Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca2+ Selective Orai1 Pore

The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca2+ Channels Alter the Pharmacology of ICRAC

(2020) Sven Kappel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth

(2020) Husain Yar Khan et al.   Cancers

Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes

(2020) Matthias Sallinger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanistic insights into the Orai channel by molecular dynamics simulations

(2019) Daniel Bonhenry et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of potential CRAC channel inhibitors: Pharmacophore mapping, 3D-QSAR modelling, and molecular docking approach

(2019) S. Bhuvaneshwari et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

(2019) Anna B. Toth et al.   Science Signaling

Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain

(2019) Masahiro Enomoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding

(2019) Romana Schober et al.   Science Signaling

Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells

(2019) Sanchez-Collado et al.   Cancers

CRAC Channels as Targets for Drug Discovery and Development

(2018) Kenneth A. Stauderman   CELL CALCIUM

Current Challenges and Opportunities in Treating Glioblastoma

(2018) Andrea Shergalis et al.   PHARMACOLOGICAL REVIEWS

Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?

(2018) Natalia Prevarskaya et al.   PHYSIOLOGICAL REVIEWS

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

(2018) Priscilla S.-W. Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions

(2018) Krishna Prasad Subedi et al.   Cell Reports

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

(2018) Zhijun Liu et al.   ONCOGENE

STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription

(2018) Romana Schober et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans

(2018) Jumin Lee et al.   Journal of Chemical Theory and Computation

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

(2017) Irene Frischauf et al.   Science Signaling

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

(2017) Irene Frischauf et al.   Science Signaling

CRAC channels, calcium, and cancer in light of the driver and passenger concept

(2016) Markus Hoth   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Parametrization of halogen bonds in the CHARMM general force field: Improved treatment of ligand–protein interactions

(2016) Ignacio Soteras Gutiérrez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Store-operated CRAC channel inhibitors: opportunities and challenges

(2016) Chengsen Tian et al.   Future Medicinal Chemistry

Cell type–specific glycosylation of Orai1 modulates store-operated Ca2+entry

(2016) Kathrin Dörr et al.   Science Signaling

Cell type–specific glycosylation of Orai1 modulates store-operated Ca2+entry

(2016) Kathrin Dörr et al.   Science Signaling

Modeled microgravity suppressed invasion and migration of human glioblastoma U87 cells through downregulating store-operated calcium entry

(2015) Zi-xuan Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

(2015) Li Wen et al.   GASTROENTEROLOGY

Accounting for Electronic Polarization Effects in Aqueous Sodium Chloride via Molecular Dynamics Aided by Neutron Scattering

(2015) Miriam Kohagen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription

(2015) I. Frischauf et al.   Science Signaling

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription

(2015) I. Frischauf et al.   Science Signaling

Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer

(2014) Charlotte Dubois et al.   CANCER CELL

Store-operated Ca 2+ entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation

(2014) Meng Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Molecular pharmacology of store-operated CRAC channels

(2013) Amit Jairaman et al.   Channels

PLUMED 2: New feathers for an old bird

(2013) Gareth A. Tribello et al.   COMPUTER PHYSICS COMMUNICATIONS

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions

(2013) Gang Chen et al.   MOLECULAR IMMUNOLOGY

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

(2013) Rajender K. Motiani et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pore waters regulate ion permeation in a calcium release-activated calcium channel

(2013) H. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The action of selective CRAC channel blockers is affected by the Orai pore geometry

(2012) Isabella Derler et al.   CELL CALCIUM

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis

(2011) Huiling Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Stoichiometric requirements for trapping and gating of Ca2+release-activated Ca2+(CRAC) channels by stromal interaction molecule 1 (STIM1)

(2011) Paul J. Hoover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease

(2009) A. Di Sabatino et al.   JOURNAL OF IMMUNOLOGY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting β-cells

(2008) Natalia A. Tamarina et al.   CELL CALCIUM

CRAC inhibitors: identification and potential

(2008) Isabella Derler et al.   Expert Opinion on Drug Discovery

Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+Influx through Ca2+Release-activated Ca2+Channels

(2008) Siaw Wei Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size

(2008) Rainer Schindl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

(2008) Christine Peinelt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation