Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway

Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling

(2022) Jifang Zheng et al.   FREE RADICAL RESEARCH

PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis

(2022) Bo Young Nam et al.   Cell Death & Disease

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model

(2022) Yanmin Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy

(2022) Ting-Ting Chang et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of the glycogen synthase kinase 3β–hypoxia‐inducible factor 1α pathway alleviates NLRP3‐mediated pyroptosis induced by high glucose in renal tubular epithelial cells

(2022) Jiayi Wan et al.   EXPERIMENTAL PHYSIOLOGY

CREBH alleviates mitochondrial oxidative stress through SIRT3 mediating deacetylation of MnSOD and suppression of Nlrp3 inflammasome in NASH

(2022) Junli Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition

(2021) Guangning Zhao et al.   Biomed Research International

VX‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation

(2021) Si Wen et al.   Journal of Diabetes Investigation

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

(2021) Nur Samsu   Biomed Research International

IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury

(2021) Ganyi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice

(2021) Ao Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis

(2021) Wei Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

(−)-Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ

(2021) Lanqiu Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation

(2021) Fanghua Guo et al.   Foods

Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy

(2020) Temitope Isaac Adelusi et al.   BIOMEDICINE & PHARMACOTHERAPY

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway

(2020) Xin An et al.   Nutrients

Biomimetic carbon monoxide nanogenerator ameliorates streptozotocin induced type 1 diabetes in mice

(2020) Cheng Zhang et al.   BIOMATERIALS

Syringaresinol Protects against Type 1 Diabetic Cardiomyopathy by Alleviating Inflammation Responses, Cardiac Fibrosis, and Oxidative Stress

(2020) Guangru Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

(2020) Qian Cheng et al.   ACTA PHARMACOLOGICA SINICA

Tetrandrine mediates renal function and redox homeostasis in a streptozotocin-induced diabetic nephropathy rat model through Nrf2/HO-1 reactivation

(2020) Luyu Su et al.   Annals of Translational Medicine

Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling

(2020) Yuqing Lin et al.   Frontiers in Immunology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease

(2019) Youliang Wang et al.   Frontiers in Endocrinology

Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy

(2019) Lei Du et al.   CELL BIOLOGY AND TOXICOLOGY

Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

(2019) Yifei Zhong et al.   Nature Communications

The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome

(2019) Gong Wang et al.   Frontiers in Immunology

Attenuation of inflammatory responses by (+)-syringaresinol via MAP-Kinase-mediated suppression of NF-κB signaling in vitro and in vivo

(2018) Vivek K. Bajpai et al.   Scientific Reports

Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation

(2018) Takami Sho et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase–2 Activation in Copper/Zinc Superoxide Dismutase–Deficient Mice

(2018) Juewon Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum�sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes

(2018) Liping Zhai et al.   Molecular Medicine Reports

Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis

(2017) Zhen Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SP600125 suppresses Keap1 expression and results in NRF2-mediated prevention of diabetic nephropathy

(2017) Huan Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Classification and Differential Diagnosis of Diabetic Nephropathy

(2017) Chenyang Qi et al.   Journal of Diabetes Research

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Comparison of human Nrf2 antibodies: A tale of two proteins

(2015) Zachary A. Kemmerer et al.   TOXICOLOGY LETTERS

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism

(2015) Siyoung Cho et al.   Oncotarget

The Predicted Molecular Weight of Nrf2: It Is What It Is Not

(2012) Alexandria Lau et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathologic Classification of Diabetic Nephropathy

(2010) T. W. C. Tervaert et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY