Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

(2019) Valentina Iotchkova et al.   NATURE GENETICS

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS

(2018) Amanda Dobbyn et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

(2018) Guiyan Ni et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci

(2018) Jarrett D. Morrow et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Bayesian framework for multiple trait colocalization from summary association statistics

(2018) Claudia Giambartolomei et al.   BIOINFORMATICS

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients

(2018) Tojo James et al.   HUMAN MOLECULAR GENETICS

Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations

(2018) Maxime Lamontagne et al.   HUMAN MOLECULAR GENETICS

Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis

(2018) Suresh Venkateswaran et al.   INFLAMMATORY BOWEL DISEASES

Expression Quantitative Trait Locus Study of Bone Mineral Density GWAS Variants in Human Osteoclasts

(2018) Benjamin H Mullin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

(2018) Alexander Gusev et al.   NATURE GENETICS

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

(2018) Kaur Alasoo et al.   NATURE GENETICS

Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

(2018) Brandon L. Pierce et al.   Nature Communications

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

(2018) Sébastien Thériault et al.   Nature Communications

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

(2018) Chihiro Endo et al.   Scientific Reports

Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs

(2018) Tetsuya Hirata et al.   Scientific Reports

Disease-specific regulation of gene expression in a comparative analysis of juvenile idiopathic arthritis and inflammatory bowel disease

(2018) Angela Mo et al.   Genome Medicine

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

(2018) Eilis Hannon et al.   Genome Medicine

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

(2018) David A Knowles et al.   eLife

An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease

(2018) Liuyang Wang et al.   Cell Host & Microbe

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Identifying the genetic risk factors for treatment response to lurasidone by genome-wide association study: A meta-analysis of samples from three independent clinical trials

(2018) Jiang Li et al.   SCHIZOPHRENIA RESEARCH

Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia

(2018) Julien Bryois et al.   Nature Communications

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

(2018) Angli Xue et al.   Nature Communications

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

(2018) Annah B. Wyss et al.   Nature Communications

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

(2018) Chen Yao et al.   Nature Communications

Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue

(2018) Oneil G. Bhalala et al.   PLoS Genetics

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

(2018) Arianne C. Richard et al.   PLoS Genetics

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

An Upper Limit on the Functional Fraction of the Human Genome

(2017) Dan Graur   Genome Biology and Evolution

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

(2016) Philip C Haycock et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Colocalization of GWAS and eQTL Signals Detects Target Genes

(2016) Farhad Hormozdiari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci

(2015) Gosia Trynka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

(2015) H. Guo et al.   HUMAN MOLECULAR GENETICS

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Research Review: Polygenic methods and their application to psychiatric traits

(2014) Naomi R. Wray et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Defining functional DNA elements in the human genome

(2014) M. Kellis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Bayesian refinement of association signals for 14 loci in 3 common diseases

(2012) Julian B Maller et al.   NATURE GENETICS

Methods to elicit beliefs for Bayesian priors: a systematic review

(2009) Sindhu R. Johnson et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Bayes factors for genome-wide association studies: comparison withP-values

(2008) Jon Wakefield   GENETIC EPIDEMIOLOGY

Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays

(2008) Nils Homer et al.   PLoS Genetics

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

(2008) Lina Chen et al.   PLOS MEDICINE