Single-cell transcriptomic and spatial landscapes of the developing human pancreas

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

(2022) Diego Balboa et al.   NATURE BIOTECHNOLOGY

Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome

(2022) Micha Sam Brickman Raredon et al.   Scientific Reports

Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans

(2021) Xin-Xin Yu et al.   CELL RESEARCH

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis

(2021) Madhav Mantri et al.   Nature Communications

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

(2021) Christopher Gribben et al.   Cell Stem Cell

Cells of the human intestinal tract mapped across space and time

(2021) Rasa Elmentaite et al.   NATURE

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

(2021) Carla A. Gonçalves et al.   Nature Communications

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

(2021) Luz Garcia-Alonso et al.   NATURE GENETICS

A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency

(2020) Chantal Lagresle-Peyrou et al.   HAEMATOLOGICA

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Trajectory-based differential expression analysis for single-cell sequencing data

(2020) Koen Van den Berge et al.   Nature Communications

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

(2020) Pallavi U. Mahaddalkar et al.   NATURE BIOTECHNOLOGY

Immune-evasive human islet-like organoids ameliorate diabetes

(2020) Eiji Yoshihara et al.   NATURE

The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Guoqing Ouyang et al.   BMC Medicine

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond

(2019) Thorsten Schaefer et al.   ONCOGENE

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

(2019) Juan R. Alvarez-Dominguez et al.   Cell Stem Cell

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

(2018) Oladapo E. Olaniru et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of the Wilms' tumor suppressor gene Wt1 in pancreatic development

(2018) Laura Ariza et al.   DEVELOPMENTAL DYNAMICS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling

(2018) Cyrille Ramond et al.   DEVELOPMENT

Lineage dynamics of murine pancreatic development at single-cell resolution

(2018) Lauren E. Byrnes et al.   Nature Communications

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

(2017) Kathryn F. Cogger et al.   Nature Communications

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Human pancreatic beta-like cells converted from fibroblasts

(2016) Saiyong Zhu et al.   Nature Communications

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton

(2016) Rui Yue et al.   eLife

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner

(2016) Daniel Hibsher et al.   Scientific Reports

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Specific Marker Expression and Cell State of Schwann Cells during Culture In Vitro

(2015) Zhangyin Liu et al.   PLoS One

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

(2014) Qingqing Zhu et al.   eLife

Knockdown of prothymosin α leads to apoptosis and developmental defects in zebrafish embryos

(2013) Anastasia Emmanouilidou et al.   Biochemistry and Cell Biology

A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis

(2013) Massimo Masiero et al.   CANCER CELL

Aldehyde dehydrogenase 1 activity in the developing human pancreas modulates retinoic acid signalling in mediating islet differentiation and survival

(2013) Jinming Li et al.   DIABETOLOGIA

Novel function of transthyretin in pancreatic alpha cells

(2012) Yu Su et al.   FEBS LETTERS

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs and their vasculature

(2012) Yuval Rinkevich et al.   NATURE CELL BIOLOGY

Ghrelin Expression in the Mouse Pancreas Defines a Unique Multipotent Progenitor Population

(2012) Luis Arnes et al.   PLoS One

Progenitor cell domains in the developing and adult pancreas

(2011) Janel L. Kopp et al.   CELL CYCLE

Vascular Smooth Muscle Progenitor Cells

(2011) Mark W. Majesky et al.   CIRCULATION RESEARCH

Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development

(2011) Limor Landsman et al.   PLOS BIOLOGY

The expression of the transcription factor FEV in adult human brain and its association with affective disorders

(2010) Claudia B. Kriegebaum et al.   JOURNAL OF NEURAL TRANSMISSION

The what, where, when and how of Wnt/β-catenin signaling in pancreas development

(2010) L. Charles Murtaugh   Organogenesis

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets

(2009) J. Olerud et al.   DIABETOLOGIA

Biphasic Ngn3 expression in the developing pancreas

(2008) Alethia Villasenor et al.   DEVELOPMENTAL DYNAMICS

Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development

(2008) J. Que et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of transcripts with enriched expression in the developing and adult pancreas

(2008) Brad G Hoffman et al.   GENOME BIOLOGY