From ‘Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators

Soluble CD40 receptor is a biomarker of the burden of carotid artery atherosclerosis in subjects at high cardiovascular risk

(2022) Simone Leonetti et al.   ATHEROSCLEROSIS

Impact of smoking on cardiovascular risk and premature ageing: Findings from the STANISLAS cohort

(2022) Tripti Rastogi et al.   ATHEROSCLEROSIS

Effects of personalized diets by prediction of glycemic responses on glycemic control and metabolic health in newly diagnosed T2DM: a randomized dietary intervention pilot trial

(2022) Michal Rein et al.   BMC Medicine

Genetic, Molecular, and Cellular Determinants of Sex-Specific Cardiovascular Traits

(2022) Felix Vaura et al.   CIRCULATION RESEARCH

Targeted proteomics improves cardiovascular risk prediction in secondary prevention

(2022) Nick S. Nurmohamed et al.   EUROPEAN HEART JOURNAL

A roadmap to increase diversity in genomic studies

(2022) Segun Fatumo et al.   NATURE MEDICINE

An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs

(2022) Eric B. Fauman et al.   BMC BIOINFORMATICS

Multi-omics single-cell data integration and regulatory inference with graph-linked embedding

(2022) Zhi-Jie Cao et al.   NATURE BIOTECHNOLOGY

Sphingolipids control dermal fibroblast heterogeneity

(2022) Laura Capolupo et al.   SCIENCE

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

(2022) Gökcen Eraslan et al.   SCIENCE

A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk

(2022) Stephen A. Williams et al.   Science Translational Medicine

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

(2022) Krishna G. Aragam et al.   NATURE GENETICS

A cross-platform approach identifies genetic regulators of human metabolism and health

(2021) Luca A. Lotta et al.   NATURE GENETICS

Large-scale association analyses identify host factors influencing human gut microbiome composition

(2021) Alexander Kurilshikov et al.   NATURE GENETICS

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

(2021) Can Liu et al.   CELL

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

(2021) Robin J.G. Hartman et al.   CIRCULATION

Spectrum of splicing variants in disease genes and the ability of RNA analysis to reduce uncertainty in clinical interpretation

(2021) Rebecca Truty et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability

(2021) Marios K. Georgakis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small RNAs are modified with N-glycans and displayed on the surface of living cells

(2021) Ryan A. Flynn et al.   CELL

Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

(2021) Olivia M. de Goede et al.   CELL

Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis

(2021) Gloria C. Chi et al.   Epigenetics

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

(2021) Alice R. Carter et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

(2021) András Maifeld et al.   Nature Communications

ActiveDriverDB: Interpreting Genetic Variation in Human and Cancer Genomes Using Post-translational Modification Sites and Signaling Networks (2021 Update)

(2021) Michal Krassowski et al.   Frontiers in Cell and Developmental Biology

RNA modifications in cardiovascular diseases, the potential therapeutic targets

(2021) Yirong Wu et al.   LIFE SCIENCES

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

The cell as a bag of RNA

(2021) Stephen R. Quake   TRENDS IN GENETICS

Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study

(2021) Jiahui Si et al.   eLife

Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage

(2021) Yupeng Zhang et al.   Frontiers in Immunology

Multi-Omic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults

(2021) Daniel H. Katz et al.   Circulation-Genomic and Precision Medicine

Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease

(2021) Daniel H. Katz et al.   CIRCULATION

Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population

(2021) Kyuto Sonehara et al.   HUMAN MOLECULAR GENETICS

Combinatorial, additive and dose-dependent drug–microbiome associations

(2021) Sofia K. Forslund et al.   NATURE

A cross-population atlas of genetic associations for 220 human phenotypes

(2021) Saori Sakaue et al.   NATURE GENETICS

Large-scale integration of the plasma proteome with genetics and disease

(2021) Egil Ferkingstad et al.   NATURE GENETICS

Metabolomic Profiles Associated With Incident Ischemic Stroke

(2021) Raji Balasubramanian et al.   NEUROLOGY

Interpretation of network-based integration from multi-omics longitudinal data

(2021) Antoine Bodein et al.   NUCLEIC ACIDS RESEARCH

HMDB 5.0: the Human Metabolome Database for 2022

(2021) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Mapping the proteo-genomic convergence of human diseases

(2021) Maik Pietzner et al.   SCIENCE

Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking

(2021) Ying Mao et al.   Clinical Epigenetics

Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease

(2020) Evangelos K Oikonomou et al.   CARDIOVASCULAR RESEARCH

Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization

(2020) Verena Zuber et al.   Nature Communications

Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis

(2020) Yoko Kojima et al.   CIRCULATION

The Mediterranean diet, plasma metabolome, and cardiovascular disease risk

(2020) Jun Li et al.   EUROPEAN HEART JOURNAL

Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

(2020) Chris Wallace   PLoS Genetics

Metabolic Dysregulation of the Lysophospholipid/autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274

(2020) Sven W. Meckelmann et al.   Circulation-Genomic and Precision Medicine

Transethnic Meta-analysis of Genome-wide Association Studies Identifies Three New Loci and Characterizes Population-specific Differences for Coronary Artery Disease

(2020) Hiroshi Matsunaga et al.   Circulation-Genomic and Precision Medicine

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo

(2020) Laura Bouchareychas et al.   Cell Reports

Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases

(2020) Min Li et al.   ANGIOGENESIS

Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention

(2020) Renate M Hoogeveen et al.   EUROPEAN HEART JOURNAL

ReactomeGSA - Efficient Multi-Omics Comparative Pathway Analysis

(2020) Johannes Griss et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetics meets proteomics: perspectives for large population-based studies

(2020) Karsten Suhre et al.   NATURE REVIEWS GENETICS

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California

(2020) M. Reza Sailani et al.   Nature Communications

SIRT6 Protects Smooth Muscle Cells from Senescence and Reduces Atherosclerosis

(2020) Mandy Grootaert et al.   CIRCULATION RESEARCH

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

(2020) Joana P. Bernardes et al.   IMMUNITY

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes

(2020) Yuzhou Xue et al.   Frontiers in Genetics

DIABLO: an integrative approach for identifying key molecular drivers from multi-omic assays

(2019) Amrit Singh et al.   BIOINFORMATICS

Probing the Virtual Proteome to Identify Novel Disease Biomarkers

(2019) Jonathan D. Mosley et al.   CIRCULATION

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

(2019) Marios K. Georgakis et al.   CIRCULATION

Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes

(2019) Hyosuk Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule

(2019) Julian M Yabut et al.   ENDOCRINE REVIEWS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

A longitudinal big data approach for precision health

(2019) Sophia Miryam Schüssler-Fiorenza Rose et al.   NATURE MEDICINE

Alterations in the gut microbiome and metabolism with coronary artery disease severity

(2019) Honghong Liu et al.   Microbiome

Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome

(2019) Michael Chong et al.   CIRCULATION

Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality

(2019) Matti Marklund et al.   CIRCULATION

Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury

(2019) Christian Schulte et al.   CIRCULATION RESEARCH

Identification of Novel Causal Blood Biomarkers Linking Metabolically Favorable Adiposity With Type 2 Diabetes Risk

(2019) Marie Pigeyre et al.   DIABETES CARE

GRID-seq for comprehensive analysis of global RNA–chromatin interactions

(2019) Bing Zhou et al.   Nature Protocols

The “All of Us” Research Program

(2019)   NEW ENGLAND JOURNAL OF MEDICINE

The gut microbiome regulates host glucose homeostasis via peripheral serotonin

(2019) Alyce M. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome

(2019) Martha Guevara‐Cruz et al.   Journal of the American Heart Association

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease

(2019) Jinkuk Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

(2019) Tianxiao Huan et al.   Nature Communications

Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New Independent Predictors of Left Ventricular Dysfunction After Acute Myocardial Infarction

(2019) Maarten Vanhaverbeke et al.   Circulation-Genomic and Precision Medicine

Identification of novel diagnostic biomarkers for deep venous thrombosis

(2018) Ashfaque A. Memon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

(2018) L Clifford McDonald et al.   CLINICAL INFECTIOUS DISEASES

Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease

(2018) Jennifer Sjaarda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Blood HER2 and Uromodulin as Causal Mediators of CKD

(2018) Jennifer Sjaarda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets

(2018) Ricard Argelaguet et al.   Molecular Systems Biology

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Identification of RNA-binding protein targets with HyperTRIBE

(2018) Reazur Rahman et al.   Nature Protocols

Integrative omics for health and disease

(2018) Konrad J. Karczewski et al.   NATURE REVIEWS GENETICS

The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application

(2018) Mengmeng Lu et al.   Journal of Cardiovascular Translational Research

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

(2018) Yang Wu et al.   Nature Communications

Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

(2018) Harri Lempiäinen et al.   Scientific Reports

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Transition state characteristics during cell differentiation

(2018) Rowan D. Brackston et al.   PLoS Computational Biology

Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing

(2018) Valentina Lo Sardo et al.   CELL

Circular RNA in cardiovascular disease

(2018) M-Ashraf Altesha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

C/VDdb: A multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD)

(2018) Marco Fernandes et al.   PLoS One

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

(2018) Nora Franceschini et al.   Nature Communications

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

(2017) Sarah R. Langley et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted proteomic analysis of habitual coffee consumption

(2017) M. C. Cornelis et al.   JOURNAL OF INTERNAL MEDICINE

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins

(2017) Michal Krassowski et al.   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Effect of food intake on 92 biomarkers for cardiovascular disease

(2017) Magnus Dencker et al.   PLoS One

D-dimer and the Risk of Stroke and Coronary Heart Disease

(2017) Leslie A. McClure et al.   THROMBOSIS AND HAEMOSTASIS

Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques – Tampere Vascular Study

(2017) Miska Sulkava et al.   Scientific Reports

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure ResponseCLINICAL PERSPECTIVE

(2017) Mohamed H. Shahin et al.   Circulation-Cardiovascular Genetics

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Colocalization of GWAS and eQTL Signals Detects Target Genes

(2016) Farhad Hormozdiari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MicroRNA Regulation of Atherosclerosis

(2016) Mark W. Feinberg et al.   CIRCULATION RESEARCH

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

(2016) Hertzel C. Gerstein et al.   DIABETES CARE

Million Veteran Program: A mega-biobank to study genetic influences on health and disease

(2016) John Michael Gaziano et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Peripheral BloodMCEMP1Gene Expression as a Biomarker for Stroke Prognosis

(2016) Kripa Raman et al.   STROKE

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion

(2016) Kripa Raman et al.   PLoS One

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

(2015) Alexandre Wagschal et al.   NATURE MEDICINE

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

A framework for human microbiome research

(2012)   NATURE

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

(2011) Z. Chen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH