Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate

Store-operated CRAC channel inhibitors: opportunities and challenges

(2016) Chengsen Tian et al.   Future Medicinal Chemistry

2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1

(2016) Xiaolan Xu et al.   Scientific Reports

STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

(2015) Ayushi Vashisht et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Store-operated calcium entry: Mechanisms and modulation

(2015) Patrick G. Hogan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating

(2015) Raz Palty et al.   CELL RESEARCH

Structural and Functional Mechanisms of CRAC Channel Regulation

(2015) Ann Hye-Ryong Shim et al.   JOURNAL OF MOLECULAR BIOLOGY

Stim and Orai proteins in neuronal Ca2+ signaling and excitability

(2015) Francesco Moccia et al.   Frontiers in Cellular Neuroscience

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs

(2014) Eunan Hendron et al.   CELL CALCIUM

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

(2014) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergence of Ca2+selectivity and equilibrium Ca2+blockade in a Ca2+release-activated Ca2+channel

(2014) Megumi Yamashita et al.   JOURNAL OF GENERAL PHYSIOLOGY

State-dependent block of Orai3 TM1 and TM3 cysteine mutants: Insights into 2-APB activation

(2014) Anna Amcheslavsky et al.   JOURNAL OF GENERAL PHYSIOLOGY

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

(2014) Aparna Gudlur et al.   Nature Communications

Molecular pharmacology of store-operated CRAC channels

(2013) Amit Jairaman et al.   Channels

Emerging roles of store-operated Ca2+entry through STIM and ORAI proteins in immunity, hemostasis and cancer

(2013) Wolfgang Bergmeier et al.   Channels

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

(2013) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Roles of the C and N Termini of Orai1 Protein in Interacting with Stromal Interaction Molecule 1 (STIM1) for Ca2+Release-activated Ca2+(CRAC) Channel Activation

(2013) Hongying Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai3 TM3 point mutation G158C alters kinetics of 2-APB–induced gating by disulfide bridge formation with TM2 C101

(2013) Anna Amcheslavsky et al.   JOURNAL OF GENERAL PHYSIOLOGY

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

(2013) Beth A. McNally et al.   JOURNAL OF PHYSIOLOGY-LONDON

Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure

(2013) B. S. Rothberg et al.   Science Signaling

Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx

(2012) Bo Zeng et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

(2012) Patrick J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM/Orai signalling complexes in vascular smooth muscle

(2012) Mohamed Trebak   JOURNAL OF PHYSIOLOGY-LONDON

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane Junctions

(2011) Silvia Carrasco et al.   Annual Review of Biochemistry

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating

(2011) Judith Bergsmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

(2010) Zhengzheng Li et al.   CELL RESEARCH

Competitive Modulation of Ca2+Release-activated Ca2+Channel Gating by STIM1 and 2-Aminoethyldiphenyl Borate

(2010) Megumi Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

(2010) Annette Lis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Pharmacology of Store-operated Calcium Channels

(2010) J. W. Putney   MOLECULAR INTERVENTIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations

(2009) Salvatore Mancarella et al.   CURRENT BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STIM protein coupling in the activation of Orai channels

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

STIM, ORAI AND TRPC CHANNELS IN THE CONTROL OF CALCIUM ENTRY SIGNALS IN SMOOTH MUSCLE

(2008) Youjun Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Location and Function of STIM1 in the Activation of Ca2+Entry Signals

(2008) Thamara Hewavitharana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size

(2008) Rainer Schindl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

(2008) Christine Peinelt et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

(2007) Suhel Parvez et al.   FASEB JOURNAL