The Mitochondrial Ca2+ Uniporter is a Central Regulator of Interorganellar Ca2+ Transfer and NFAT Activation

Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling

(2021) Scott M. Emrich et al.   Cell Reports

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

(2020) Ryan E. Yoast et al.   Nature Communications

BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

(2020) Corbett T. Berry et al.   Cell Reports

Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism

(2019) Kimberli J. Kamer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression

(2019) Haixin Zhao et al.   NATURE CELL BIOLOGY

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

(2019) Olha M. Koval et al.   Science Signaling

Cytoplasmic and Mitochondrial Calcium Signaling: A Two-Way Relationship

(2019) Benjamin Wacquier et al.   Cold Spring Harbor Perspectives in Biology

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

(2019) Xuexin Zhang et al.   Nature Communications

A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes

(2019) Jung Min Han et al.   PLoS Computational Biology

Mitochondrial Ca 2+ signaling

(2018) Trayambak Pathak et al.   PHARMACOLOGY & THERAPEUTICS

The whole cell Ca2+ release-activated Ca2+ current ICRAC is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na+

(2018) Krishna Samanta et al.   JOURNAL OF PHYSIOLOGY-LONDON

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

(2018) Jeffrey T. Lock et al.   Science Signaling

Store-Operated Ca 2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

(2017) Martin Vaeth et al.   IMMUNITY

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

On the dynamical structure of calcium oscillations

(2017) James Sneyd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

(2017) Xin Li et al.   Nature Communications

MICU2 Restricts Spatial Crosstalk between InsP 3 R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

(2017) Riley Payne et al.   Cell Reports

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

Orai1 pore residues control CRAC channel inactivation independently of calmodulin

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease

(2016) Michael J. Berridge   PHYSIOLOGICAL REVIEWS

Interplay Between Intracellular Ca2+ Oscillations and Ca2+-stimulated Mitochondrial Metabolism

(2016) Benjamin Wacquier et al.   Scientific Reports

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

Imaging Local Ca2+ Signals in Cultured Mammalian Cells

(2015) Jeffrey T. Lock et al.   Jove-Journal of Visualized Experiments

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

(2015) Marleen Forkink et al.   Redox Biology

An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging

(2014) Kyle L. Ellefsen et al.   CELL CALCIUM

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation

(2014) Krishna Samanta et al.   PLoS One

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Mitochondrial dynamics and their impact on T cell function

(2012) Ariel Quintana et al.   CELL CALCIUM

Generation of CD4CreERT2transgenic mice to study development of peripheral CD4-T-cells

(2012) Katayoun Aghajani et al.   GENESIS

Molecular Identity and Functional Properties of the Mitochondrial Na+/Ca2+Exchanger

(2012) Raz Palty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria and cell signalling

(2012) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation

(2011) Ariel Quintana et al.   EMBO JOURNAL

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1-Orai1-dependent store-operated Ca2+ entry

(2010) S. Naghdi et al.   JOURNAL OF CELL SCIENCE

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

(2010) I. Bogeski et al.   Science Signaling

Calcium Oscillations

(2010) G. Dupont et al.   Cold Spring Harbor Perspectives in Biology

Ca2+ transfer from the ER to mitochondria: When, how and why

(2009) Rosario Rizzuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Store-operated Ca2+ influx and subplasmalemmal mitochondria

(2009) Marek K. Korzeniowski et al.   CELL CALCIUM

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE