CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome

(2021) Charles Bruen et al.   PANCREAS

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

(2021) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expanding the clinical and genetic spectrum of pathogenic variants in STIM1

(2021) Chiara Ticci et al.   MUSCLE & NERVE

A first‐in‐human study to evaluate the safety, tolerability and pharmacokinetics of RP3128, an oral calcium release‐activated calcium (CRAC) channel modulator in healthy volunteers

(2020) Prajak J. Barde et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors

(2020) Marta Serafini et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors

(2019) Leila J. Noetzli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tubular aggregate myopathy and Stormorken syndrome: Mutation spectrum and genotype/phenotype correlation

(2019) Gilles Morin et al.   HUMAN MUTATION

A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy

(2019) Celia Cordero-Sanchez et al.   Disease Models & Mechanisms

Mechanisms of platelet clearance and translation to improve platelet storage

(2018) M. Edward Quach et al.   BLOOD

Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas

(2018) Antonio Omuro et al.   JOURNAL OF CLINICAL ONCOLOGY

STIM1 R304W causes muscle degeneration and impaired platelet activation in mice

(2018) Thilini H. Gamage et al.   CELL CALCIUM

STIM1 over-activation generates a multi-systemic phenotype affecting skeletal muscle, spleen, eye, skin, bones, and the immune system in mice

(2018) Roberto Silva-Rojas et al.   HUMAN MOLECULAR GENETICS

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis

(2018) Beatrice Riva et al.   JOURNAL OF MEDICINAL CHEMISTRY

ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain

(2018) M. Bulla et al.   JOURNAL OF PHYSIOLOGY-LONDON

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Identification and characterization of three novel mutations in the CASQ1 gene in four patients with tubular aggregate myopathy

(2017) Virginia Barone et al.   HUMAN MUTATION

ORAI1 Mutations with Distinct Channel Gating Defects in Tubular Aggregate Myopathy

(2017) Johann Böhm et al.   HUMAN MUTATION

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway

(2017) Saifur Rahman et al.   Scientific Reports

A novel gain-of-function mutation inORAI1causes late-onset tubular aggregate myopathy and congenital miosis

(2016) M. Garibaldi et al.   CLINICAL GENETICS

Store-operated CRAC channel inhibitors: opportunities and challenges

(2016) Chengsen Tian et al.   Future Medicinal Chemistry

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1

(2015) Thomas Markello et al.   MOLECULAR GENETICS AND METABOLISM

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

A Dominant STIM1 Mutation Causes Stormorken Syndrome

(2014) Doriana Misceo et al.   HUMAN MUTATION

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

(2014) Xuexin Zhang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Childhood onset tubular aggregate myopathy associated with de novo STIM1 mutations

(2014) Carola Hedberg et al.   JOURNAL OF NEUROLOGY

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Store-operated Ca2+Entry (SOCE) Induced by Protease-activated Receptor-1 Mediates STIM1 Protein Phosphorylation to Inhibit SOCE in Endothelial Cells through AMP-activated Protein Kinase and p38β Mitogen-activated Protein Kinase

(2013) Premanand C. Sundivakkam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy

(2013) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM and Orai in platelet function

(2011) David Varga-Szabo et al.   CELL CALCIUM

Tubular aggregates in skeletal muscle: Just a special type of protein aggregates?

(2011) Stefano Schiaffino   NEUROMUSCULAR DISORDERS

Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation

(2010) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL