IMMUNOLOGY

STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function

(2011) Santeri Kiviluoto et al.   Skeletal Muscle

T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases

(2011) Lama Al-Qusairi et al.   Skeletal Muscle

Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle

(2010) Joshua N. Edwards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels

(2010) A Singh et al.   BRITISH JOURNAL OF PHARMACOLOGY

A new syndrome: thrombocytopathia, muscle fatigue, asplenia, miosis, migraine, dyslexia and ichthyosis

(2010) Helge Stormorken et al.   CLINICAL GENETICS

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

The Multifunctional Host Defense Peptide SPLUNC1 Is Critical for Homeostasis of the Mammalian Upper Airway

(2010) Glen McGillivary et al.   PLoS One

Chemico-genetic identification of drebrin as a regulator of calcium responses

(2009) Jason C. Mercer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia

(2009) Christie-Ann McCarl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels

(2009) Yandong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Checking your SOCCs and feet: the molecular mechanisms of Ca2+entry in skeletal muscle

(2009) Robert T. Dirksen   JOURNAL OF PHYSIOLOGY-LONDON

Rapid Ca2+flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle

(2009) Bradley S. Launikonis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

(2009) Douglas P. Millay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants of ion permeation in CRAC channels

(2009) Beth A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Myotubularin Function Results in T-Tubule Disorganization in Zebrafish and Human Myotubular Myopathy

(2009) James J. Dowling et al.   PLoS Genetics

Compromised store-operated Ca2entry in aged skeletal muscle

(2008) Xiaoli Zhao et al.   AGING CELL

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

(2008) Ilya Grigoriev et al.   CURRENT BIOLOGY

STIM1- and Orai1-dependent Store-operated Calcium Entry Regulates Human Myoblast Differentiation

(2008) Basile Darbellay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+-store-dependent and -independent reversal of Stim1 localization and function

(2008) J. T. Smyth et al.   JOURNAL OF CELL SCIENCE

Differential dependence of store-operated and excitation-coupled Ca2+entry in skeletal muscle on STIM1 and Orai1

(2008) Alla D. Lyfenko et al.   JOURNAL OF PHYSIOLOGY-LONDON

N-Acetylcysteine ameliorates skeletal muscle pathophysiology inmdxmice

(2008) Nicholas P. Whitehead et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria Are Linked to Calcium Stores in Striated Muscle by Developmentally Regulated Tethering Structures

(2008) Simona Boncompagni et al.   MOLECULAR BIOLOGY OF THE CELL

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

(2008) Jonathan Stiber et al.   NATURE CELL BIOLOGY

Skeletal Muscle Fatigue: Cellular Mechanisms

(2008) D. G. Allen et al.   PHYSIOLOGICAL REVIEWS