Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome

In Aptamers They Trust

(2019) Abhishek Joshi et al.   CIRCULATION

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

(2019) Marios K. Georgakis et al.   CIRCULATION

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

(2019) Luanluan Sun et al.   NATURE MEDICINE

Downregulation of SCARA5 may contribute to breast cancer via promoter hypermethylation

(2018) Damla Ulker et al.   GENE

Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease

(2018) Jennifer Sjaarda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

Genetically Determined FXI (Factor XI) Levels and Risk of Stroke

(2018) Dipender Gill et al.   STROKE

Iron Status and Risk of Stroke

(2018) Dipender Gill et al.   STROKE

A SNP in 5′ untranslated region of CD40 gene is associated with an increased risk of ischemic stroke in a Chinese population: a case-control study

(2017) Hua-Tuo Huang et al.   GENETICS AND MOLECULAR BIOLOGY

Mendelian randomisation in cardiovascular research: an introduction for clinicians

(2017) Derrick A Bennett et al.   HEART

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

Soluble CD163 in intracerebral hemorrhage: biomarker for perihematomal edema

(2017) Meaghan Roy-O'Reilly et al.   Annals of Clinical and Translational Neurology

Overexpression of SCARA5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the FAK signaling pathway

(2016) XINZHU WEN et al.   Molecular Medicine Reports

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

(2016) Bram. P. Prins et al.   PLOS MEDICINE

Aortic Iron Overload With Oxidative Stress and Inflammation in Human and Murine Abdominal Aortic Aneurysm

(2015) H. Sawada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elevated Plasma YKL-40, Lipids and Lipoproteins, and Ischemic Vascular Disease in the General Population

(2015) Alisa D. Kjaergaard et al.   STROKE

CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury

(2015) Hirokuni Akahori et al.   Nature Communications

Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage

(2014) Daniel Woo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

L-Ferritin Binding to Scara5: A New Iron Traffic Pathway Potentially Implicated in Retinopathy

(2014) Luísa Mendes-Jorge et al.   PLoS One

A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach

(2014) Matthew Traylor et al.   PLoS Genetics

Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial

(2013)   LANCET

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Ischemic stroke is associated with theABOlocus: The EuroCLOT study

(2012) Frances M. K. Williams et al.   ANNALS OF NEUROLOGY

Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism

(2012) Anna Helgadottir et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8

(2011) Aminah Ikner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Matrix Composition and Remodeling in Human Abdominal Aortic Aneurysms: A Proteomics Approach

(2011) Athanasios Didangelos et al.   MOLECULAR & CELLULAR PROTEOMICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

(2010) H. Zhang et al.   BLOOD

Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery

(2009) Jau Yi Li et al.   DEVELOPMENTAL CELL

Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke

(2008) Ioana Inta et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES